Anatomy Unit 4: Chps. 21-25 Flashcards
What is the circulatory system and which organ system is it composed of?
cardiovascular and lymphatic system
What is the cardiovascular system compose of and its function?
heart and blood vessels and blood to transport substances
What is the lymphatic system compose of and its function?
vascular system that circulate lymph, and part of our immune system
How much blood does an adult have?
4-6 L
What type of tissue is blood?
Connective tissue
What is whole blood and what are its components?
a component of blood, contains fluid and cellular components
– Plasma
– Formed elements
What are formed elements and what are the different types of formed elements?
cells and cell fragments
– Erythrocytes: red blood cells
– Leukocytes: white blood cells
– Platelets (aka thrombocytes): cell fragments
What are the different types of leukocytes? How are they different? Give examples of each.
– Granulocytes: WBCs with visible granules
* Neutrophils
* Eosinophil
* Basophil
– Agranulocytes: WBCs with non-staining granules
* Monocytes
* Lymphocytes
After you centrifuge blood what layers do you see?
– Hematocrit
– Buffy coat
– Plasma
What is a hematocrit? How and where is it formed? About how much is it within centrifuged blood?
Erythrocytes are denser than the other formed elements and will settle at the bottom after centrifugation consisting 37%-52% of total volume
What is the buffy coat? How and where is it formed? About how much is it within centrifuged blood?
Leukocytes and platelets settle just above the RBCs and make up <1% of blood
What is plasma? How and where is it formed? About how much is it within centrifuged blood?
makes up 47%-63% of blood settling at the top
What is within blood plasma? About how much of the following is there in blood plasma? Give a few examples of each (if applicable).
– Water: 92% of plasma
– Plasma: 7% of plasma
– Hormones
– Nutrients
– Electrolytes
– Nitrogenous wastes
– Gases
Name the different types of plasma proteins, where it is made, its relative abundance, and their functions
- Albumin: produced by liver and is the most abundant (58%) but smallest protein.
– Transport certain solutes like hormones, ions, and lipids in blood
– Buffer pH
– Maintain viscosity (thickness of blood) and osmolarity (concentration of blood)- Affects blood volume, pressure and flow
- Globulins: 37% of proteins produced by B lymphocytes and varies in weight; α (alpha), β (beta), γ (gamma)
– α (alpha), β (beta) Globulins: Transport certain solutes like hormones, ions, and lipids in blood
– γ (gamma): Immunity - Fibrinogen: 4% of proteins produced by liver and is the precursor to fibrin which forms…
– Blood clots - Regulatory proteins: <1% of proteins that are transported in blood
– Enzymes
– Hormones
What is the functions for erythrocytes?
– Transport oxygen from lungs to tissues
– Transport carbon dioxide from tissues to lungs
What is the structure of erythrocytes? What organelles do erythrocytes lack? Why is this helpful?
– Discoidal cell and shaped as biconcave disc
* No nucleus and mitochondria causing biconcavity and prevents use of the oxygen it carries
– Because there is no mitochondria, it undergoes anaerobic fermentation for energy to prevent use of oxygen for cellular respiration
What is the function of hemoglobin and about how many hemoglobin are there for each erythrocyte (not precise number)?
– Protein that carries oxygen and carbon dioxide transport
– 280 million / cell
How many globins proteins in each hemogloblin? What important component binds to oxygen in hemoglobin and which ion does this? How much CO2 is bound to hemoglobin?
– 4 Globin proteins are in each hemoglobin (two α and two β chains)
– Heme group: ferrous ion (Fe2+) that binds to oxygen
– 5% of CO2 is bound to hemoglobin
What is erythropoiesis? How does it occur and from what organ causes this?
- Erythropoiesis: erythrocyte production within (red) bone marrow
– Erythropoietin (EPO) hormone from kidney to increase production and maturation of erythrocytes
What are some erythrocyte disorders?
– Anemia
– Sickle-cell disease
What is anemia? What are some causes of anemia? What are some of the symptoms of anemia?
- Anemia: deficiency of RBC or hemoglobin
– Causes: - Decrease erythropoiesis or hemoglobin synthesis
~ Kidney failure = no erythropoietin - Hemorrhagic anemia: due to bleeding
- Hemolytic anemia: due to RBC hemolysis
– Symptoms - Hypoxia: decreased oxygen to tissues causing lethargy
and shortness of breath. Pallid skin and necrosis - Decrease blood osmolarity: causing osmosis of water from blood to tissues = edema
- Decrease blood viscosity: heart beats faster and decrease blood pressure
What is hemorrhagic anemia, hemolytic anemia, hypoxia?
- Hemorrhagic anemia: due to bleeding
- Hemolytic anemia: due to RBC hemolysis
- Hypoxia: decreased oxygen to tissues causing lethargy
What is sickle-cell disease? Who tends to have it and why?
Sickle-cell disease: recessive allele causing hemoglobin defect usually African descent (locations w/ Malaria)
What is malaria? How does having sickle-cell disease help in some situations?
Malaria: parasites that feed on hemoglobin
– But sickle-cells hemoglobin are not affected so those who are heterozygous of this are resistant to malaria
What are leukocytes and how do they get to sites of infection?
Leukocytes: white blood cells (WBCs) fights infections and diseases by going to sites of infections through diapedesis
What is diapedesis?
Diapedesis: cells squeeze between endothelial cells of blood vessels to tissues
What are the functions of each leukocytes, what do they look like, the relative abundance of each?
– Granulocytes
* Neutrophils: 50% -70% of leukocytes
~ 2-6 lobed nucleus
~ Granules are lightly stained red/purple
~ Responds to bacterial infection by secreting lysozyme
* Eosinophil: 1%-4% of leukocytes
~ Bi-lobed nucleus
~ Granules are brightly red/orange colored
~ Responds to allergies, parasitic infections, antigen-Ab complex
~ Lots in mucous membrane of respiratory, digestive, lower urinary tracts
* Basophil: 0.5%-1% of leukocytes
~ Coarse, dark violet granules hiding the nucleus (usually S or U-shaped)
~ Secretes histamine and heparin during inflammation and allergic reactions
* Secretes histamine (vasodilator) so blood can get to injured tissue (blood clotting and neutrophils can access to area)
* Secretes heparin (anticoagulant) to temporarily prevent blood clotting so neutrophils and eosinophils can access site
– Agranulocytes
* Monocytes: 2%-8%
~ Largest leukocytes
~ Large nucleus and usually kidney or horseshoe-shaped
~ Responds to viral infections and inflammation by leaving bloodstream and becoming macrophages to phagocytize debris, bacteria, and dead cells
* Lymphocytes: 20%-40 %
~ Smallest leukocytes around the same size as RBCs when non-activated
~ Nucleus is round, oval, or slightly dimpled and fills almost entire cell with halo of cytoplasm
~ Depending on subclass has different immune functions such as attacking foreign, abnormal, or infected cells, produce antibodies.
* T-cell: mature in thymus and attack foreign cells directly
* B-cell: mature in bone marrow which becomes plasma cells and produce antibodies to be marked for macrophages to destroy them
What are the differences between T cell vs B cells?
- T-cell: mature in thymus and attack foreign cells directly
- B-cell: mature in bone marrow which becomes plasma cells and produce antibodies to be marked for macrophages to destroy them
How are leukocytes made?
red bone marrow containing granules
How are platelets produced?
fragments of megakaryocytes (bone marrow cells)
Where are blood cells produced?
Red bone marrow
– Hemopoiesis: production of all blood cells
Where is red bone marrow located in children vs adults?
- Children: red bone marrow located in spongy bone and medullary cavity of bones
- Adults: red bone marrow located at axial skeleton and proximal epiphyses of humerus and femur
What do the locations that used to produce blood become?
Red bone marrow turns into fat (yellow bone marrow)
What are the two circulations of the cardiovascular system and which side of the heart is for which circulation?
- Cardiovascular System: heart, blood vessels, and blood
– Pulmonary circulation: carries blood from right side of the heart to lungs and back to oxygenate blood
– Systemic circulation: carries blood from left side of the heart to organs and back
What are the layers around the heart and its function and tissue it is made of?
– Fibrous pericardium: dense irregular CT that surrounds the heart and attaches to diaphragm and great vessels
– Serous Pericardium: 2 layers of serous membrane that surround the heart (made of simple squamous epithelium and connective tissue)
* Parietal pericardium: serous membrane that lines the fibrous pericardium
➢ Pericardial cavity: space between the two layers
* Visceral pericardium/epicardium: serous membrane that is on the outer surface of the heart
What is the pericardial cavity? And what type of fluid is in this space and its function?
space between the parietal pericardium and the visceral pericardium
– pericardial fluid: serous fluid from serous pericardium to lubricate between the two membranes to reduce friction
What are the great vessels (4), where do they come from/go to?
- Great vessels: large blood vessels that enter/exit heart
– Inferior and superior venae cavae: entering the R atrium
– Pulmonary trunk: from R ventricle through pulmonary semilunar valve
– Pulmonary veins: entering the L atrium
– Aorta: from the L ventricle through aortic semilunar valve
Where is the heart located at?
Heart is within the thoracic cavity in the mediastinum (area between the lungs)
What is the superior part of the heart known as? How about the inferior part of the heart?
- Base: superior part of the heart where
great vessels are attached - Apex: inferior end of the heart
What is the size of the heart?
about your fist size
What are the layers of the heart wall and their tissues?
– Epicardium/visceral pericardium: serous membrane on the outermost layer of heart
– Myocardium: thickest layer made of cardiac muscles
– Endocardium: inner layer of the heart chambers, made of simple squamous epithelium over areolar connective tissue; continuous with the endothelium of blood vessels
What are the four chambers of the heart and their functions? What structures do you have within each chamber and their functions?
– R/L Atria: superior chambers that receives blood from body/lungs to the heart
* R/L Auricle: anterior earlike extension of atria that increase volume of the atria
* Interatrial septum: separates the R vs L atria
– R/L Ventricle: inferior chambers that
pumps blood away from the heart
* Trabeculae carnae: internal ridges of muscles within the ventricles
* Interventricular septum: separates the R vs L ventricles
What are the four coronary chambers called and their functions?
– Right atrium: receives blood from the body
– Right ventricle: pumps blood to the lungs
– Left atrium: receives blood from the lungs
– Left ventricle: pumps blood to the body to the systemic circuit
What structure do you find in the right atrium?
Fossa ovalis: depression in right atrium which was the former location of fetal foramen ovale when blood goes from right atrium to left atrium in fetus
How are the right vs left ventricles different and why?
– Right ventricle pumps blood to the lungs
– Left ventricle pumps blood to the body’s systemic circuit
* Thicker myocardium than the right ventricle to have enough strength to pump to the entire body
What are the function of the coronary valves?
to keep blood flowing one way
What are cusps?
flaps that make up the valves
What are the coronary valves called and where are they found?
– Atrioventricular valves: between the atria and ventricles
– Semilunar valves: between the ventricles and great vessels
What structures do you find associated with the atrioventricular valves and their functions?
– Chordae tendineae: collagen fibers that connects cusps to papillary muscles
– Papillary muscles: contract when ventricles contract to prevent valves from flipping inside out and ensuring one- way flow of blood
What are the 4 heart valves called and where are they located at?
- Right atrioventicular (AV)/tricuspid valve: 3 cusps between the right atrium and right ventricle
- Pulmonary semilunar valve: 3 cusps that occurs between the right ventricle and pulmonary trunk
- Left atrioventicular (AV)/bicuspid/mitral valve: 2 cusps between the left atrium and left ventricle
- Aortic semilunar valve: 3 cusps occurs between the left ventricle and aorta
How many cusps are there in each heart valve?
- Right atrioventicular (AV)/tricuspid valve: 3 cusps
- Pulmonary semilunar valve: 3 cusps
- Left atrioventicular (AV)/bicuspid/mitral valve: 2 cusps
- Aortic semilunar valve: 3 cusps
What is the term to listen to the sounds of the body?
Auscultation: listening to sounds of the body
What is lub-dub? Which valves closes for which sound?
– First heart sound (S1): “lub”, turbulence in bloodstream as AV valves closes and tensing of chordae tendineae
– Second heart sound (S2): “dub”, turbulence in bloodstream as semilunar valves closes
What is a murmur?
abnormal heart sound by abnormal blood flow of the heart
What is systole vs diastole? What does it typically refer to?
– Systole: contraction
– Diastole: relaxation
~ Typically refers to the ventricles
Name all the structures as blood flows to and out of the heart.
- Systemic circuit
– Blood arrives from the body to the heart by the
– Superior vena cava: blood from the upper body and…
– Inferior vena cava: blood from the lower body which then goes to…
– Right atrium and through…
➢ Right atrioventricular valve to… - Pulmonary circuit
– Right ventricle where blood is pumped through… ➢ Pulmonary semilunar valve to…
– Pulmonary trunk which bifurcates into…
– R/L Pulmonary arteries to become…
– Pulmonary arterioles to become…
– Pulmonary capillaries to get oxygenated and release carbon dioxide and then goes to the
– Pulmonary venules which become…
– R/L Pulmonary veins to…
– Left atrium and through…
➢ Left atrioventricular valve to… - Systemic circuit
– Left ventricle where blood is pumped through… ➢ Aortic semilunar valve to…
– Ascending aorta to the…
– Aortic arch to the rest of the body
Which parts is the systemic circuit which is the pulmonary circuit?
- Systemic circuit
– Blood arrives from the body to the heart by the
– Superior vena cava: blood from the upper body and…
– Inferior vena cava: blood from the lower body which then goes to…
– Right atrium and through…
➢ Right atrioventricular valve to… - Pulmonary circuit
– Right ventricle where blood is pumped through… ➢ Pulmonary semilunar valve to…
– Pulmonary trunk which bifurcates into…
– R/L Pulmonary arteries to become…
– Pulmonary arterioles to become…
– Pulmonary capillaries to get oxygenated and release carbon dioxide and then goes to the
– Pulmonary venules which become…
– R/L Pulmonary veins to…
– Left atrium and through…
➢ Left atrioventricular valve to…
Which parts have oxygenated blood and what parts have “deoxygenated” blood?
- Deoxygenated blood:
– R/L pulmonary arteries, pulmonary arterioles
➢ Pulmonary capillaries: where gas exchange occurs to get oxygenated and release CO2 and then goes to… - Oxygenated blood:
– pulmonary venules, pulmonary veins
What is coronary circulation? What are cardiocytes?
- Coronary Circulation: allows oxygen/nutrients in blood to be delivered to the cardiocytes and delivers carbon dioxide/wastes from cardiocytes to blood
- Cardiocytes: cardiac muscles
What is myocardial infarction (MI)?
heart attack when interruption of blood supply to the myocardium which can cause necrosis (tissue death)
What are anastomoses and why is it important?
alternate routes to provide blood to tissue in case one is blocked
What are the vessels for coronary circulation and their functions?
Ascending aorta’s base leads to…
– Left coronary artery (LCA): which travels along the coronary sulcus and branches off to the…
* Anterior interventicular artery /left anterior descending (LAD) branch: which travels along the anterior interventricular sulcus which then joins to the posterior interventricular artery; supplies blood to ventricles and anterior 2/3 of interventricular septum
* Circumflex artery: which travels along the coronary sulcus; supplies blood to the left atrium and posterior wall of left ventricle and becomes the…
– Right coronary artery (RCA): which travels along the coronary sulcus; supplying blood to right atrium and sinoatrial (SA) node and atrioventricular (AV) node becomes…
* Right marginal artery: which supplies the lateral right atrium and ventricle
* Posterior interverticular artery/posterior descending artery: travels along the posterior interventricular sulcus and supplies posterior ventricles and interventricular septum and joins the anterior interventricular artery
Coronary arteries will become what type of blood vessels and that will become what type of blood vessels?
Coronary arterioles –> capillaries
What will those coronary capillaries become, which will then become which cardiac veins and their functions?
Coronary capillaries to coronary venules to…
* Great cardiac vein: travels along anterior interventricular sulcus; collects blood from anterior heart and empties into the coronary sinus
* Posterior interventricular vein/middle cardiac vein: travels along the posterior interventricular sulcus; collects blood from posterior heart and drains into coronary sinus
* Small cardiac vein: travels along the coronary sulcus between the right atrium and right ventricle and empties into the coronary sinus
* Coronary sinus: located on the posterior heart in the coronary sulcus and collects blood from all these veins and empties into…
* Right atrium
What are some (6) properties of cardiocytes and their functions?
– Auto-rhythmic: contracts regularly ~75 beats per minute (bpm) (without nervous system innervating it)
– Striated
– Involuntary
– Single or two, centrally located nucleus
– Branched: to connect to multiple cardiocytes so contracts as one unit
– Intercalated discs has these properties:
* Mechanical junctions
* Gap junctions
What is the cardiac conduction system?
internal pacemaker and nerve-like conduction pathway within the myocardium to generate rhythmic beating of the heart
What are the different structures that make up the cardiac conduction system?
– Sinoatrial (SA) node/pacemaker: modified cardiocytes in right atrium under epidcardium near superior vena cava; initiates heartbeat and heart rate
– Internodal pathway: Action potential of cardiocytes spreads across atria and go to…
– Atrioventricular (AV) node: at interatrial septum near right AV valve and surrounded with fibrous skeleton, electric signals then travels to…
– Atrioventicular (AV) bundle/ Bundle of His: found within the interventricular septum and branches into the…
– R/L bundle branches: travels within the interventricular septum and become…
– Purkinje fibers : travels from the apex and up to the ventricles stimulating cardiocytes to contract
What are the nerve supply to the heart?
- Sympathetic nervous system: stimulate the heart rate (up to 230 bpm)
– Preganglionic nerve: From spinal cord to sympathetic chain ganglion
– Postganglionic nerve: from sympathetic chain ganglion through cardiac plexus to the heart
– Terminating at - SA and AV node: increase heart rate and stroke volume
- Aorta, pulmonary trunk and coronary arteries: vasodilation
- Parasympathetic nervous system: decreases heart rate (to 20 bpm or stop for a couple seconds)
– Preganglionic nerve: Vagus nerve (CN X) through cardiac plexus and synapse at…
– Postganglionic nerve: at the epicardial surface and heart wall
– Terminating at - SA node: mostly from right CN X
- AV node: mostly from left CN X
- Causes decrease heart rate only
What are some of the sensory nerves from the heart for?
Sensory nerves from heart to CNS for cardiovascular reflexes and pain signals of the heart
Where is the cardiac center located at?
Cardiac center located at the medulla oblongata
What are some of the fetal structures and what do they become as adults? What are their functions?
– Foramen ovale: opening between the atria, since the lungs are not functioning, blood is by passed from the lungs to L atrium
* When we are born, lungs causes the closing of foramen ovale forming fossa ovalis
– Ductus arteriosus: blood that enters right ventricle will go through pulmonary trunk and then to the aorta through this structure bypassing lungs since it is not functioning
* When we are born, ductus arteriosus closes becoming the fibrous ligamentum arteriosum
What is the differences between arteries, veins and capillaries? What are their functions?
- Arteries: efferent vessels of the cardiovascular system (carrying blood AWAY from the heart)
- Veins: afferent vessels of the cardiovascular system (carrying blood TOWARD the heart)
- Capillaries: microscopic, thin-walled vessels that connects arteries and veins for exchanging material
What are the blood vessel layers?
– Tunica interna
– Tunica media
– Tunica externa
What are the tissues that make up each layer of the blood vessels and their functions?
– Tunica interna:
* Endothelium: Simple squamous epithelium
* Basement membrane
* Areolar connective tissue
* Elastic fibers (may occur within arteries)
– Tunica media:
* Smooth muscle: to control diameter in vessels; larger in arteries than veins
* Elastic fibers (may occur within arteries)
– Tunica externa:
* Areolar connective tissue
* Elastic and collagen fibers (more in arteries than veins)
What is endothelium?
Simple squamous epithelium
Which blood vessels tend to have elastic fibers?
Mostly arteries
What is vasoconstriction vs vasodilation? How does that affect blood pressure?
– Vasoconstriction: narrowing of blood vessel lumen diameter; causing high BP
– Vasodilation: opening of blood vessel lumen diameter; reducing high BP
What are the different types of blood vessels in the body?
– Arteries
* Elastic arteries / Conducting arteries
* Muscular arteries / Distributing arteries
* Arterioles
– Capillaries
* Continuous capillaries
* Fenestrated capillaries
* Sinusoids
– Veins
* Postcapillary venules
* Medium veins
* Venous sinuses
* Large Veins
What are elastic arteries? Name some examples. What are the function of elastic arteries?
- Elastic-/conducting/large arteries: largest arteries
– Ie: aorta, common carotid, subclavian, common iliac arteries, and pulmonary trunk and arteries
– Functions: - Elastic arteries expand during ventricular systole (contraction) preventing damaging smaller blood vessels
- Recoils during diastole (relaxation) due to the elastic fibers propelling the blood forwards and preventing drop in blood pressure between systoles
What are muscular arteries? Name some examples. What are the function of muscular arteries?
- Muscular/distributing/medium arteries: distribute blood to organs
– Ie: most of the named bv’s: brachial, femoral, renal, splenic, anterior tibial, coronary, inferior mesenteric arteries
– Thicker tunica media because of smooth muscles allowing for vasoconstriction/vasodilation