Anatomy-Endterm Flashcards
Function of cartilage
- Bear mechanical stress
- Shock-absorber
- Essential for growth and development of bone
Characteristics of cartilage
- Has periosteum that surrounds on all sides of the cartilage
- Made of chondrocytes that are within lacunae
- Ground substance has proteoglycan and hyaluronic acid which absorbs stare so when you touch it, it comes back like a spring
- Avascular and no nerve supply
Cartilage development
- Mesenchymal cells differentiate into chondroblasts
- Chondroblasts mitotically divide and form isogenic groups
- Chondroblasts secrete the ECM
- ECM captures the chondroblasts and divides them into separate cells called chomdrocytes
Chondrocytes
Can’t divide and mature cartilage cells
Interstitial growth
Growth that results from the chondroblasts. It goes along the length
Appositional growth
Growth that happens in the perichondrium and grows along the width
Hyaline cartilage
- Contains collagen type II fibrils and ground substance
- Has perichondrium all around it
- Fresh hyaline cartilage is whitish-bluish
- In the embryo:forms the temporary skeleton
- Chondrocytes that are active show basophilia along the lacunae
- Inactive chondrocytes have white spaces which is for glycogen storage and fat droplets
- Matrix calcifies
- Supports structures and is flexible
- Found in articulations cartilage, nasal septum, epiphyseal plate, respiratory passages
Articular cartilage
Does not have perichondrium . So get nutrients from diffusion of the synovial fluid
Epiphyseal plate
Doesn’t have perichondrium
Perichondrium
Dense irregular connective tissue that has vascularity and blood supply and provides it to the avascular cartilage
Elastic cartilage
- Has elastin and collagen type II fibers
- Matrix doesn’t calcify
- Has perichondrium around it
- Provides support and maintains shape of structure
- Ex: outer part of ear, external auditory canal, epiglottis of larynx
Fibrocartilage
- Mostly has collagen type I fibrils but also has collagen type II fibrils
- Chondrocytes are arranged by themselves or in isogenous groups in rows
- In between the rows, there are collagen type I fibers
- No perichondrium
- Matric calcifies
- Is acidophilic due to collagen type I
- Function is support and rigidity
- Ex: meniscus, intervertebral disc, pubic symphysis
Function of bone
- Protection
- Movement
- Creating blood vessels in the bone marrow
- Storing Ca and P
Compact bone
Composed of longitudinal circular structures called osteons or Haversians
Help resist stress
Lamella
Concentric rings around the central part. Used to find the age of the bone
Between lamellae are lacunae consisting of osteocytes
Cannaliculi
Projections of the lacunae that connect with one another to provide nutrients and blood supply.
Filled with extracellular fluid
Spongy Bone
Does not have osteons. Instead lamellae are arranged in a sheet with spaces in them called trabiculae (help make the bone lighter)
Hematopoeisis occurs in spongy tissue. Each trabiculae has lamina consisting of osteocytes
Trabiculae
Lines across areas of stress. Blood fills the spaces of the trabiculae and this nourishes osteocytes
Osteopenia or progenitor cells
Mesenchymal cells that will form osteoblasts
Osteoblasts
Mitotically active cells that divide and give rise to osteocytes.
Work in teams to make new bone called osteoid
Help deposit calcium and minerals into the bone
Found at the edge of bone
Osteoclasts
Derived from monocytes
Break down bone and bring calcium from the bone to the bloodstream. So blood Ca levels are regulated by osteoclasts
Found at the edge of bone
Osteocytes
Mature, non-dividing cells trapped in lacunae
Ossification
Happens in embryological development from week 6-8
2 types:
- Intramembranous
- Endochondral
Intramembranous ossification
Mesenchymal tissue is replaced by ossified tissue. Osteoblasts begin to appear and form spongy bone. Spongy bone is remodeled to form compact bone