Anatomy-Endterm Flashcards
Function of cartilage
- Bear mechanical stress
- Shock-absorber
- Essential for growth and development of bone
Characteristics of cartilage
- Has periosteum that surrounds on all sides of the cartilage
- Made of chondrocytes that are within lacunae
- Ground substance has proteoglycan and hyaluronic acid which absorbs stare so when you touch it, it comes back like a spring
- Avascular and no nerve supply
Cartilage development
- Mesenchymal cells differentiate into chondroblasts
- Chondroblasts mitotically divide and form isogenic groups
- Chondroblasts secrete the ECM
- ECM captures the chondroblasts and divides them into separate cells called chomdrocytes
Chondrocytes
Can’t divide and mature cartilage cells
Interstitial growth
Growth that results from the chondroblasts. It goes along the length
Appositional growth
Growth that happens in the perichondrium and grows along the width
Hyaline cartilage
- Contains collagen type II fibrils and ground substance
- Has perichondrium all around it
- Fresh hyaline cartilage is whitish-bluish
- In the embryo:forms the temporary skeleton
- Chondrocytes that are active show basophilia along the lacunae
- Inactive chondrocytes have white spaces which is for glycogen storage and fat droplets
- Matrix calcifies
- Supports structures and is flexible
- Found in articulations cartilage, nasal septum, epiphyseal plate, respiratory passages
Articular cartilage
Does not have perichondrium . So get nutrients from diffusion of the synovial fluid
Epiphyseal plate
Doesn’t have perichondrium
Perichondrium
Dense irregular connective tissue that has vascularity and blood supply and provides it to the avascular cartilage
Elastic cartilage
- Has elastin and collagen type II fibers
- Matrix doesn’t calcify
- Has perichondrium around it
- Provides support and maintains shape of structure
- Ex: outer part of ear, external auditory canal, epiglottis of larynx
Fibrocartilage
- Mostly has collagen type I fibrils but also has collagen type II fibrils
- Chondrocytes are arranged by themselves or in isogenous groups in rows
- In between the rows, there are collagen type I fibers
- No perichondrium
- Matric calcifies
- Is acidophilic due to collagen type I
- Function is support and rigidity
- Ex: meniscus, intervertebral disc, pubic symphysis
Function of bone
- Protection
- Movement
- Creating blood vessels in the bone marrow
- Storing Ca and P
Compact bone
Composed of longitudinal circular structures called osteons or Haversians
Help resist stress
Lamella
Concentric rings around the central part. Used to find the age of the bone
Between lamellae are lacunae consisting of osteocytes
Cannaliculi
Projections of the lacunae that connect with one another to provide nutrients and blood supply.
Filled with extracellular fluid
Spongy Bone
Does not have osteons. Instead lamellae are arranged in a sheet with spaces in them called trabiculae (help make the bone lighter)
Hematopoeisis occurs in spongy tissue. Each trabiculae has lamina consisting of osteocytes
Trabiculae
Lines across areas of stress. Blood fills the spaces of the trabiculae and this nourishes osteocytes
Osteopenia or progenitor cells
Mesenchymal cells that will form osteoblasts
Osteoblasts
Mitotically active cells that divide and give rise to osteocytes.
Work in teams to make new bone called osteoid
Help deposit calcium and minerals into the bone
Found at the edge of bone
Osteoclasts
Derived from monocytes
Break down bone and bring calcium from the bone to the bloodstream. So blood Ca levels are regulated by osteoclasts
Found at the edge of bone
Osteocytes
Mature, non-dividing cells trapped in lacunae
Ossification
Happens in embryological development from week 6-8
2 types:
- Intramembranous
- Endochondral
Intramembranous ossification
Mesenchymal tissue is replaced by ossified tissue. Osteoblasts begin to appear and form spongy bone. Spongy bone is remodeled to form compact bone
Endochondral ossification
Cartilage provides the framework of the bone. Osteoclasts will begin to digest the cartilage in the diaphysis and osteoblasts will lay down new bone. Blood vessels will begin to emerge and the medullary cavity will hollow out. Blood vessels and osteoblasts will then go to the epiphysis
Cartilage will remain only at the articular surface and epiphyseal plate
Primary center of ossification
Diaphysis
Secondary center of ossification
Epiphysis
Growth of bone
Osteoclasts will eat up a portion of the epiphyseal plate and then osteoblasts will put in new bone
When a person becomes an adult, epiphyseal plate will become epiphyseal line
Repair of bone
- Form fracture hemmatoma: clots blood
- Fibrocartilage callus formation: fibroblasts invade the site and form collagen fibers to bring the broken pieces of bone together
- Bony callus formation: osteoblasts will form bone
- Bone remodeling: spongy bone is converted to compact bone
Bone takes so long to heal…
Since calcium and phosphorus are deposited gradually over a period of months
Calcium and phosphorus
Helps harden bone
Types of muscle tissue
- Skeletal: allows movement and attached to bone
- Cardiac
- Smooth: found in the walls of hollow contracting organs (blood vessels, urinary bladder, digestive tract)
Function of muscle
- Protection
- Movement
- Generating heat through involuntary contraction of skeletal muscles
- Posture
Properties of muscle tissue
- Excitability
- Condunctivity
- Elasticity
- Contractability
- Extensibility
Histology of skeletal muscle
Is striated, long, multinucleated, voluntary
Has 3 CT coverings: epimysium, perimysium, and endomysium
Cells don’t divide
Epimysium
Dense irregular connective tissue that covers fasicles
Perimysium
Collagen and elastin fibrous connective tissue in between fasicles
Endomysium
Reticular connective tissue in between muscles cells/fibers
Fascia
Covering outside of the epimysium
Tendon
Cord-like extension of outer fascia that connects a muscle to bone
Muscle belly
Portion of muscle in between tendons
Musculotendinous junction
Part where the epimysium comes together to form a tendon
Aponeurosis
Broad sheet-like extension of pearly-white fibrous tissue of deep outer fascia
Raphe
Seam like aponeurosis
Skeletal muscle cells
Multinucleated and are striated, voluntary, and don’t divide
Don’t have cellular junction
Satellite cells
Stem cells at the edge of skeletal muscle cells that can differentiate into cells when there is an injury
Sarcoplasm
Cytoplasm of muscle cells
Sarcoplasmic reticulum
ER of muscle cells
Sarcolemma
Cell membrane of muscle cells
Forming skeletal muscle cells
Hundreds of myoblasts come together and fuse
Growth of skeletal muscle cells
Can’t divide so growth is through enlargement of the cell
T-tubules
Helps conduct impulses. Leads to Ca release when an AP has been produced. Go into the sarcoplasmic reticulum
Role of calcium
- Stored=relaxed
- Released=contraction
Myofibrils
Have a lot in muscle cells. They have thick and thin microfilaments which are responsible for contraction
Striation of muscle cells
Have two bands
- Light band (I band)
- Dark band (A band)
I band
Is the light band. Has a freak line in the middle called the Z disk
A band
Is the dark band. Has a light region in the center called the H zone and a dark line called the M line
Can only see the H zone is relaxed cells, not contracting one
Thick myofilament
Made up of myosin.
Each myosin looks like 2 golf heads intertwined together
Extend towards the thin filaments and bind to it
Held in place by the M line
Thin myofilament
Made of actin, tropomyosin, and troponin
Held in place by the Z disk
Neuromuscular junction
The junction between the skeletal muscle cell and the nerve fiber
Cardiac muscle cells
Striated, involuntary, highly branched, single central nucleus
Cells are connected by intercalated discs
Has only endomysium
Has T tubules+sarcoplasmic reticulum
No neuromuscular junction+mitosis
Intercalated discs
Contains gap junctions and desmosomes which allows the cells to work in syncytium
Smooth muscle cells
Involuntary, small, tapered, central nucleus
Can divide and regenerate
Form 2 sheets: longitudinal+circular
Has only endomysium
No T-tubules and sarcoplasmic reticulum
Has gap junctions and no neuromuscular junction
Longitudinal sheets
Wide and short lumen
Circular
Long and narrow lumen
Regeneration of smooth muscle
Can grow (hypertrophy) and some can divide (hyperplasia)
New fibers can form from stem cells in the blood vessel walls
4 classifications of skeletal muscles based on fasicle arrangement
- Parallel
- Convergent
- Pennate
- Circular
Parallel classification
Most common classification. These muscles are not that strong
Strap-like broad attachment
So basically aponeurosis.
Ex: satorius and sternohyoid
Strap-like with tendinous intersections
Rectus abdominus
Strap like with muscle belly
Has a tendon in between muscle
Ex: biceps brachii
Convergent muscles
All meet up at one point. They are triangular or fan-shaped
Ex: pectoral is major
Pennate
They attach to the intersection at one point (unipennate), two points (bipennate), or many points (multipennate)
Have the highest concentration of fibers and are the most powerful muscles
Unipennate
Attaches at one point
Ex: exterior digitorum longus
Bipennate
Attaches at two ends
Ex: Rectus femoris
Multipennate
Attaches to bone at many sides
Ex: deltoid
Circular muscles
Arranged in concentric rings around an external body opening
Ex: orbicularis oris muscle
Functional muscle groups
Can be divided into:
- Agonist
- Antagonist
- Synergists
- Fixators
Agonists (prime movers)
Muscles that provide the major force for flexion
Ex: biceps brachii in the flexion of the arm
Antagonists
Go against the force of the agonist
Ex: triceps brachii in elbow flexion
Synergists
Muscles that stabilizes the agonists and antagonists and makes sure it doesn’t rotate
Ex: brachialis in elbow flexion
Fixators
Muscles that fix against bone so that the bone doesn’t move as well
Ex: serratous anterior muscle attaches the scapula to the thorax during arm movement
Rectus
Fasicles are arranged vertically
Ex: Rectus abdominus
Transversus
Fasicles are arranged horizontally
Ex: transverse abdominus
Oblique
Fasicles are arranged diagonally
Ex: External oblique
Brachium
Arm
Frontalis
Near the frontal bone
Occipitalis
Located near the occipital bone
Externus (superficialis)
Visible at the body’s surface
Internal (profundus)
In deep muscles
Externalis
Muscles outside organs
Internalis
Muscles inside an organ
Minumus
Smallest
Ex: gluteus minimus
Medius
Middle
Ex: gluteus minimus
Maximus
Largest
Ex: gluteus maximus
Longus
Longest
Ex: fibularis longus
Brevis
Shorter than longus
Ex: fibularis brevis
Tertius
Shortest
Ex: fibularis tertius