Anatomy and Surgery 1 Flashcards
Lining of epidermis
Stratified squamous epithelium
Immune cells in the epidermis
Langerhan’s cells
Nerve cells in dermis
Meissner’s (light touch), Pacinian (pressure)
Major chemoattractant for fibroblasts during the proliferation phase of wound healing
PDGF
Threshold of pressure injury
At least 1 hour of 60mmHg pressure
Apocrine gland blockage, infection and abscess formation
Hidradenitis suppurativa
Present as nodules and spread to form draining tracts. (+) sulfur granules on histology
Actinomycosis - follows tooth extraction, osontogenic infection, facial trauma
Rapidly enlarging, necrotic ulcer with violet border and surrounding erythematous halo
Pyoderma gangrenosum - linked to ulcerative colitis, IBD
Immune mediated, separation of skin at dermo-epidermal junction and >30% TBSA involvement
Toxic Epidermal Necrolysis
Most common site of dermoid cyst
Eyebrow
Skin lesions that yellow, non-tender, pruritic with a velvety greasy texture. Found in chest, back and abdomen,
Seborrheic keratoses - unrelated to sun exposure
Sudden multiple eruptions of seborrheic keratoses associated with ovarian or gastric Ca
Lesser Trelat Sign
Tender, warty, brown or black lesions on sun exposed areas
Solar (actinic) keratoses - premalignant (SCC)
Treatment for congenital nevi
Excision, since it is premalignant
Most common benign head and neck tumor in adults
Hemangioma - initial rapid proliferation followed by slow involution
Consumptive coagulopathy due to a hemangioma
Kasabach Merritt Syndrome
Benign neoplasm usually affecting hands
Glomus tumor - blue, subungual discolortion associated with tenderness and cold sensitivity
Most common soft tissue tumor
Lipoma
Neural tumor that invades striated skeletal muscles
Granular Cell Tumor
Histology: Neurilemoma
Schwann cells packed in palisading rows
Most common type of skin cancer?
Basal Cell Carcinoma - waxy, cream colored with rolled, pearly borders surrounding a central ulcer
Histopath: Squamous cell carcinoma
Keratin pearls
SCC in situ
Bowen’s Disease
SCC in penis
Erythroplasia of Queyrat
SCC arising from burn areas
Marjolin’s Ulcer - has an earlier metastasis
Most common spread of malignant melanoma
Superficial spread (70%) - anywhere except hands and feet
Malignant melanoma with the best prognosis
Lentigo maligna - face, neck, hands of elderly
Least common malignant melanoma, most common on great toe or thumb
Acral lentiginous - (+) Hutchinson’s sign or pigment in paronychial area
Provides structural support to the breast
Cooper’s suspensory ligaments - anchors the dermis to the pectoralis fascia
Provides a route for Breast Ca metastases to bone
Batson’s Vertebral Plexus
Measurement of gynecomastia
At least 2cm in diameter
Thrombophlebitis that involves the superficial veins of the anterior chest wall and breast
Mondor’s Disease - acute pain on lateral side, tender and firm cord following vein distribution
Veins involved in Mondor’s Disease
Lateral thoracic vein, thoracoepigastric vein, superficial epigastric vein
Epidemic puerperal mastitis is due to?
MRSA
Tx for non epidemic (sporadic) mastitis
Empty breast using suction pumps, I&D cannot be done
Mimics Breast Ca on PE, mammogram and gross pathologic examination
Radial Scars and Complex Sclerosing Lesions - need to do biopsy
Large, pale, vacuolated cells in the rete pegs of epithelium of the breast
Paget Cells - chronic eczematous eruption of the nipple
Differentiate Paget’s Disease from Melanoma
(+) CEA - Paget’s Disease, (+) S 100 - Melanoma
Most common invasive Breast Ca
Invasive ductal Ca - (+) axillary LN, central stellate configuration with chalky white or yellow streaks
Invasive Breast Ca associated with BRCA 1 cancers
Medullary Ca - soft, hemorrhagic and bulky
Invasive Breast Ca with the best prognosis
Tubular Ca
Histopathology: Indian file configuration of cells, Signet ring cell Ca
Invasive Lobular Carcinoma
Biopsy method for breast lesions
Core needle biopsy
Gold standard in Breast Ca management
MRM - removal of all breast tissue and pectoralis fascia, ALND (I and II)
Moveable, midline neck mass
Thyroglossal Duct Cyst - Tx is Sistrunk Operation
Most common Branchial Cleft Anomaly
2nd - lateral neck at SCM and tonsillar fossa openings
Mucous retention cyst involving the sublingual gland
Ranula - found in the floor of the mouth, treat with Marsupialization
Granulomatous lesion in the oral cavity that is an exaggerated inflammatory response
Epulis - Tx is excision if symptomatic, same appearance as a malignant lesion in the gingiva
Expansive endosteal lesion of the mandible, of bony origin
Central Giant Cell Reparative Granuloma - Tx is curettage
Rare benign tumor of tongue (mid 1/3), derived from Schwann cells
Granular Cell Myoblastoma or Abrikossof tumor - Tx is wedge excision to r/o SCC of tongue
Benign lesion but highly expansile and destructive fibrovascular neoplasms of the nose among adolescent males
Juvenile Nasopharyngeal Angiofibroma - massive epistaxis
Tx for Juvenile Nasopharyngeal Angiofibroma
Angioembolization or open surgery (Weber Ferguson approach)
Removes cervical LN I-V, spinal accessory nerve, IJV, SCM
Radical neck dissection: Crile Procedure
Removes cervical LN I-V
Modified RN/Functional Neck Dissection: Bocca Procedure
Selective neck dissection for oral malignancies
Supraomohyoid (I,II, III)
Selective neck dissection for laryngeal malignancies
Lateral (II, III, IV)
Selective neck dissection for thyroid malignancies
Posterolateral (II, III, IV and V)
Cervical LN with the highest yield for biopsy
Level IV
Majority of lip Ca occurs in the lower lip except?
BCC in the upper lip
Paresthesia in Ca of lip indicates?
Mental nerve involvement
Most common location of tongue Ca
Lateral and ventral surface
Blind biopsies in unknown primary head and neck Ca
Base of tongue, pyriform sinus, tonsillar fossa, nasopharynx
Tx for subglottic laryngeal Ca
Total laryngectomy with bilateral neck dissection (MRND)
True or false: the smaller the salivary gland, the higher the risk of malignancy
True
Most common benign epithelial salivary gland tumor
Pleomorphic adenoma
Most important branch of the facial nerve to preserve
Temporal branch - closes the eyes
Young patients with long standing nodule and symptoms of hyperthyroidism
Toxic Adenoma (Plummer’s Disease) - unilateral lobectomy + isthmusectomy
Given 7-10 days pre-op to decrease vascularity of the thyroid and lessen risk of thyroid storm
Lugol’s iodine solution
Condition to suspect when a patient has recurrent Acute Suppurative Thyroiditis
Persistent pyriform sinus fistula - 3rd branchial cleft anomaly
Autoimmune disorder involving HLA-B8 and HLA-DR3
Grave’s Disease
Autoimmune disorder involving CD 8 T-helper cells, HLA-B8 HLA-DR3 and HLA-DR 5
Chronic thyroiditis or Hashimoto’s Lymphocytic Thyroiditis
Most common inflammatory disorder of the thyroid gland and leading cause of hypothyroidism
Hashimoto’s Thyroiditis - diffuse infiltration by small lymphocytes and plasma cells
Presentation is a painless, hard anterior neck mass with compressive symptoms in weeks
Reidel’s thyroiditis - invasive fibrous thrombosis, diagnose through open biopsy and treat with wedge excision
FNAB: orphan annie nuclei, psammoma bodies
Papillary Thyroid Ca
Most important prognostic factor in Papillary thyroid Ca
Age
Thyroid Ca that cannot be diagnosed by FNAB
Follicular and Hurthle Cell Ca
Thyroid Ca common in iodine deficient areas
Follicular Ca - minimum Tx is lobectomy+isthmusectomy
Dx of Follicular Ca and Hurthle Cell Ca
Capsular and vascular invasion
Tx for unresectable, locally invasive or recurrent disease and for bony metastases
External beam RT - involves carotids and prevertebral fascia
When are thyroglobulin levels measured post-op?
6 months initially then annually - increased levels is suggestive of metastatic or persistent normal thyroid tissue
Ca that arises from the parafollicular or C cells locate at the superolateral lobes of the thyroid gland
Medullary Thyroid Ca
Medullary Thyroid Ca premalignant lesion for familial cases
C Cell hyperplasia
Familial MTC is secondary to?
Germ line mutation at the ret proto oncogene
Earliest symptom of hypocalcemia
Perioral numbness
Blood supply of parathyroids
Inferior thyroid artery - from thyrocervical trunk
Most common location of ectopic parathyroids
Paraesophageal
Most common cause of primary hyperparathyroidism
Parathyroid adenoma - only 1 gland involved
Pentad of Primary Hyperparathyroidism
Kidney stones, painful bones, abdominal groans, psychic moans, and fatigue overtones
Preoperative localization test for primary hyperparathyroidism
Sestamibi scan
Mainstay Tx for hypercalcemic crisis
IV 0.9% saline hydration to dilute the calcium
Secondary hyperparathyroidism happens among?
Patients with chronic renal failure
Level of esophagus
From C6 to T1
Relation of Vagus nerve to the esophagus
Left vagus - anterior surface, Right vagus - posterior surface
Hernia of the abdominal part of the esophagus and part of stomach
Hiatal hernia
Hernia of the fundus or body of the stomach
Paraesophageal hernia
Histology of the esophagus
Stratified squamous non-keratinized epithelium
Definitive Tx for GERD
Nissen Fundoplication - 360 degree wrap
Esophageal lengthening procedure
Collis gastroplasty
Procedure that anchors the esophagus to its new position in the crura
Hill posterior gastropexy
Borchardt’s Triad: indicative of incarcerated intra thoracic stomach
Chest pain, retching with inability to vomit, inability to pass NGT
Most common esophageal diverticula
Zenker’s Diverticula - found in Killian’s Triangle
Killian’s Triangle
Area of potential weakness situated behind the esophagus at the level of the cricopharyngeus muscle
Most common esophageal motility disorder
Achalasia - due to neurogenic degradation
Triad of Achalasia
Hypertensive LES, aperistalsis of esophageal body, failure of LES to relax
Gold standard in diagnosing Achalasia
Manometry
Tx for Achalasia
Heller’s Myotomy + Partial fundoplication