Anatomy Flashcards
Dichorionic/diamniotic
Fuse or incomplete division of morula (1-3 days)
Monochorionic/Diamniotic
Incomplete separation of fusion of blastocysts (4-8 days)
Monochorionic/monoamniotic
Incomplete division or fusion of implanted blastocyst(8-13 days)
Conjoined twins
Formed embryonic disc incomplete division of fusion
Twin twin transfusion syndrome
Monochorionic/diamniotic
Recepient-increases urine production/polyhydramnios-volume overload of uterus
Donor-produce less urine/oligohydramanios ..almost no bladder on US. “Stuck twin”
What causes monozygotic
Incomplete fusion or division of embryonic disc
Most common conjoined twin
Thoracopagus
Followed by omphalopagus
Minamata disease
Methylmercury poisoning
Severe neurological syndrome
Spasticity, seizures, mental defiency
Lead poisoning
Learning and behavioral disorders
Fetal alcohol syndrome
Mental and growth retardation and morphogenetic disturbances
Intrauterine growth restriction, mental defiency, microcephalic, ocular anomalies, joint abnormalities, short palpebral fissures, cognitive and neurobehavioral disturbances
Cocain
Microencephaly, neurobehavioral disturbances.
Intrauterine growth restriction, prematurity, microcephalic, cerebral infarction, urogenital anomalies, neurobehavioral disturbances
Streptomycin
CNVIII nerve defects
Diethylstilbestrol
Synthetic non steroidal estrogen once used in pregnancyto prevent breast engorgement.
Risk of vaginal clear cell adenocarcinoma and reproductive tract malformations
Abnormalities of uterus and vagina; cervical erosion and ridges
Lithium
Heart and great vessel abnormalities in utero
Nicotine
Premature delivery, conotruncal defects, urinary tract abnormalities
Androgens and high dose progestogens
Varying degree of masculinization of female fetuses; ambiguous external genitalia (labial fusion and clitoral hypertrophy)
Methotrexate
Intrauterine growth restriction, skeletal and renal defects
Multiple anomalies, skeletal, face, cranium, limbs and vertebral
Misoprostol
Abnormal development of the limbs, ocular defects, cranial nerve defects, and autism spectrum disorders
Phenytoin
Fetal hydantoin syndrome, IUGRI microcephalic, metal retardation, ridged metopic suture, inner epicanthic folds, eyelid ptosis, broad, depressed , nasal bridge, phalangeal hypoplasia
Tetracyclines
Stained teeth, hypoplasia of enamel
Thalidomide
Abnormal development of the limbs; meromelia , Amelia, facial anomalies, systemic
Meromelia-partial absence
Amelia-complete absence
Trimethadione
Abnormal development o the limb, v shaped eyebrows, low ears, cleft lip and or palate
Valproic acid
Craniofacial anomalies, neural tube defects , often hydrocephalus, heart and skeletal defects, poor postnatal cognitive development
Warfarin
Nasal hypoplasia, stipples epiphyses
Polychlorinated biphenyls
IUUGRI, skin discoloration
TORCH viruses
Toxoplasmosis, Other (syphilis, varicella-zoster, parvovirus B19), Rubella, Cytomegalovirus (CMV), and Herpes infections, are some of the most common infections associated with congenital anomalies
Toxoplasma gondii
Microcephalic, mental defiency, microphthalmia, hydrocephalus, chorioretinitis, cerebral calcifications, hearing loss, neurologic disturbances
Jaundice
Treponema palladium
Hydrocephalus, congenital deafness, mental defiency, abnormal teeth and bones,
Varicella
Cutaneous scares, neurologic anomalies, cataracts, microphthalmia, horner syndrome, optic atrophy, nystagmus, chorioretinits, microcephalic, mental defiency, skeletal anomalies
Ionizing radiation
Microcephalic, mental defiency, skeletal anomalies, growth retardation, cataracts
CMV
Microcephalic, chorioretinits, sensorineural loss, delayed psychomotor, and mental development, hepatosplenomegaly, hydrocephalus, cerebral palsy, brain, calcification
Herpes
Skin vesicles and scarring, chorioretinitis, hepatomegaly, thrombocytopenia petechiae, hemolytic anemia, hydranencephaly
Human parvovirus b19
Fetal anemia, nonimmune hydrops fetalis, fetal death