Anatomy Flashcards
Types of Blood Cells: Shape
- E: Biconcave Disk
- L: Irregular
- T: Fragmented
Types of Blood Cells: Produced where?
-E: Bone Marrow
-L: Lymph nodes and spleen
T: Bone Marrow
Types of Blood Cells: Hormones
- E: Erythropoietin
- L:Thymosin, Interluekin, CSF
- T: Thrombopoietin
Types of Blood Cells: Nucleated?
- E: None
- L: Nucleated
- T: None
Type of Blood Cells: Amount?
- E: 4-6 million mm^3
- L: 4800-10,000 mm^3
- T: 150,000-400,000 mm^3
Types of Blood Cells: Function
- E: Transport Blood and Gas
- L: Protect immune system
- T: Blood clotting
Types of Blood Cells: Appearance
- E: Salmon colored
- L: Granular/ Nongranular, clear
- T: Blue
Types of Blood Cells: Proteins
- E: Hemoglobin
- L: Antibodies
- T Fibrogen
Types of Blood Cells: Vitamins
- E: B6, b9, b12
- L: C, E, A
- T: K, B9, B12
Types of Blood Cells: Minerals
- E: Iron/copper
- L: Magnesium
- T: Calcium
Types of Blood Cells: Conditions (more/less)
- E: Polycythemia/ Anemia
- L: Leukemia, leukopenia
- T: Thrombocytosis, Hemophilia
Types of Blood Cells: Life Span
- E: 120 days
- L: 4-30 days
- T: 5-10 days
Types of Blood Cells
- Erythrocytes
- Red Blood Cells
- Leukocytes
- White Blood Cells
- Thrombocytes
- Platelets
- Cell Fragments
Types of Blood Cells: Size
- E: 6 mm^3
- L: 12-15 mm^3
- T: 2-5 mm^3
Erythrocytes
- Main Function is to carry oxygen
- Anatomy of Circulating erythrocytes
- Biconcave discs
- Essentially bags of hemoglobin
- No Nucleus
- Contain very few organelles
Hemoglobin
- Iron-containing protein
- Binds strongly, but reversible, to oxygen (can release and attracts oxygen)
- Each hemoglobin molecule has four oxygen binding sites
- Each erythrocytes has 250 million hemoglobin molecules
- Normal blood contains 12-18 g of hemoglobin per 100 mL blood
Leukocytes
- Crucial in the body’s defense against disease
- These are complete cells, with a nucleus and organelles
- Able to move into and out of blood vessels (diapedesis)
- Can move by ameboid motion
- Can respond to chemicals released by damaged tissues
Leukocytosis
- WBC count about 11,000 leukocytes/ mm^3
- Generally indicates and infection
Leukopenia
- Abnormally low leukocyte level
- Commonly caused by certain drugs such as corticosteroid and anticancer agents
Leukemia
-Bone marrow becomes cancerous, turns out excess WBC
Granulocytes (Types of Leukocytes)
- Granules in their cytoplasm can be stained
- Posses lobed nuclei
- Includes neutrophils, eosinophils,and basophils
Agranulocytes
- Lack of visible cytoplasmic granules
- Nuclei are spherical, oval, and kidney shaped
- Include lymphocytes and monocytes
List of White Bloods Cells from Most to Least Abundant
- Neutrophils
- Lymphocytes
- Monocytes
- Eosinophils
- Basophils
Erythroblastosis Fetalis of the Newborn
- Mom is Rh- and baby is Rh+
- Babies blood seeps into the mom, antibodies are produced to attack the proteins
- Baby dies
Types of Leukocytes
- Granulocytes
- Agranulocytes
Types of Granulocytes
- Neutrophils
- Eosinophils
- Basophils
Neutrophils
- Multi lobed nucleus with fine granules
- Act as phagocytes at active cites of infection
Eosinophils
- Large brick red cytoplasmic granules
- Found in response to allergies and parasitic worms
Basophils
- Phil= protein
- Have histamine contains granules
- Initiates inflammation
Types of Agranulocytes
- Lymphocytes
- Monocytes
Lymphocytes
- Nucleus fills most of the cell
- Play an important role in the immune response
Monocytes
- Largest of the White Blood Cells
- Function as macrophages
- Important in fighting chronic infection
Platelets (Thrombocytes)
- Derived from ruptured multinucleate cells (megakaryocytes)
- Megakaryocytes create thrombocytes
- Needed for the clotting process
Blood
- The only fluid tissue in the human body
- Classified as a connective tissue
- Components:
- Living cells
- Formed elements
- Nonliving matrix
- Plasma
- Living cells
Physical Characteristics of Blood
- Color range:
- Oxygen-rich blood is scarlet
- Oxygen poor blood is dull re
- pH must remain between 7.35-7.45
- Blood temperature is slightly higher than body temperature at 100.4 F
- In a healthy man, blood volume is about 5-6 liters or 6 quarts
- Makes up 8% of body weight
Blood when Centrifuged
- Erythrocytes sink to the bottom (45% of blood, person known as a hemocrit)
- Buffy coat contains Leukocytes and platelets (less than 1% of blood)
- Buffy coat is thin, whitish layer between erythrocytes and plasma
- Plasma rises to the top (55%)
Blood Plasma
- Composed of 90% water
- Includes many dissolved substances
- Nutrients (proteins, lipids, carbs)
- Salts (electrolytes)
- Respiratory gases
- Hormones
- Plasma Proteins
- Waste Products
Plasma Proteins
- Most abundant solutes in plasma
- Most are made by the liver
- Plasma proteins include
- Albumin: Regulates osmotic pressure
- Clotting proteins: help to stem blood loss when a blood vessel is injured
- Antibodies: Help protect the body from pathogens
Acidosis
-Blood becomes too acidic
Alkalosis
-Blood becomes too basic
What happens during Acidosis and Alkalosis?
-In each scenario, the respiratory system and kidneys help restore pH to a normal level
Hematopoiesis
- Blood cell formation
- Occurs in bone marrow
- All blood cells are derived from a common stem cell (hemocytoblasts)
Formation of Erythrocytes
- Unable to divide, grow, or synthesize proteins
- When wore out (die), RBCs are eliminated by phagocytes in the spleen or liver
- Lost cells are replaced by division of hemocytoblasts
Control of Erythrocytes
- Rate is controlled by a hormone (erythropoietin)
- Kidneys produce most erythropoietin as a response to reduced oxygen levels in the blood
- Homeostasis is maintained by negative feedback from blood oxygen levels
Formation of White Blood Cells and Platelets
- Controlled by hormones
- Colony stimulating factors (CSF) and interleukins prompt bone marrow to generate Leukocytes
- Thrombopoietin stimulates production of platelets
Hemostasis
- Stoppage of bleeding resulting from a break in a blood vessel
- Involves 3 phases:
- Vascular spasms (parasympathetic nervous system)
- Platelet plug formation
- Coagulation (blood clotting)
Vascular Spasms
- Vasoconstriction causes blood vessel to spasm (parasympathetic nervous system)
- Spasms narrow blood vessel, decreasing blood loss
Epithalamus
- Forms the roof of the third ventricle
- Houses the pineal body (an endocrine gland)
- Includes the choroid plexus—forms cerebrospinal fluid
Gyruses vs. Sulcuses
- Both make up surface of the brain
- Ridges= Gyruses
- Precentral Gyrus
- Grooves= Sulcuses
- Ex: Central Sulcus
- Ridges= Gyruses
Concussion
- Slight brain injury
- No permanent brain damage
Contusion
- Nervous tissue destruction occurs
- Nervous tissue does not regenerate
Cerebral Edema
- Swelling from the inflammatory response
- May compress and kill brain tissue
Cerebrovascular Accident
- Stroke
- Commonly called a stroke
- The result of a ruptured blood vessel supplying a region of the brain
- Brain tissue supplied with oxygen from that blood source dies
- Loss of some functions or death may result
Alzheimer’s Disease
- Progressive degenerative brain disease
- Mostly seen in the elderly, but may begin in middle age
- Structural changes in the brain include abnormal protein deposits and twisted fibers within neurons
- Victims experience memory loss, irritability, confusion, and ultimately, hallucinations and death
Lobes of the Brain
- Frontal:Motor area
- Occipital: Visual area
- Temporal: Auditory and Olfactory
- Parietal: Primary somatosensory area
Regions of the Brain
- Cerebrum
- Cerebellum
- Diencephalon
- Brain Stem
Cerebrum
- more than half of the brain mass
- made of ridges (gyri) and grooves (sulci)
- composed of four regions: frontal, parietal, occipital, and temporal lobes
- Gray matter: outer layer made up of cell bodies (fibers are Unmylinated axons)
- White matter: fibers deep in the gray matter (Fibers are myelinated axons)
Diencephalon
- Sits of the brainstem
- Made of the thalamus, hypothalamus, and epithalamus
- Relay station for sensory impulses
Brain Stem
- attaches to the spinal cord
- Made of the midbrain, pons, and medulla oblongata
Cerebellum
- two hemispheres with convoluted surfaces
- Provides involuntary coordination of voluntary movements.
Function of the Brain
- part of the CNS
- the brain has interneurons that work to integrate information
- decide if a response to sensory information is needed
Protection of the Brain
- Meninges
- Bone
- Capillaries
- Blood-Brain Barrier
- CSF
Meninges
- The Three Layers
- Dura Mater
- Double-layered external covering
- Periosteum—attached to inner surface of the skull
- Meningeal layer—outer covering of the brain
- Folds inward in several areas - Arachnoid Layer
- Middle layer
- Web-like- Pia Mater - Internal layer - Clings to the surface of the brain
Capillaries
- Allow water, glucose,and essential amino acids to pass from blood to the brain
- Keeps metabolic wastes, toxins, proteins, and most drugs from getting into brain tissue
Blood-Brain Barrier
- Includes the least permeable capillaries of the body
- Excludes many potentially harmful substances
- Useless as a barrier against some substances
- Fats and fat soluble molecules
- Respiratory gases
- Alcohol
- Nicotine
- Anesthesia
Cerebrospinal Fluid
- Similar to blood plasma composition
- Formed by the choroid plexus
- Forms a watery cushion to protect the brain
- Circulated in arachnoid space, ventricles, and central canal of the spinal cord
- Hydrocephalus
- CSF accumulates and exerts pressure on the brain if not allowed to drain
Pons
- Controls breathing
- Also controls circadian rhythms
Thalamus
- Relay station for sensory impulses passing upwards to the sensory cortex
- “sensory switchboard” of the brain; deals with all sense except for smell that gets routed to the limbic system
Hypothalamus
- Plays a role in regulating body temperature, water balance, and metabolism
- Center of many drives and emotions - The reward center of the brain
Cerebral Aqueduct
- the slender cavity of the midbrain
- connects the third and fourth ventricles.
Choroid Plexus
- Forms Cerebrospinal Fluid
- Plexus: a bundle of nerves
Pineal Gland
- Produces melatonin
- helps maintain circadian rhythm
- regulates reproductive hormones
Mammillary Body
-Reflex center involved with olfaction (smell)
Corpora Quadrigemina
-Reflex centers for vision and hearing
Cerebral Peduncle of the Midbrain
-Convey ascending and descending impulses
Medulla Oblongata
- “Med-ic” of the body
- Most vital part of the brain
- Controls many major functions of the body VITAL REFLEXES
- Heart Rate
- Blood Pressure
- Breathing
- Swallowing
- Vomiting
Pituitary Gland
- the most influential gland in the endocrine system controlled by the hypothalamus
- the neuroendocrine gland located beneath the brain
- serves a variety of functions:
- regulation of the gonads
- thyroid
- adrenal cortex
- water balance
- lactation
Roles of the Nervous System
- Sensory Impulses
- To monitor changes occurring inside and outside the body
- Changes = stimuli- Interpretation
- To process and interpret sensory input and decide if action is needed
- Motor Output
- A response to integrated stimuli
- The response activates muscles or glands
- Interpretation
Central Nervous System vs. Peripheral Nervous System
- Central nervous system (CNS)
- Brain
- Spinal cord- Peripheral nervous system (PNS)
- Nerves outside the brain and spinal cord
- Spinal nerves (31 pairs)
- Cranial nerves (12 pairs)
- Nerves outside the brain and spinal cord
- Peripheral nervous system (PNS)
Functional Types of Neurons
- sensory (afferent) neurons: nerve fibers that carry impulses to the CNS from sensory receptors
- motor (efferent) neurons:
- carrying away or from
- carries impulses from the CNS to effector organs, the muscles, and glands. - interneurons:
- called association neurons
- complete the pathway between afferent and efferent neurons.
How are structural Neurons classified?
- irritability (ability to respond to stimuli)
- conductivity (ability to transmit an impulse).
Structural Neurons
- multipolar neurons: several processes extending from the neuron.
- bipolar neurons: neurons that have two processes, and axon and a dendrite.
- unipolar neurons: a single process emerging from the cell body.
Factors that Affect Transmission of a Nerve Impulse
- Myelinated or unmyelinated
- Lack or excess of sodium and potassium
- amount of nodes of ranvier
- Number of poles
Reflex Arc
- Stimulus at distal end of a neuron
- Receptor
- Sensory Neuron
- Spinal cord, Integration center (Interneuron)
- Motor Neuron
- Effector
- Response
- 2 Neuron Reflex Arc
- Sensory straight to effector
- Ex: Knee-Jerk, gagging
- 2 Neuron Reflex Arc
Synapse
- Gap between the two neurons
- Makes sure that the impulse goes in the correct direction
- the region of communication between neurons, or a neuromuscular junction between a neuron and a muscle cell
Saltatory Conduction
- The Impulses Jump
- Fibers that have myelin sheaths conduct impulses much faster because the impulse leaps from node of rancher to node of ranvier along the length of the fiber
- No electrical current can flow across an axon membrane that is insulated by fatty myelin
- Fibers that have myelin sheaths conduct impulses much faster because the impulse leaps from node of rancher to node of ranvier along the length of the fiber
Nissl Substance
-Specialized rough endoplasmic reticulum
Neurofibrils
- Intermediate cytoskeleton
- Maintains cell shape
Dendrites
-conduct impulses toward the cell body
Axons
-conduct impulses away from the cell body