Anatomy Flashcards
Types of Blood Cells: Shape
- E: Biconcave Disk
- L: Irregular
- T: Fragmented
Types of Blood Cells: Produced where?
-E: Bone Marrow
-L: Lymph nodes and spleen
T: Bone Marrow
Types of Blood Cells: Hormones
- E: Erythropoietin
- L:Thymosin, Interluekin, CSF
- T: Thrombopoietin
Types of Blood Cells: Nucleated?
- E: None
- L: Nucleated
- T: None
Type of Blood Cells: Amount?
- E: 4-6 million mm^3
- L: 4800-10,000 mm^3
- T: 150,000-400,000 mm^3
Types of Blood Cells: Function
- E: Transport Blood and Gas
- L: Protect immune system
- T: Blood clotting
Types of Blood Cells: Appearance
- E: Salmon colored
- L: Granular/ Nongranular, clear
- T: Blue
Types of Blood Cells: Proteins
- E: Hemoglobin
- L: Antibodies
- T Fibrogen
Types of Blood Cells: Vitamins
- E: B6, b9, b12
- L: C, E, A
- T: K, B9, B12
Types of Blood Cells: Minerals
- E: Iron/copper
- L: Magnesium
- T: Calcium
Types of Blood Cells: Conditions (more/less)
- E: Polycythemia/ Anemia
- L: Leukemia, leukopenia
- T: Thrombocytosis, Hemophilia
Types of Blood Cells: Life Span
- E: 120 days
- L: 4-30 days
- T: 5-10 days
Types of Blood Cells
- Erythrocytes
- Red Blood Cells
- Leukocytes
- White Blood Cells
- Thrombocytes
- Platelets
- Cell Fragments
Types of Blood Cells: Size
- E: 6 mm^3
- L: 12-15 mm^3
- T: 2-5 mm^3
Erythrocytes
- Main Function is to carry oxygen
- Anatomy of Circulating erythrocytes
- Biconcave discs
- Essentially bags of hemoglobin
- No Nucleus
- Contain very few organelles
Hemoglobin
- Iron-containing protein
- Binds strongly, but reversible, to oxygen (can release and attracts oxygen)
- Each hemoglobin molecule has four oxygen binding sites
- Each erythrocytes has 250 million hemoglobin molecules
- Normal blood contains 12-18 g of hemoglobin per 100 mL blood
Leukocytes
- Crucial in the body’s defense against disease
- These are complete cells, with a nucleus and organelles
- Able to move into and out of blood vessels (diapedesis)
- Can move by ameboid motion
- Can respond to chemicals released by damaged tissues
Leukocytosis
- WBC count about 11,000 leukocytes/ mm^3
- Generally indicates and infection
Leukopenia
- Abnormally low leukocyte level
- Commonly caused by certain drugs such as corticosteroid and anticancer agents
Leukemia
-Bone marrow becomes cancerous, turns out excess WBC
Granulocytes (Types of Leukocytes)
- Granules in their cytoplasm can be stained
- Posses lobed nuclei
- Includes neutrophils, eosinophils,and basophils
Agranulocytes
- Lack of visible cytoplasmic granules
- Nuclei are spherical, oval, and kidney shaped
- Include lymphocytes and monocytes
List of White Bloods Cells from Most to Least Abundant
- Neutrophils
- Lymphocytes
- Monocytes
- Eosinophils
- Basophils
Erythroblastosis Fetalis of the Newborn
- Mom is Rh- and baby is Rh+
- Babies blood seeps into the mom, antibodies are produced to attack the proteins
- Baby dies
Types of Leukocytes
- Granulocytes
- Agranulocytes
Types of Granulocytes
- Neutrophils
- Eosinophils
- Basophils
Neutrophils
- Multi lobed nucleus with fine granules
- Act as phagocytes at active cites of infection
Eosinophils
- Large brick red cytoplasmic granules
- Found in response to allergies and parasitic worms
Basophils
- Phil= protein
- Have histamine contains granules
- Initiates inflammation
Types of Agranulocytes
- Lymphocytes
- Monocytes
Lymphocytes
- Nucleus fills most of the cell
- Play an important role in the immune response
Monocytes
- Largest of the White Blood Cells
- Function as macrophages
- Important in fighting chronic infection
Platelets (Thrombocytes)
- Derived from ruptured multinucleate cells (megakaryocytes)
- Megakaryocytes create thrombocytes
- Needed for the clotting process
Blood
- The only fluid tissue in the human body
- Classified as a connective tissue
- Components:
- Living cells
- Formed elements
- Nonliving matrix
- Plasma
- Living cells
Physical Characteristics of Blood
- Color range:
- Oxygen-rich blood is scarlet
- Oxygen poor blood is dull re
- pH must remain between 7.35-7.45
- Blood temperature is slightly higher than body temperature at 100.4 F
- In a healthy man, blood volume is about 5-6 liters or 6 quarts
- Makes up 8% of body weight
Blood when Centrifuged
- Erythrocytes sink to the bottom (45% of blood, person known as a hemocrit)
- Buffy coat contains Leukocytes and platelets (less than 1% of blood)
- Buffy coat is thin, whitish layer between erythrocytes and plasma
- Plasma rises to the top (55%)
Blood Plasma
- Composed of 90% water
- Includes many dissolved substances
- Nutrients (proteins, lipids, carbs)
- Salts (electrolytes)
- Respiratory gases
- Hormones
- Plasma Proteins
- Waste Products
Plasma Proteins
- Most abundant solutes in plasma
- Most are made by the liver
- Plasma proteins include
- Albumin: Regulates osmotic pressure
- Clotting proteins: help to stem blood loss when a blood vessel is injured
- Antibodies: Help protect the body from pathogens
Acidosis
-Blood becomes too acidic
Alkalosis
-Blood becomes too basic
What happens during Acidosis and Alkalosis?
-In each scenario, the respiratory system and kidneys help restore pH to a normal level
Hematopoiesis
- Blood cell formation
- Occurs in bone marrow
- All blood cells are derived from a common stem cell (hemocytoblasts)
Formation of Erythrocytes
- Unable to divide, grow, or synthesize proteins
- When wore out (die), RBCs are eliminated by phagocytes in the spleen or liver
- Lost cells are replaced by division of hemocytoblasts
Control of Erythrocytes
- Rate is controlled by a hormone (erythropoietin)
- Kidneys produce most erythropoietin as a response to reduced oxygen levels in the blood
- Homeostasis is maintained by negative feedback from blood oxygen levels
Formation of White Blood Cells and Platelets
- Controlled by hormones
- Colony stimulating factors (CSF) and interleukins prompt bone marrow to generate Leukocytes
- Thrombopoietin stimulates production of platelets
Hemostasis
- Stoppage of bleeding resulting from a break in a blood vessel
- Involves 3 phases:
- Vascular spasms (parasympathetic nervous system)
- Platelet plug formation
- Coagulation (blood clotting)
Vascular Spasms
- Vasoconstriction causes blood vessel to spasm (parasympathetic nervous system)
- Spasms narrow blood vessel, decreasing blood loss
Epithalamus
- Forms the roof of the third ventricle
- Houses the pineal body (an endocrine gland)
- Includes the choroid plexus—forms cerebrospinal fluid
Gyruses vs. Sulcuses
- Both make up surface of the brain
- Ridges= Gyruses
- Precentral Gyrus
- Grooves= Sulcuses
- Ex: Central Sulcus
- Ridges= Gyruses
Concussion
- Slight brain injury
- No permanent brain damage
Contusion
- Nervous tissue destruction occurs
- Nervous tissue does not regenerate
Cerebral Edema
- Swelling from the inflammatory response
- May compress and kill brain tissue
Cerebrovascular Accident
- Stroke
- Commonly called a stroke
- The result of a ruptured blood vessel supplying a region of the brain
- Brain tissue supplied with oxygen from that blood source dies
- Loss of some functions or death may result
Alzheimer’s Disease
- Progressive degenerative brain disease
- Mostly seen in the elderly, but may begin in middle age
- Structural changes in the brain include abnormal protein deposits and twisted fibers within neurons
- Victims experience memory loss, irritability, confusion, and ultimately, hallucinations and death
Lobes of the Brain
- Frontal:Motor area
- Occipital: Visual area
- Temporal: Auditory and Olfactory
- Parietal: Primary somatosensory area
Regions of the Brain
- Cerebrum
- Cerebellum
- Diencephalon
- Brain Stem
Cerebrum
- more than half of the brain mass
- made of ridges (gyri) and grooves (sulci)
- composed of four regions: frontal, parietal, occipital, and temporal lobes
- Gray matter: outer layer made up of cell bodies (fibers are Unmylinated axons)
- White matter: fibers deep in the gray matter (Fibers are myelinated axons)
Diencephalon
- Sits of the brainstem
- Made of the thalamus, hypothalamus, and epithalamus
- Relay station for sensory impulses
Brain Stem
- attaches to the spinal cord
- Made of the midbrain, pons, and medulla oblongata
Cerebellum
- two hemispheres with convoluted surfaces
- Provides involuntary coordination of voluntary movements.
Function of the Brain
- part of the CNS
- the brain has interneurons that work to integrate information
- decide if a response to sensory information is needed
Protection of the Brain
- Meninges
- Bone
- Capillaries
- Blood-Brain Barrier
- CSF
Meninges
- The Three Layers
- Dura Mater
- Double-layered external covering
- Periosteum—attached to inner surface of the skull
- Meningeal layer—outer covering of the brain
- Folds inward in several areas - Arachnoid Layer
- Middle layer
- Web-like- Pia Mater - Internal layer - Clings to the surface of the brain
Capillaries
- Allow water, glucose,and essential amino acids to pass from blood to the brain
- Keeps metabolic wastes, toxins, proteins, and most drugs from getting into brain tissue
Blood-Brain Barrier
- Includes the least permeable capillaries of the body
- Excludes many potentially harmful substances
- Useless as a barrier against some substances
- Fats and fat soluble molecules
- Respiratory gases
- Alcohol
- Nicotine
- Anesthesia
Cerebrospinal Fluid
- Similar to blood plasma composition
- Formed by the choroid plexus
- Forms a watery cushion to protect the brain
- Circulated in arachnoid space, ventricles, and central canal of the spinal cord
- Hydrocephalus
- CSF accumulates and exerts pressure on the brain if not allowed to drain
Pons
- Controls breathing
- Also controls circadian rhythms
Thalamus
- Relay station for sensory impulses passing upwards to the sensory cortex
- “sensory switchboard” of the brain; deals with all sense except for smell that gets routed to the limbic system
Hypothalamus
- Plays a role in regulating body temperature, water balance, and metabolism
- Center of many drives and emotions - The reward center of the brain
Cerebral Aqueduct
- the slender cavity of the midbrain
- connects the third and fourth ventricles.
Choroid Plexus
- Forms Cerebrospinal Fluid
- Plexus: a bundle of nerves
Pineal Gland
- Produces melatonin
- helps maintain circadian rhythm
- regulates reproductive hormones
Mammillary Body
-Reflex center involved with olfaction (smell)
Corpora Quadrigemina
-Reflex centers for vision and hearing
Cerebral Peduncle of the Midbrain
-Convey ascending and descending impulses
Medulla Oblongata
- “Med-ic” of the body
- Most vital part of the brain
- Controls many major functions of the body VITAL REFLEXES
- Heart Rate
- Blood Pressure
- Breathing
- Swallowing
- Vomiting
Pituitary Gland
- the most influential gland in the endocrine system controlled by the hypothalamus
- the neuroendocrine gland located beneath the brain
- serves a variety of functions:
- regulation of the gonads
- thyroid
- adrenal cortex
- water balance
- lactation
Roles of the Nervous System
- Sensory Impulses
- To monitor changes occurring inside and outside the body
- Changes = stimuli- Interpretation
- To process and interpret sensory input and decide if action is needed
- Motor Output
- A response to integrated stimuli
- The response activates muscles or glands
- Interpretation
Central Nervous System vs. Peripheral Nervous System
- Central nervous system (CNS)
- Brain
- Spinal cord- Peripheral nervous system (PNS)
- Nerves outside the brain and spinal cord
- Spinal nerves (31 pairs)
- Cranial nerves (12 pairs)
- Nerves outside the brain and spinal cord
- Peripheral nervous system (PNS)
Functional Types of Neurons
- sensory (afferent) neurons: nerve fibers that carry impulses to the CNS from sensory receptors
- motor (efferent) neurons:
- carrying away or from
- carries impulses from the CNS to effector organs, the muscles, and glands. - interneurons:
- called association neurons
- complete the pathway between afferent and efferent neurons.
How are structural Neurons classified?
- irritability (ability to respond to stimuli)
- conductivity (ability to transmit an impulse).
Structural Neurons
- multipolar neurons: several processes extending from the neuron.
- bipolar neurons: neurons that have two processes, and axon and a dendrite.
- unipolar neurons: a single process emerging from the cell body.
Factors that Affect Transmission of a Nerve Impulse
- Myelinated or unmyelinated
- Lack or excess of sodium and potassium
- amount of nodes of ranvier
- Number of poles
Reflex Arc
- Stimulus at distal end of a neuron
- Receptor
- Sensory Neuron
- Spinal cord, Integration center (Interneuron)
- Motor Neuron
- Effector
- Response
- 2 Neuron Reflex Arc
- Sensory straight to effector
- Ex: Knee-Jerk, gagging
- 2 Neuron Reflex Arc
Synapse
- Gap between the two neurons
- Makes sure that the impulse goes in the correct direction
- the region of communication between neurons, or a neuromuscular junction between a neuron and a muscle cell
Saltatory Conduction
- The Impulses Jump
- Fibers that have myelin sheaths conduct impulses much faster because the impulse leaps from node of rancher to node of ranvier along the length of the fiber
- No electrical current can flow across an axon membrane that is insulated by fatty myelin
- Fibers that have myelin sheaths conduct impulses much faster because the impulse leaps from node of rancher to node of ranvier along the length of the fiber
Nissl Substance
-Specialized rough endoplasmic reticulum
Neurofibrils
- Intermediate cytoskeleton
- Maintains cell shape
Dendrites
-conduct impulses toward the cell body
Axons
-conduct impulses away from the cell body
Axon Terminals
- Axonal terminals contain vesicles with neurotransmitters
- Axonal terminals are separated from the next neuron by a gap
Myelin Sheath
-whitish, fatty material covering axons
Schwann Cells
-produce myelin sheaths in jelly roll–like fashion
Nodes of Ranvier
-gaps in myelin sheath along the axon
Axon Hillock
-conelike structure, where the axon arises from
Collateral Branch
-Split in an axon that allows the impulse to travel to another area
Neuroglia Cells
- the nonneuronal tissue of the CNS that performs supportive and other functions
- support, insulate, and protect delicate neurons.
Neuroglia Cell Types
- Astrocytes
- Ependymal
- Microglia
- Oligodendrocytes
Astrocytes
- star-shaped cells that make up most neural tissue
- form a living barrier between capillaries and neurons
- help to protect the neurons from harmful substances that might be in the blood
Microglia
- spider-like phagocytes that monitor the Health of nearby neurons
- dispose of debris, including dead brain cells and bacteria
Ependymal Cells
- lines the central cavities of the brain and spinal cord
- fluid forms a protective cushion around the CNS.
Oligodendrocytes
-flat extensions that wrap around neurons producing the myelin sheath.
Conduction of a nerve impulse
- Permeable axon receives an impulse
- Sodium goes in and potassium goes out
- Creates local depolarization
- The axon is fully depolarizer, which creates action potential (travels down the axon)
- Axon repolarizes by bringing potassium back in and sending sodium out
Multiple Sclerosis
- The myelin sheaths around the fibers are gradually destroyed, converting to hard sheaths called scleroses
- Electrical current is short-circuited
- Protein component of the sheath is attacked
- Visual & speech disturbances, loss of ability to control muscles (Increasingly disabled)
Ciliary Body
-Smooth muscle attached to lens
Ciliary Zonule
-suspensory ligament that attaches the lens to the ciliary body in the anterior eye
Cornea
- Transparent, central anterior portion
- Allows for light to pass through -Repairs itself easily
- The only human tissue that can be transplanted without fear of rejection
Iris
-regulates amount of light entering eye
Pupil
-rounded opening in the iris
Aqueous Humor
-Watery fluid found between lens and cornea
-Similar to blood plasma
-Helps maintain intraocular pressure
-Provides nutrients for the lens and cornea
-Reabsorbed into venous blood through the scleral venous sinus, or canal of
Schlemm
Lens
- Biconvex crystal-like structure
- Held in place by a suspensory ligament attached to the ciliary body
Canal of Schlemm
-Aqueous humor fluid is reabsorbed into venous blood
Vitreous Humor
- Gel-like substance posterior to the lens
- Prevents the eye from collapsing
- Helps maintain intraocular pressure
Sclera
- White connective tissue layer
- Seen anteriorly as the “white of the eye”
Choroid
- blood-rich nutritive layer in the posterior of the eye
- Pigment prevents light from scattering
Retina
- Outer pigmented layer
- Inner neural layer
- Contains receptor cells (photoreceptors)
- Rods- Images - Cones-Colors
Fovea Centralis
-area of the retina with only cones
Optic Nerve
-Receives impulses for interpreting sight
Central Artery and Vein of the Retina
-Vascularizes the eye
Optic Disc
- Blindspot
- where the optic nerve leaves the eyeball
- Cannot see images focused on the optic disc
Accessory Structures of the Eye
- Eyelids/Eyelashes
- Conjunctiva
- Lacrimal Apparatus
- Extrinsic Eye Muscles
Eyelids and Eyelashes
- Tarsal glands lubricate the eye
- Ciliary glands are located between the eyelashes
Conjunctiva
- Membrane that lines the eyelids
- Connects to the surface of the eye
- Secretes mucus to lubricate the eye
Properties of Lacrimal Fluid (Lacrimal Apparatus)
- Dilute salt solution (tears)
- Contains antibodies and lysozyme
Function of Lacrimal Apparatus
- Protects, moistens, and lubricates the eye
- Empties into the nasal cavity
Lacrimal Apparatus (Parts)
- Lacrimal gland—produces lacrimal fluid
- Lacrimal canals—drain lacrimal fluid from eyes
- Lacrimal sac—provides passage of lacrimal fluid towards nasal cavity
- Nasolacrimal duct—empties lacrimal fluid into the nasal cavity
Cones
- Allow for detailed color vision
- Densest in the center of the retina
- Cone Sensitivity:
- Three types of cones
- Different cones are sensitive to different wavelengths
- Red, Green, Blue - Color blindness is the result of the lack of one cone type
Rods
- Most are found towards the edges of the retina
- Allow dim light vision and peripheral vision
- All perception is in gray tones
Night Blindness
-inhibited rod function that hinders the ability to see at night
Glaucoma
-can cause blindness due to increasing pressure within the eye
Hemianopia
- loss of the same side of the visual field of both eyes
- results from damage to the visual cortex on one side only
Cataracts
- when lens becomes hard and opaque
- vision becomes hazy and distorted
Color Blindness
- genetic conditions that result in the inability to see certain colors
- Due to the lack of one type of cone (partial color blindness)
Strabismus
- “cross eyed”
- due to an uneven pull by extrinsic eye muscles that prevents coordination between eyes
Presbyopia
-elasticity of the lens as you age
Emmetropia
-eye focuses images correctly on the retina (normal vision)
Astigmatism
- Images are blurry
- Results from light focusing as lines, not points, on the retina due to
- unequal curvatures of the cornea or lens
Hyperopia
- Farsighted
- Near objects are blurry while distant objects are clear
- Distant objects are focused behind the retina
- Results from an eyeball that is too short or from a “lazy lens”
Myopia
-Nearsighted
-Distant objects appear blurry
-Light from those objects fails to reach the retina and are focused in front of it
=Results from an eyeball that is too long
Pathway of Light Through the Eye
- Light must be focused to a point on the retina for optimal vision
- The eye is set for distance vision (over 20 feet away)
- Accommodation—the lens must change shape to focus on closer objects (less than 20 feet away)
- Image formed on the retina is a real image
- Real images are
- Reversed from left to right
- Upside down
- Smaller than the object
- Real images are
Ophthalmoscope
- Instrument used to illuminate the interior of the eyeball
- Can detect diabetes, arteriosclerosis, degeneration of the optic nerve and retina
The Ear
- Houses two senses
- Hearing
- Equilibrium (balance)- Receptors are mechanoreceptors
- Different organs house receptors for each sense
Auricle
- Surrounds the auditory canal opening
- ”Ear” part
Auditory Canal
(external acoustic meatus)
- Narrow chamber in the temporal bone
- Lined with skin and ceruminous (wax) glands
- Ends at the tympanic membrane
Tympanic Membrane
- Hit w/ sound waves from auditory canal
- Vibrates w/ sound hits
Hammer
(malleus) :
- Sends vibration from eardrum to anvil
- Part of the ossicles
Anvil
(incus) :
- Sends vibration to stirrup
- Part of the ossicles
Stirrup
- (Stapes):
- Sends vibration to the inner ear
- Part of the ossicles
Vestibulocochlear Nerve
- both hearing and balance and brings information from the inner ear to the brain
- A human’s sense of equilibrium is determined by this nerve
Semicircular Canals
-Responds to rotational movements (angular acceleration)
Oval Window and Round Window
- Opening in the middle ear
- Release pressure in the ear
Cochlea
- cavity of the inner ear resembling a snail shell
- houses the hearing receptor
Vestibule
- Between semicircular canal & cochlea
- Responds to changes in the position with respect to gravity
Pharynogtympanic Tube
- tube that connects the middle ear and the pharynx
- allows pressure to be equalized on both sides of the eardrum
Trace sound Ear –> Brain
- Auricle (pinna)
- Auditory Canal
- Tympanic Membrane (eardrum)
- Malleus, Incus, Stapes (Amplification in middle ear
- Oval Window
- Fluid in cochlear canals (Organ of Corti Stimulated)
- Cochlear nerve brings impulse to the temporal lobe
Outer, Inner, and Middle Ear
- Outer:
- Auricle
- Auditory Canal- Middle:
- Tympanic Membrane (eardrum)
- Hammer (malleus)
- Middle:
- Anvil (Incus)
- Stirrup (Stapes)- Inner:
- Semicircular Canal
- Cochlea
- Vestibule
- Inner:
Organ of Corti/ Mechanisms of Hearing
- Organ of Corti:
- Located within the cochlea
- Receptors = hair cells on the basilar membrane
- Gel-like tectorial membrane is capable of bending hair cells
- Cochlear nerve attached to hair cells transmits nerve impulses to auditory cortex in temporal lobe - Vibrations from sound waves move tectorial membrane
- Hair cells are bent by the membrane
- An action potential starts in the cochlear nerve
- Continued stimulation can lead to adaptation
Organs of Equilibrium
- Equilibrium receptors of the inner ear are called the vestibular apparatus
- Vestibular apparatus has two functional parts
- Static Equilibrium
- Dynamic Equilibrium
- Vestibular apparatus has two functional parts
Static Equilibrium
(Non-moving):
- Maculae—receptors in the vestibule - Report on the position of the head - Send information via the vestibular nerve - Anatomy of the maculae - Hair cells are embedded in the otolithic membrane - Otoliths (tiny stones) float in a gel around the hair cells - Movements cause otoliths to bend the hair cells
Dynamic Equilibrium
(Moving):
- Crista ampullaris—receptors in the semicircular canals - Tuft of hair cells - Cupula (gelatinous cap) covers the hair cells - Action of angular head movements - The cupula stimulates the hair cells - An impulse is sent via the vestibular nerve to the cerebellum
Location & Orientation (Heart)
Location
- Thorax between the lungs in the inferior mediastinum - Mediastinum: Cavity inside the thoracic cavity - Orientation - Pointed apex directed toward left hip - Base points toward right shoulder - About the size of your fist (1 pound)
Three Layers of the Heart Wall
- Epicardium (Protection)
- Outside layer
- This layer is the visceral pericardium
- Connective tissue layer
- Myocardium
- Middle layer
- Mostly cardiac muscle
- Endocardium
- Inner layer
- Endothelium (smooth)
Function of Heart/Circulation
- deliver oxygen and nutrients throughout the body (lipids, proteins, carbs, nucleic acids, water)
- remove carbon dioxide and other waste products
Conduction of the Heart
- SA node
- Sends signals to AV node and left atrium
- Av node
- Go through the Bundle of His
- To bundle branches
- to Purkinje Fibers
* Sometimes there is a heart block (blocks the transmission)
Blood Pressure
- Blood Pressure: Measurements by health professionals are made based on the pressure in large arteries.
- Systolic: Peak of ventricular contraction
- Diastolic: Ventricles are relaxed
What affects Blood Pressure?
- ANYTHING can affect a person’s BP
- Some potential factors that affect BP:
- Age, weight, time of day, exercise, body position, emotional state
- Neural factors: autonomic nervous system adjustments (sympathetic division)
- Renal factors: regulation by altering blood volume, hormone control (renin)
- Temperature (heat = vasodilating effect), (cold = vasoconstricting effect)
- Chemicals & Diet can lead to increases or decreases in BP
Function of Blood Vessels
- Transport blood to the tissues and back
- Carry blood away from the heart
- ARTERIES: walls of arteries are the thickest
- ARTERIOLES - Exchange between tissues and blood
- CAPILLARY BED: consist of two types of vessels
- Vascular shunt- directly connecting arteriole to venule
- True capillaries- exchange vessels; oxygen and nutrients cross to cells, while carbon dioxide and metabolic waste cross into blood - Return blood toward the heart
- VENULES
- VEINS: lumens of veins are large, have valves that prevent backflow, skeletal muscle “milks” blood in veins toward the heart
Microscopic Anatomy of Blood Vessels
- Three layers also called tunics:
- tunic intima (endothelium)
- tunic media (smooth muscle, sympathetic NS)
- tunic externa (fibrous connective tissue)
Major Arteries and Veins
- Aorta: Largest ARTERY in the body, leaves from the left ventricle of the heart
- Superior and Inferior Vena Cava: VEINS that enter the right atrium of the heart
- Superior VC: drains the head and arms
- Inferior VC: drains the lower body
Electrocardiogram
- Depolarization:
- Changing the polarity of the nerve (sodium & hydrogen involved)
- Stimulating the nerve
- P wave (Depolarization of atriums) - QRS wave (Depolarization of ventricles)
- Repolarization:
- Back to the original stage
- T wave (Repolarization of entire heart)
Lub-Dub (Heart Sounds)
- Lub: closing of the tricuspid and bicuspid valves (AV Valves)
- Dub: Closing of the aortic and pulmonary semilunar valves
Atherosclerosis
- Hardening of the Blood Vessels
- Slowing of blood flow
- Collapsing muscles around veins
- changes in the walls of large arteries consisting of lipid deposits on the artery walls- The early stage of arteriosclerosis and increased rigidity.
- junk that’s getting in you, aging if blood vessels- everything is slowing down, circulation doesn’t go as well caused by stressed(mothers who had babies, jobs)
Organs of the Digestive System
- Two main groups
- Alimentary canal (gastrointestinal tract) —continuous coiled hollow tube
- Accessory: digestive organs
Organs of the Alimentary Canal (GI Tract)
- Pathway from mouth to anus (food passes through)
- Mouth
- Pharynx
- Esophagus
- Stomach
- Small Intestine (97% of digestion)
- Large Intestine
- Anus
Mouth (Oral Cavity) Anatomy
- Lips (Labia): Protect the anterior opening
- Cheeks: form lateral walls (buccal cavity)
- Hard Palate: Forms the anterior roof
- Soft Palate: forms posterior roof
- Uvula: Fleshy projection of the soft palate (Lymph tissue)
Mouth Philosophy
- Mastication: Chewing of food
- Mixing masticated food with saliva (bolus)
- Initiation of swallowing by the tongue
- Tongue rolls back
- Larynx rises
- Constriction
- Deglutition (swallowing)
- Allows for sense of taste
Pharynx Anatomy
- Nasopharynx: Not pharynx of the digestive system
- Oropharynx: Posterior to the oral cavity
- Laryngopharynx: Below the Oropharynx and connected to the esophagus
Teeth (Function)
- Function is the masticate (chew food)
- Humans have two sets of teeth
- Deciduous (baby or “milk” teeth)
- 20 teeth are fully formed by age 2
Permanent Teeth
- Replace deciduous teeth between ages 6 and 12
- A full set of 32 teeth, but some people do not have wisdom teeth (third molars)
- If they do emerge, the wisdom teeth appear between ages 17-25
Classifications of Teeth
- Incisors (cutting)
- Canines ( tearing or piercing)
- Premolars (grinding)
- Molars (grinding)
Regions of the Tooth
- Crown (exposed part)
- Neck (region in contact with gums)
- Root (attaches tooth to periodontal membrane)
Crown
- Enamel: hardest substance in the body
- Dentin: Found deep to the enamel and forms the bulk of the tooth
- Pulp Cavity: Contains connective tissue, blood vessels, and nerve fibers
- Root canal: Where the pulp cavity extends into the root
Neck
- Region in contact with the gum
- Connects crown to root
Root
- Cementum: Covers outer surface
- Attaches the tooth to the periodontal membrane
Salivary Glands
- Three pairs of salivary glands empty secretions into the mouth
- Parotid glands: In front of the ear
- Submandibular: Below the mandible (anterior)
- Sublingual: Below the tongue (posterior)
- In back of the submandibular
Saliva
- Mixture of Mucus and serous fluids
- Helps to form a food bolus
- Contains salivary amylase to begin starch digestion
- Dissolves chemicals so they can be tasted
Pharynx Physiology
-Serves as a passageway for air and food
-Food is propelled to the esophagus by two muscle layers
-Longitudinal inner layer
-Circular outer layer
-Food movement is by alternating contractions of the muscle layers
(Peristalsis: wave-like contractions)
Esophagus Anatomy and Physiology
- Anatomy:
- About 10 inches long
- Runs from pharynx to stomach through the diaphragm
- Physiology:
- Conducts food by peristalsis (slow rhythmic squeezing)
- Passageway for food only (respiratory system branches off after the pharynx)
Layers of the Alimentary Canal Organs
- Mucosa
- Submucosa
- Muscalaris Externa
- Serosa
Mucosa
- Innermost, moist membrane consisting of surface epithelium
- Surface epithelium
- Small amount of connective tissue (lamina propria)
- Small smooth muscle layer)
Submucosa
- Just beneath the mucosa
- Soft connective tissue with blood vessels, nerves endings, and lymphatics
Muscularis Externa
- Smooth Muscle
- Inner circular layer
- Outer longitudinal layer
Serosa
- Outermost layer of the wall that contains fluid-producing cells
- Visceral peritoneum: Outermost layer that is continuous with the innermost layer
- Parietal Peritoneum: Innermost layer that lines the abdominopelvic cavity
Alimentary Canal Nerve Plexus
- Bundle of nerves
- Two important nerve Plexuses serve the alimentary canal
- Both are part of the autonomic nervous system
- Submucosal nerve plexus
- Myenteric nerve plexus
- Function is to regulate mobility and secretory activity of the GI Tract organs
Small Intestine
- The body’s major digestive organ (19-21 feet)
- Site of nutrient absorption into the body
- Function: Chemical Digestion
- Muscular tube extending from the pyloric sphincter to the ileocecal valve
- Suspended from the posterior abdominal wall by the mesentery tissue
Chemical Digestion of the Small Intestine
- Chemical digestion begins in the small intestine
- Enzymes are produced by
- Intestinal glands
- Pancreas
- Pancreatic ducts carry enzymes to the small intestine
- Bile, formed by the liver, enters via the common bile duct (emulsification)
What do certain nutrients break down to?
- Protein–> amino acids
- Carbohydrates–> Monosaccharides
- Lipids–> Fatty acids and glycerol
- Nucleic acids–> nucleotides
Small Intestine Anatomy
- Three Structural modifications that increase surface area
- Microvilli: Tiny projections of the plasma membrane (create a brush boarder appearance)
- Villi: Fingerlike structures formed by the mucosa
- Circular folds (plicae circulares) deep folds of the mucosa and Submucosa
Lacteal
- Absorbs fatty acids and glycerol
- Makes lymph tissue (and lymph fluid)
- Lymph makes antibodies
Intestinal Juices
- Sucrase: sucrose–> glucose
- Lactase: lactose –> glucose
- Maltase: maltose –> glucose
Subdivisions of the Small Intestine
- Duodenum (1 foot)
- Attached to the stomach
- Curves around the head of the pancreas
- Jejunum (8-10)
- Attaches anteriorly to the duodenum
- Illeum (longest part)
- Extends from the Jejunum to large intestine
Stomach Anatomy
- Located on the left side of the abdominopelvic cavity
- Food enters at the cardioesophageal sphincter
- Food (chyme) empties into the small intestine at the pyloric sphincter (valve)
Regions of the Stomach
- Cardiac region: near the heart
- Fundus: Expanded portion lateral to the cardiac regions
- Body: midportion
- Pylorus: funnel-shaped terminal end
Rugae
-Internal folds of mucosa
External Regions of the stomach
- Lesser curvature: concave (curving in) medial surface
- Greater curvature: convex (curving out) lateral surface
Layers of the Peritoneum Attached to the Stomach
- Lesser Omentum: Attaches the liver to the lesser curvature
- Greater Omentum: Attaches the great curvature to the posterior body wall
- Contains fat to insulate, cushion, and protect abdominal organs
- Has lymph nodules containing macrophages
Stomach Philosophy
- Temporary storage tank for food
- Site of food breakdown
- Chemical breakdown of protein begins
- Delivers chyme (Processed food) to the small intestine (to turn into chyle)
Stomach can absorb what?
- Asprin
- Alcohol
Structure of the Stomach Mucosa
- Mucosa is simple columnar epithelium
- Mucous neck cells: produce a sticky alkaline mucus
- Gastric glands: stimulated in gastric pits and secrete gastric juice (2 pH)
- Chief cells: Produce protein– digestive enzymes (pepsinogens)
- Parietal cells: produce hydrochloric acid
- Enteroendocrine cells: produce gastrin hormones
Large Intestine
- Large in diameter, but shorter in length, than the small intestine
- Frames the internal abdomen
Amylase
- Enzyme
- Turns a starch into maltose
Peristalysis
-Wavelike movement of a bolus through the pharynx
Digestive System Functions
- Ingestion: Taking in food
- Digestion: Breaking down food both mechanically and chemically
- Absorption: Movement of nutrients into the bloodstream
- Defecation: rids the body of indigestible waste
- Propulsion: swallowing, peristalsis
What is neutralized chyme called?
-Chyle
Cecum and Appendix (Large Intestine Anatomy)
- Cecum: Saclike first part of the large intestine
- Appendix:
- Accumulation of lymphatic tissue that sometimes becomes inflamed (appendicitis)
- Hangs from the cecum
Colon (Large intestine Anatomy)
- Ascending: Travels up right side of abdomen
- Transverse: Across the abdominal cavity
- Descending: Travels down the left side
- Sigmoid: enters the pelvis
Rectum and Anus (Large Intestine Anatomy)
- Rectum and Anal cavity: also in pelvis
- Anus: Opening of the large intestine
- External anal sphincter- formed by skeletal muscle and under voluntary control
- Internal involuntary sphincter- formed by smooth muscle
- These sphincters are normally closed except during defecation
Large Intestine Anatomy
- No villi present
- Goblet cells produce alkaline mucus which lubricates the passage of feces
- Muscularis Externa layer is reduced to three bands of muscle called teniae coli
- These bands cause the wall to pucker into haustra (pocket-like sacs)
Parts of the Large Intestine
- Cecum
- Appendix
- Colon
- Rectum
- Anus
Pancreas
- Found posterior to the parietal peritoneum
- Extends across the abdomen from spleen to duodenum
- Produces a wide variety of digestive enzymes that break down all categories of food
- Enzymes are secreted into the duodenum
- Alkaline fluid introduced with enzymes naturalizes acidic chyme coming from the stomach
- Hormones produced by the pancreas
- Insulin (controls blood sugar level)
- Glucagon (helps stabilize low blood-sugar levels)
Liver
- Largest gland in the body
- Located on the right side of the body under the diaphragm
- Consists of four lobes suspended from the diaphragm and the abdominal wall by the falciform ligament: connected to the gallbladder via the common hepatic duct
Muscle for Chewing
- Buccinator
- Temporalis
- Masseter
Chambers of the Heart
- Deoxygenated: Right Side
- Oxygenated: Left
- Atriums: Receive blood (not as muscular)
- Ventricles: Pump blood
- R.V: Pumps Deoxygenated blood to the lungs
- L. V: Pumps Oxygenated blood to the body
- Tricuspid Valve: Allows blood to leave Right Atrium and enter the Right Ventricle
- Bicuspid Valve (Mitral valve): Allows blood to leave Left Atrium and enter the Left Ventricle
- Semilunar Valves: Left & Right; Open when Tricuspid and Bicuspid valves close, allow blood to leave the heart
- RSL: Pulmonary Semilunar
- LSL: Aortic Semilunar
Pathway blood from right atrium to toe
- Right Atrium
- Tricuspid valve
- Right ventricle
- Pulmonary semilunar valve
- Pulmonary trunk
- Pulmonary artery
- Lungs (becomes oxygenated blood)
- Pulmonary veins
- Left atrium
- Bicuspid valve
- Left ventricle
- Aortic semilunar valve
- descending aorta
- Iliac
- Femoral
- Popliteal
- Tibial
- Plantar digital
- Arterioles
- Capillaries
- Back to the heart:
- Venules
- Plantar digital vein
- Tibial vein
- Popliteal vein
- Femoral vein
- Iliac vein
- Inferior vena cava
Pathway of blood right atrium to thumb
- Right Atrium
- Tricuspid valve
- Right ventricle
- Pulmonary semilunar valve
- Pulmonary trunk
- Pulmonary artery
- Lungs
- Pulmonary veins
- Left Atrium
- Bicuspid valve
- Left ventricle
- Aortic semilunar valve
- Aorta
- Brachiocephalic trunk
- Brachiocephalic artery
- Subclavian
- Axillary
- Brachial
- Radial
- Common Palmar Digital
- Arterioles
- Capillaries
- Back to Heart:
- Venules
- Palmar Digital veins
- Radial veins
- Brachial veins
- Axillary veins
- Subclavian veins
- Brachiocephalic veins
- Superior vena cava
Trace light pathway through the eye
- Cornea
- Aqueous Humor
- Lens