Anatomy 4.5 Flashcards

1
Q

Anatomically what is the limbic system?

A

border between the diencephalon and telencephalon; conscious and unconscious regions

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2
Q

What are the regions of the limbic system?

A

1) cingulate gyrus (limbic lobe)
2) parahippocampal gyrus (limbic lobe; houses hippocampal formation and amygdala)
3) medial orbital gyrus (frontal lobe)
4) gyri of temporal lobe

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3
Q

What are the main functions of the limbic system?

A

1) emotional response to smell
2) memory
3) sexual drive

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4
Q

What are the key functional centers of the limbic system?

A

1) hippocampus
2) amygdala
3) lateral septal nuclei (basal nucleus of Meynert)

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5
Q

Which structures make up the limbic lobe?

A

1) cingulate gyrus
2) septal area
3) parahippocampal gyrus

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6
Q

What is the principal effector target of the limbic system?

A

hypothalamus; regulates homeostasis (connected to ANS)

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7
Q

Where does the hypothalamus receive input from?

A
  • most of body
  • olfaction
  • viscera
  • retina
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8
Q

Which structure separates the two sides of the hypothalamus?

A

third ventricle

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9
Q

What is the clinical presentation of destruction to the lateral aspect of the hypothalamus?

A

aphagia (no eating)

adipsia (no drinking)

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10
Q

What is the clinical presentation of destruction to the medial aspect of the hypothalamus?

A

hyperphagia (excess eating)

hyperdipsia (excess drinking)

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11
Q

Which part of the hypothalamus is responsible for the memory circuit?

A

mammilary bodies

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12
Q

Which part of the hypothalamus is responsible for autonomic responses?

A

posterior nucleus

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13
Q

What is the function of the amygdala?

A

fear conditioning**

memory consolidation

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14
Q

Which structure programs the response to not laugh at a funeral?

A

amygdala

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15
Q

What is Kluver-Bucy Syndrome?

A
  • hypersexualized
  • loss of affect/aggression
  • “psychic blindness” aka visual agnosia
  • loss of fear
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16
Q

What is Urbach-Wiethe disease?

A
  • degeneration of amygdala
  • no fear!!
  • patient S.M.
17
Q

What is the main output of the hippocampus?

A

subiculum

18
Q

Which part of the hippocampus is responsible for forming episodic memories?

A

dentate gyrus; think of performance in mazes and neurogenesis!!!

19
Q

Which structure is responsible for the conversion of short term to long term memory?

A

hippocampus

20
Q

What is the most important clinical implication of the hippocampus?

A

susceptible to ischemic necrosis; leads to loss of declarative memory

21
Q

What is Korsakoff’s Syndrome?

A
  • caused by vitamin B1 deficiency (common in alcoholics)
  • anterograde/retrograde amnesia
  • confabulatory tendencies with little to no confusion
  • *mammillary bodies and mediodorsal thalamus