Anatomic Sciences Flashcards
Germ layer of parotid gland
ectoderm
Germ layer of sublingual and submandibular salivary glands derived from
endoderm
Developmental defect derviced from first branchial arch
mandibulofacial dysostosis
DiGeorge syndrome
congenital malformation caused by underdevelopment of 3rd and 4th branchial pouches leading to absence or hypoplasia of the parathyroid glands.
Pts usu. have congenital heart defects and comprised immunity.
hypoplasia
underdevelopment of a tissue or organ
first endocrine gland to appear in embryonic dev. and develops from endoerm invaded by mesenchymal cells
thyroid gland
Primary palate formation or median palatal process:
intermaxillary segment arises as a result of fusion of the two medial nasal processes + frontonasal
Secondary palate formation or lateral palatal process:
maxillary process give rise to two palatal shelves.
Give rise to posterior 2/3 of hard palate.
Neuroectoderm (Neural Tube) Derivatives
CNS Astrocytes Neurophypophysis Pineal gland Retina and optic nerve Oligodendrocytes
Neural Crest Cell Derivatives
Meninges Adrenal medulla Pigment cells Pharyngeal arch carilage ENdocardial cushions Ganglia Schwann cells Parafollicular C cells
Ectoderm
Nails Inner ear Outer ear lens of eye epidermis adenohypophysis hair enamel of teeth mammary glands anal canal below pecinate line parotid gland
Mesoderm derivatives
Heart Blood Dermis Muscles Vessels Adrenal cortex Dura mater bone spleen kidney and ureter
Endodermal derivatives
GI tract: foregut, midgut, hindgut Lung Liver Pancreas Thymus Thyroid Parathyroid Submandibular and sublingual glands Middle ear Auditory tube
Kartagener syndrome
Immotile cilia syndrome.
Characterized by recurrent upper and lower respiratory tract infections.
Golgi apparatus function is two-fold:
- modification of lipids and proteins–glycoproteins are assembled for extracellular use.
- storage and packaging of materials that will be exported from the cell. –“shipping department”
O-linked glycosylations occur in
golgi apparatus
N-linked glycosylations occur in
ER
Lysosomes contain a wide variety of?
glycoprotein hydrolytic enzymes
axoneme
core scaffold of euk. cilia and flagella, made from MT.
Serves as the “skeleton”of these organelles.
“9+2” arrangement= 9 pairs of doublet MT
Cell structures that lack membranes
ribosomes
cytoskeleton
nucleolus
cell structures resp. for steroid hormones
ER
cell structures playing essential role in formation of ribosomes
Nucleolus
Kupffer
specialized macrophage located in the liver. Line the sinusoids and cunction to remove bacteria and toxins that have entered blood through intestinal capillaries.
osteoclasts
specialized macrophage located in the bone; bone reabsorption
microglial
specialized macrophages located in the nervous system
fibroblast produces
collagen and reticular fibers
Leydig produces
testosterone
Sertoli produces
testicular fluid, androgen binding proteins (ABPs)and hormones like inhibin
Tooth germ (3)
enamel organ
dental papilla
dental follicle
enamel organ–>_____—> root form
Hertwig’s rooth sheath
enamel organ—>inner enamel epithelium–>____—>_____
ameloblasts—>enamel
Dental papilla—>_____—–>_____
undifferentiated mesenchymal cells fibroblasts—>pulp
dental follicle —->(3)
cementoblasts
fibroblasts—>PDL
osteoblasts–>alveolar bone
Protein factories of the cell
ribosomes
site of rRNA synthesis
nuceolus
The cytoplasm of osteoblasts appears to be basophilic via normal H&E stain due to the presence of large amounts of
Rough ER
Stained by basic dye (will appear blue or purple) is considered _____. E.g.?
basophilic; nuclues and rough ER due to high DNA/RNA content
Acidophilic is stained by acidic dye (red or pink) e.g.?
mitochondria, lysosome
Mitosis:
Requires _1__ division to complete the process.
Occurs in ___2___cells
The daughter cells have the __3__genetic information as the parent cell.
Crossing over btw c___4___occur
- one
- all somatic cells
- same (2n to 2n)
- does not
Meiosis:
Requires___1___divisions to complete the process
Occurs in ___2__
The daughter cells have ___3__the number of c as the parent cells
The daughter cells are genetically _4__ from the parent cell
Crossing over btw c ___ occur
- two
- germ cells only
- half (2n to n)
- different
- does
Simple Squamous Epi function? e.g.?
Function in gas exchange, lines blood vessels and various membranes
aorta
alveoli in lungs
Simple cuboidal epi function? e.g.?
carries on secretion and absorption
Collecting ducts, proximal, distal tubules of the kidneys
thyroid follicles
Simple columnar epi function?e.g?
Protection, secretion and absorption
small and large intestine, gallbladder, stomach
uterine epithelium
salivary gland striated ducts
internal lining of the majority of the tubular GI tract
Stratified squamous epi function? e.g.?
Protects underlying cells from environmental fluctuations
epidermis of the skin (keratinized)
esophagus
Stratified cuboidal epi e.g.?
Ducts of the sweat glands
Stratified columnar epi e.g.?
can have microvilli
large ducts of salivary glands
male urethra
Pseudostratified columnar epi e.g.
can have cilia and microvilli
upper respiratory tract
transitional epi function and e.g.?
Specialized to undergo distension; helps prevent urinary fluids from diffusing outwards
Bladder
Ureter
Parts of male reproductive system
3 layers of skin:
epidermis-avascular-5 layers
dermis-blood vessels provide nutrients to epidermis. Includes appendages of skin.
hypodermis/subdermis-subcutaneous fatty tissue-artery, vein, sweat gland, pressure receptor. Loose (areolar) CT and adipose tissue
5 layers of epidermis outer to inner
Stratum corneum-dead cells filled with keratin continuously shed and replaced. e.g. nails
Stratum lucidum-only in thick skin of palms and soles
Stratum granulosum-basophilic keratohyalin granules
Stratum spinosum-Dendritic cell (langerhans cells)
Stratum basale-cuboidal to columnra, site of conintuous cellular reproduction. Melanocytes . Least differentiated cells.
Bad Sprinters Get Leg Cramps
Dermis has what CT? and what else
Dense irregular CT
Sensory nerve endings
Tactile cells/Merkel cells (sense of light touch discrimination of shapes and textures) in what epidermis layer
stratum basale
Dermis 2 layers
Papillary- areolar CT-Loose CT-thin and less fibrous
Reticular layer-dense irregular CT-thick and fibrous
3 types of stratified squamous epi found in oral cavity
nonkeratinized > parakeratinized > orthokeratinized
nonkeratinized
selective barrier; acts as a cushion
ass. with lining mucosa (soft palate, buccal and labial mucosa, ventral surface of tongue)
orthokeratinized
masticatory mucosa (hard palate, attached gingiva, dorsal surface of tongue)
parakeratinized
masticatory mucosa
contain keratin and nuclei (unlike orthokeratinized)
2 layers of BM
basal layer
reticular lamina
Collagen Type I
bONE
Principal fiber of the PDL
Collagen Type II
carTWOilage
Collagen Type III
reTHREEicular
Collagen Type IV
Basement membrane (think floor-four)
BM 2 layers
- basal lamina-includes lamina lucida and densa
2. reticular lamina-collagen type III and reticular fibers
Cartilage is composed of cells called___ that are dispersed in a firm, gel-like groud substance called___.
chondrocytes (in depressions in the matrix called lacunae); matrix
Cartilage does or does not have blood vessels?
No blood vessels; gets its nutrients and blood supply through the perichondrium (exception articular cartilage at the synovial join)
3 types of cartilage
Hyaline
Fibrocartilage
Elastic
Hyaline cartilage
In epiphyseal plates, covers the articular surfaces of synovial joints.
Incapable of repair when fractured.
Collagen type II
Fibrocartilage
Found in disc within joints (e.g. TMJ, intervertebral discs, knee joint) and articular surfaces of the clavicle and mandible.
Collagen Type I
Elastic cartilage
Very flexible and found in auricle of ear, external auditory meatus, auditory tube, epiglottis.
Collagen Type II
The matrix is mainly composed of proteoglycans, which consist of ?
glycosaminoglycans and core protein.
Most common types of glycosaminoglycans are
chondroitin sulfate
keratan sulfate
Endochondral ossification- primary ossification responsible for
diaphyses of long bones, short bones, irregular bones
Endochondral ossification-secondary ossification responsible for
epiphyses of long bones and extremities of irregular and flat bones.
Metaphysis separates
diaphyses and epiphyses of long bones until adulthood, when they fuse.
Heterotopic ossification
oformation of bone outside the skeleton.
Disease: myositis ossificans
Endochondral ossification
occurs in long bones, such as limbs; the bone is formed from cartilage.
Increases bone length by continued intersitital growth of cartilage which is then replaced by bone.
e.g. mandible- condyles are formed by endo oss.
Intramembranous ossification
mainly occurs during formation of flat bones of the skull; bone is formed from mesenchyme tissue
e.g. maxilla, frontal bone, clavicles
collagen fibers provide
tensiile strength
ground substance provide
compressive strength
Hyaline cartilage is in fetal skeleton. In adults, remnants are:
articular cartilage-in moveable joints
costal cariltage-sternal ends of the ribs
respiratory carilages-movable external nose and septum, larynx, trachea.
Aponeuroses
are flat fibrous sheets or expanded broad tendons that attach to muscles and serve as the means of origin or insertion of flat muscle.