Anatomic Sciences Flashcards

1
Q

Germ layer of parotid gland

A

ectoderm

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2
Q

Germ layer of sublingual and submandibular salivary glands derived from

A

endoderm

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3
Q

Developmental defect derviced from first branchial arch

A

mandibulofacial dysostosis

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4
Q

DiGeorge syndrome

A

congenital malformation caused by underdevelopment of 3rd and 4th branchial pouches leading to absence or hypoplasia of the parathyroid glands.

Pts usu. have congenital heart defects and comprised immunity.

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5
Q

hypoplasia

A

underdevelopment of a tissue or organ

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6
Q

first endocrine gland to appear in embryonic dev. and develops from endoerm invaded by mesenchymal cells

A

thyroid gland

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7
Q

Primary palate formation or median palatal process:

A

intermaxillary segment arises as a result of fusion of the two medial nasal processes + frontonasal

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8
Q

Secondary palate formation or lateral palatal process:

A

maxillary process give rise to two palatal shelves.

Give rise to posterior 2/3 of hard palate.

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9
Q

Neuroectoderm (Neural Tube) Derivatives

A
CNS
Astrocytes
Neurophypophysis
Pineal gland
Retina and optic nerve
Oligodendrocytes
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10
Q

Neural Crest Cell Derivatives

A
Meninges
Adrenal medulla
Pigment cells
Pharyngeal arch carilage
ENdocardial cushions
Ganglia
Schwann cells 
Parafollicular C cells
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11
Q

Ectoderm

A
Nails
Inner ear
Outer ear
lens of eye
epidermis
adenohypophysis
hair
enamel of teeth
mammary glands
anal canal below pecinate line
parotid gland
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12
Q

Mesoderm derivatives

A
Heart
Blood
Dermis
Muscles
Vessels
Adrenal cortex
Dura mater
bone
spleen 
kidney and ureter
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13
Q

Endodermal derivatives

A
GI tract: foregut, midgut, hindgut
Lung
Liver
Pancreas
Thymus
Thyroid
Parathyroid
Submandibular and sublingual glands
Middle ear 
Auditory tube
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14
Q

Kartagener syndrome

A

Immotile cilia syndrome.

Characterized by recurrent upper and lower respiratory tract infections.

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15
Q

Golgi apparatus function is two-fold:

A
  1. modification of lipids and proteins–glycoproteins are assembled for extracellular use.
  2. storage and packaging of materials that will be exported from the cell. –“shipping department”
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16
Q

O-linked glycosylations occur in

A

golgi apparatus

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17
Q

N-linked glycosylations occur in

A

ER

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18
Q

Lysosomes contain a wide variety of?

A

glycoprotein hydrolytic enzymes

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19
Q

axoneme

A

core scaffold of euk. cilia and flagella, made from MT.
Serves as the “skeleton”of these organelles.
“9+2” arrangement= 9 pairs of doublet MT

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20
Q

Cell structures that lack membranes

A

ribosomes
cytoskeleton
nucleolus

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21
Q

cell structures resp. for steroid hormones

A

ER

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22
Q

cell structures playing essential role in formation of ribosomes

A

Nucleolus

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23
Q

Kupffer

A

specialized macrophage located in the liver. Line the sinusoids and cunction to remove bacteria and toxins that have entered blood through intestinal capillaries.

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24
Q

osteoclasts

A

specialized macrophage located in the bone; bone reabsorption

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25
Q

microglial

A

specialized macrophages located in the nervous system

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26
Q

fibroblast produces

A

collagen and reticular fibers

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27
Q

Leydig produces

A

testosterone

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28
Q

Sertoli produces

A

testicular fluid, androgen binding proteins (ABPs)and hormones like inhibin

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29
Q

Tooth germ (3)

A

enamel organ
dental papilla
dental follicle

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30
Q

enamel organ–>_____—> root form

A

Hertwig’s rooth sheath

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31
Q

enamel organ—>inner enamel epithelium–>____—>_____

A

ameloblasts—>enamel

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32
Q

Dental papilla—>_____—–>_____

A

undifferentiated mesenchymal cells fibroblasts—>pulp

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33
Q

dental follicle —->(3)

A

cementoblasts
fibroblasts—>PDL
osteoblasts–>alveolar bone

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34
Q

Protein factories of the cell

A

ribosomes

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35
Q

site of rRNA synthesis

A

nuceolus

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36
Q

The cytoplasm of osteoblasts appears to be basophilic via normal H&E stain due to the presence of large amounts of

A

Rough ER

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37
Q

Stained by basic dye (will appear blue or purple) is considered _____. E.g.?

A

basophilic; nuclues and rough ER due to high DNA/RNA content

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38
Q

Acidophilic is stained by acidic dye (red or pink) e.g.?

A

mitochondria, lysosome

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39
Q

Mitosis:
Requires _1__ division to complete the process.
Occurs in ___2___cells
The daughter cells have the __3__genetic information as the parent cell.
Crossing over btw c___4___occur

A
  1. one
  2. all somatic cells
  3. same (2n to 2n)
  4. does not
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40
Q

Meiosis:
Requires___1___divisions to complete the process
Occurs in ___2__
The daughter cells have ___3__the number of c as the parent cells
The daughter cells are genetically _4__ from the parent cell
Crossing over btw c ___ occur

A
  1. two
  2. germ cells only
  3. half (2n to n)
  4. different
  5. does
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41
Q

Simple Squamous Epi function? e.g.?

A

Function in gas exchange, lines blood vessels and various membranes
aorta
alveoli in lungs

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42
Q

Simple cuboidal epi function? e.g.?

A

carries on secretion and absorption
Collecting ducts, proximal, distal tubules of the kidneys
thyroid follicles

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43
Q

Simple columnar epi function?e.g?

A

Protection, secretion and absorption
small and large intestine, gallbladder, stomach
uterine epithelium
salivary gland striated ducts
internal lining of the majority of the tubular GI tract

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44
Q

Stratified squamous epi function? e.g.?

A

Protects underlying cells from environmental fluctuations
epidermis of the skin (keratinized)
esophagus

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45
Q

Stratified cuboidal epi e.g.?

A

Ducts of the sweat glands

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46
Q

Stratified columnar epi e.g.?

can have microvilli

A

large ducts of salivary glands

male urethra

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47
Q

Pseudostratified columnar epi e.g.

can have cilia and microvilli

A

upper respiratory tract

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48
Q

transitional epi function and e.g.?

A

Specialized to undergo distension; helps prevent urinary fluids from diffusing outwards
Bladder
Ureter
Parts of male reproductive system

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49
Q

3 layers of skin:

A

epidermis-avascular-5 layers

dermis-blood vessels provide nutrients to epidermis. Includes appendages of skin.

hypodermis/subdermis-subcutaneous fatty tissue-artery, vein, sweat gland, pressure receptor. Loose (areolar) CT and adipose tissue

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50
Q

5 layers of epidermis outer to inner

A

Stratum corneum-dead cells filled with keratin continuously shed and replaced. e.g. nails
Stratum lucidum-only in thick skin of palms and soles
Stratum granulosum-basophilic keratohyalin granules
Stratum spinosum-Dendritic cell (langerhans cells)
Stratum basale-cuboidal to columnra, site of conintuous cellular reproduction. Melanocytes . Least differentiated cells.
Bad Sprinters Get Leg Cramps

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51
Q

Dermis has what CT? and what else

A

Dense irregular CT

Sensory nerve endings

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52
Q

Tactile cells/Merkel cells (sense of light touch discrimination of shapes and textures) in what epidermis layer

A

stratum basale

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53
Q

Dermis 2 layers

A

Papillary- areolar CT-Loose CT-thin and less fibrous

Reticular layer-dense irregular CT-thick and fibrous

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54
Q

3 types of stratified squamous epi found in oral cavity

A

nonkeratinized > parakeratinized > orthokeratinized

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55
Q

nonkeratinized

A

selective barrier; acts as a cushion

ass. with lining mucosa (soft palate, buccal and labial mucosa, ventral surface of tongue)

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56
Q

orthokeratinized

A

masticatory mucosa (hard palate, attached gingiva, dorsal surface of tongue)

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57
Q

parakeratinized

A

masticatory mucosa

contain keratin and nuclei (unlike orthokeratinized)

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58
Q

2 layers of BM

A

basal layer

reticular lamina

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59
Q

Collagen Type I

A

bONE

Principal fiber of the PDL

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60
Q

Collagen Type II

A

carTWOilage

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61
Q

Collagen Type III

A

reTHREEicular

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62
Q

Collagen Type IV

A

Basement membrane (think floor-four)

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63
Q

BM 2 layers

A
  1. basal lamina-includes lamina lucida and densa

2. reticular lamina-collagen type III and reticular fibers

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64
Q

Cartilage is composed of cells called___ that are dispersed in a firm, gel-like groud substance called___.

A

chondrocytes (in depressions in the matrix called lacunae); matrix

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65
Q

Cartilage does or does not have blood vessels?

A

No blood vessels; gets its nutrients and blood supply through the perichondrium (exception articular cartilage at the synovial join)

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66
Q

3 types of cartilage

A

Hyaline
Fibrocartilage
Elastic

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67
Q

Hyaline cartilage

A

In epiphyseal plates, covers the articular surfaces of synovial joints.
Incapable of repair when fractured.

Collagen type II

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68
Q

Fibrocartilage

A

Found in disc within joints (e.g. TMJ, intervertebral discs, knee joint) and articular surfaces of the clavicle and mandible.

Collagen Type I

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69
Q

Elastic cartilage

A

Very flexible and found in auricle of ear, external auditory meatus, auditory tube, epiglottis.

Collagen Type II

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70
Q

The matrix is mainly composed of proteoglycans, which consist of ?

A

glycosaminoglycans and core protein.

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71
Q

Most common types of glycosaminoglycans are

A

chondroitin sulfate

keratan sulfate

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72
Q

Endochondral ossification- primary ossification responsible for

A

diaphyses of long bones, short bones, irregular bones

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73
Q

Endochondral ossification-secondary ossification responsible for

A

epiphyses of long bones and extremities of irregular and flat bones.

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74
Q

Metaphysis separates

A

diaphyses and epiphyses of long bones until adulthood, when they fuse.

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75
Q

Heterotopic ossification

A

oformation of bone outside the skeleton.

Disease: myositis ossificans

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76
Q

Endochondral ossification

A

occurs in long bones, such as limbs; the bone is formed from cartilage.
Increases bone length by continued intersitital growth of cartilage which is then replaced by bone.
e.g. mandible- condyles are formed by endo oss.

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77
Q

Intramembranous ossification

A

mainly occurs during formation of flat bones of the skull; bone is formed from mesenchyme tissue

e.g. maxilla, frontal bone, clavicles

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78
Q

collagen fibers provide

A

tensiile strength

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79
Q

ground substance provide

A

compressive strength

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80
Q

Hyaline cartilage is in fetal skeleton. In adults, remnants are:

A

articular cartilage-in moveable joints
costal cariltage-sternal ends of the ribs
respiratory carilages-movable external nose and septum, larynx, trachea.

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81
Q

Aponeuroses

A

are flat fibrous sheets or expanded broad tendons that attach to muscles and serve as the means of origin or insertion of flat muscle.

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82
Q

Fascia secures

A

muscle to a tendon

83
Q

Sharpey fibers

A

when a tendon or ligament is attached to the bone, the attaching fibers are called sharpey fibers.

84
Q

Essential components of CT

A

Ground substance (proteoglycans-with GAGS and protein core)
fibers
cells

85
Q

CT 2 types

A

Loose

Dense-regular and irregular

86
Q

Loose CT (areolar)

A

irregular or loose arrangements and few fibers.

In papillary dermis

87
Q

Dense regular CT

A

regular arrangements, tightly packed, strong, parallel collagen fibers.
e.g. tendons, ligaments, aponeuroses, fascia, cornea

88
Q

Dense irregular CT

A

tightly packed, strong collagen fibers arranged in an inconsistent or irregular pattern.

Found in dermis (reticular layer), submucosa of GI tract, organ capsules, periosteum

89
Q

Desmosomes aka anchoring junction

A

fasten cells together into strong sheets and attach muscle cells to each other in a muscle. Leave a space separating the plasma membranes

90
Q

Hemidesmosome

A

involves attachment of a cell to an adjacent noncellular surface.

e.g. gingival epithelium or junctional epithelium

91
Q

Tight junctions aka zonula occludens aka occluding junctions

A

plasma membranes of neighboring cells are tightly pressed against each other, this forms a continuous seal around the seal. Prevents leakage.

92
Q

Gap junctions aka communicating junctions

A

Small channels that form direct intercellular connections through which small molecules and ions can flow. Each gap junction is formed by transmembrane proteins called connexins.

93
Q

Adherens junction aka zonula adherens

A

Provide strong mechanical attachments between adjacent cells. Composed of cadherins (connected to actin filaments). Serve as a bridge connecting actin cytoskeleton of neighboring cells through direct interaction.

94
Q

Cartilage can grow in 2 ways

A
  1. interstitial growth

2. appositional growth

95
Q

interstitial growth

A

growth from deep within the tissue by mitosis of each chondrocyte

96
Q

appositional growth

A

layered growth on the outside of tissue from the outer layer of chondroblasts within perichondrium.

Increases bone girth by apposition of new bone subperiosteally.

97
Q

Meissner corpuscle

A

tactile sensation

98
Q

Ruffini corpuscle

A

tactile senation. e.g. skin stretch

99
Q

pacinian corpuscle

A

around nerve to reduce sensitivity

100
Q

Superior cervical ganglion stretches from

A

C1 to C2/C3

101
Q

Superior cervical ganglion para or sym response

A

sympathetic

102
Q

middle cervical ganglion located level of

A

the cricoid cartilage

103
Q

inferior cervical gangion occurs at the

A

C7 vertebral level.

104
Q

mesencephalic nucleus function

A

proprioception of the face (feeling of position of the muscles)

105
Q

Main sensory nucleus aka chief nucleus aka pontine nucleus

A

discriminative touch of the face

106
Q

Spinal nucleus

A

pain/temperature of the face

107
Q

motor nucleus

A

supplies muscles of the 1st branchial arch

108
Q

2 types of cementum

A

Acellular (primary cementum)

Cellular (secondary cementum)

109
Q

Acellular cementum

A
formed at slow rate
no embedded cemtocytes
usu. at coronal 2/3
thinnest at CEJ
Sharpey fiber
110
Q

Cellular cementum

A

covers acellular cementum
faster rate
embedded cementoblasts
us. apical 1/3

111
Q

Dental papilla–>

A

dentin by odontoblasts and pulp tissue

112
Q

dental sac –>

A

cementum by cementoblasts

113
Q

mesoderm of tooth–>

A

alveolar bone by osteoclasts

114
Q

Enamel germ layer?

A

ectodermal

115
Q

Enamel organic matrix

A

mainly of protein, which is rich in proline

116
Q

enamel tufts

A

hypocalcified structures of enamel rods from DEJ

117
Q

enamel spindles

A

short dentinal tubules near DEJ.

118
Q

enamel lamellae

A

partially calcified vertical defects

119
Q

gnarled enamel

A

over the cusps of teeth enamel rods appear twisted around each other in complex arrangement.

120
Q

Structure resp. for root development

A

cervical loop

121
Q

Hertwig sheath derived from

A

inner and outer enamel epithelium of the enamel organ.

122
Q

Outer enamel epi

A

forms periphery of enamel organ.

Outlines shape of the future developing enamel organ

123
Q

Inner enamel epithelium

A

Differentiates into ameloblasts that secrete enamel

124
Q

stratum intermedium

A

essential to enamel formation (prepares nutrients for the ameloblasts)

125
Q

Stellate reticulum

A

Star-shaped cells

Contains intercellular fluid

126
Q

the epithelial rests of malassez are remnants of

A

hertwig epithelial root sheath

127
Q

purpose of hertwig epithelial root sheath is to

A

shape the root and induce dentin formation.

128
Q

Hertwig epithelial root sheath is characterized by

A

formation of cell rests (rests of malassez)

absence of stellate reticulum and stratum intermedium

129
Q

Dentin matrix composed of

A

Collagen Type I
DMP
Phosphophoryn

130
Q

transverse temporal gyrus

A

primary auditory cortex

131
Q

cingulate gyrus

A

emotional processing/memory

132
Q

Uncus

A

primary olfactory cortex (smell)

133
Q

Precentral gyrus

A

conscious motor control

134
Q

H zone

A

thick filaments only

135
Q

A zone

A

thick and think filaments overlap

136
Q

I band

A

thin filaments

137
Q

epithalamaus

A

contains pineal gland which secretes melatonin and the choroid plexus which forms CSF

138
Q

thin filaments

A

troponin, tropomyosin, actin

139
Q

thick filaments

A

light and heavy meromyosin

140
Q

temporomandibular ligament

A

runs down and back of oblique direction limiting degree of jaw opening and initiates translation of the condyle down the aritcular eminence.

141
Q

lymph drainage-middle part of the tongue

A

deep cervical chain lymph nodes

142
Q

lymph drainage-posterior part of the tongue

A

retropharyngeal lymph node

143
Q

Cervical plexus

A

C1-C4
Provides cutaneous innervation to skin of neck, shoulder, upper anterior chest wall.
Have 3 nerve branches-anasa cervicalis, phrinic nerve, great auricular nerve

144
Q

Ansa cervicalis

A

C1-C3

Supplies infrahyoid muscles except thyrohoid which is supplied by by C1 fibers which run with CN XII

145
Q

Phrenic nerve

A

C3-C5

supplies the diaphragm

146
Q

Great auricular nerve

A

C2 and C3

Provides sensory innervation for skin over parotid gland and mastoid process, and both surfaces of outer ear.

147
Q

Brachial plexus

A

C5-C8 and T1
formed in posteror triangle of neck
Has 3 cords: posterior, lateral, medial

148
Q

Lumbar plexus

A

L1-L4
formed in psoas major muscle, the lumbar plexus supplies lower abdomen and parts of the lower limb.
Main branches are femoral and obturator nerves

149
Q

Sacral plexus

A

L4-L5 and S1-S4
Supplies lower back, pelvis, parts of thigh, leg and food.
Main branch is sciatic.

150
Q

Sensory nerve fibers in dental pulp, smallest to largest dameter

A

C-fibers, A-delta, A-beta fibers

151
Q

A-delta fibers

A

myelinated
“first pain signal”
pain to temperature
small diameter

152
Q

C-(nerve)fibers

A
unmyelinated
"second pain"
pain, temperature, itch
polynodal because respond to several stimuli such as muchanical, chemical or thermal stimulation to pulp.
small diameter
153
Q

Parietal lobe ass. with processing

A

tacile sensory information such as pressure, touch, pain

intelligence
language
reading
sensation

154
Q

Frontal lob ass. with

A
thinking
behaviour
intelligence
memory 
movement
155
Q

Temporal lobe ass with

A

behaviour
hearing speech
vision
memory

156
Q

Occipital lobe ass. with

A

vision

157
Q

Dendrites send an impulse where?

A

toward the cell body

158
Q

Axons send the impulse where?

A

away from cell body

159
Q

diencephalon includes what 2 structures

A

thalamus

hypothalamus

160
Q

gray matter

A

unmyelinated nerve cell bodies

161
Q

white matter

A

myelinated nerve fibers

162
Q

ventricles

A

spaces filled with CSF

163
Q

Astrocyte

A

provide structural supposrt

164
Q

PNS cell types

A

satellite cells-support cell bodies

Schwann cells-form myelin

165
Q

Celiac trunk branches into

A

splenic
L gastic
common hepatic

166
Q

Pernicious anemia due to

A

body can’t absorb Vitamin B12 due to weakened stomach lining or autoimmune disease.

167
Q

Aplastic anemia

A

Damage to bone marrow, can’t make enough new blood cells.

168
Q

Hemolytic anemia

A

due to hemolysis, abnormal breakdown of RBC>

169
Q

In adrenergic receptors, most postganglionic sympathic synapses have what as NT?

A

NE

Everything else Ach

170
Q

The esophagus _____ the diaphragm, while the aorta, azygos vein, and thoracic duct _____to it.

A

passes through; pass posterior

171
Q

External intercostal muscles and subcostal muscles

A

raise the ribs during inspiration.

172
Q

Internal intercostal muscles

A

depress the ribs during expiration.

Mainly active during forced respiration.

173
Q

Above superior pharyngeal constrictor

A

auditory tube
levator palatini muscle
ascending palatine artery

174
Q

Between superior and middle constrictors

A

stylopharyngeus muscle
glossopharyngeal nerve
stylohyoid ligament
SS9

175
Q

Between middle and inferior constrictors

A

Internal branch of the superior laryngeal nerve

superior laryngeal artery

176
Q

Below inferior constrictor

A

reccurent laryngeal nerve

inferior laryngeal artery

177
Q

Right lateral excursive movements involves what muscle as prime mover?

A

left lateral pterygoid

178
Q

With condylar neck fracture, muscle contractions might result in displacement of the injured condyle into the

A

infratemporal fossa

179
Q

Filiform

A
Most numerous 
"V" shapedparalleling sulcus terminalis on ant. 2/3
absence of taste buds 
increased keratinization
Serve to grip food.

Trick: I ain’t got no taste for phili

180
Q

Fungiform

A

mushroom/knob-shaped
tip and sides of tongue
CN VII

181
Q

Circumvallate

A

Largest but fest in number (7-12)
inversited V shape
ass. with ducts of Von Ebner glands
CN IX

182
Q

Foliate

A

lateral margins as 2-3 vertical folds
Inn. by CN 7 and 9

Trick: exfoliate sides of body

183
Q

Plummer-Vinson syndrome

A

esophageal webs, glossitis, iron deficiency anemia.

Usu. in postmenopausal women.

184
Q

Intramembranous grows by

A

appositional growth only
In flat bones of skill, mx, clavicles.
does not require the existence of a cartilage bone model

185
Q

Endochondral ossification

A

began as hyaline cartilage before it ossifies.
Bones at base of the skill, condyles, mn, short and long bones
both appositional and intersitital growth.

186
Q

Osteoblasts derived from

A

fibroblastarthros

187
Q

Osteoclast derived from

A

monocytes and mactophages

188
Q

Osteoid vs. bone

A

Osteoid does not have mineralized matrix and has more water content.

189
Q

diarthroses

A

freely (synoval joint)

e.g. tmj

190
Q

synathrosis

A

immovable joint (fibrous joint)

ex. gomphosis-bind teeth to bony sockets, sutures of the skull, syndesmoses (btw radius and ulna).

191
Q

Amphiarthrosis

A

slightly movable (cartilaginous joint)

e.g. pubic symphysis
synchondrosis-united by hyaline and permit no movement but growth in length of bone=epiphyseal cartilage eplate. sternum
symphyses-joined by plated of fibrocarilage and slighly movable-pubic symphysis and intervertebral disc.

192
Q

Nodding yes using what joint

A

atlanto-occipital joint

193
Q

Nodding no using what joint

A

atlantoaxial joint

194
Q

2 types of muscle fibers

A

extrafusal fibers

intrafusal fibers

195
Q

2 types of intrafusal fibers

A

Nuclear bag fibers: detect fast dynamic changes, innervated by group la afferents, larger than nuclear chain, nuclei in a central “bag” region

Nuclear chain fibers-detet static changes, innervated by slower group II afferents, smaller and more numerous than bag fibers and have nuclei arranged in rows.

196
Q

trachea histology

A

ciliated pseudostratified columnar epithelium and mucus-secreting goblet cells.

197
Q

Type I pneumocytes

A

gas exchange in alveoli

198
Q

Type II pneumocytes

A

production and section of surfactant

199
Q

alveolar macrphages

A

or dust cells, type of macrophags found in pulmonary alveolus.

200
Q

plicae circulares aka valves of Kerckring found in

A

jejunum

201
Q

Foregut

A

anything above proximal duodemun and includes spleen
arterial supply:celiac trunk
para inn: vagus
venous drainage: hepatic portal system

202
Q

Midgut

A

all small intestine, some of colon
arterial supply: superior mesenteric artery
venous drainage: hepatic portal system
para inn: vagus

203
Q

Hindgut

A

colon, sigmoid colon, rectum
arterial supply: inferior mesenteric artery
venous drainage: hepatic portal system
para inn: S2-S4