Analgesics/Sedatives/Anticonvulsive Drugs Flashcards
Funtanyl Citrate (Sublimaze) Class
Opiod analgesic ; schedule II drug
Funtanyl Citrate (Sublimaze) Mechanism of Action
Binds to opiate receptors, producing analgesia and euphoria.
Funtanyl Citrate (Sublimaze) Indications
Pain management, anesthesia adjunct
Funtanyl Citrate (Sublimaze) Contraindications
Known hypersensitivity. Use with caution in traumatic brain injury.
Funtanyl Citrate (Sublimaze) Adverse Reactions/ Side effects
Confusion, paradoxical excitation, delirium, drowsiness, CNS depression, sedation, respiratory depression, apnea, dyspnea, dysrhythmias, bradycardia, tachycardia, hypotension, syncope, nausea, vomiting, abdominal pain, dehydration, fatigue
Funtanyl Citrate (Sublimaze) Drug Interactions
Increased respiratory effects when given with other CNS depressants.
Funtanyl Citrate (Sublimaze) Adult Dosage and administration
50 to 100 mcg(1mcg/kg) IM and IV slow push (over 1 to 2 minutes) to a maximum of 150mcg. IN is rapid push.
Funtanyl Citrate (Sublimaze) Pediatric Dosage and administration
1 to 2 mcg/kg IM, IV, or IN slow push(over 1 to 2 minutes) . The safety in children under 2 years has not been established.
Funtanyl Citrate (Sublimaze) Duration of action
onset: 1 to 3 minutes
peak: 3 to 5 minutes
duration: 30 to 60
Funtanyl Citrate (Sublimaze) pregnancy class
C
Funtanyl Citrate (Sublimaze) special considerations
Chest wall rigidity passible with a high dose rapid infusion. A dose of 100mcg of fentanyl citrate is equivalent to 10mg of morphine or 75mg of meperidine.
Ketorolac Tromethamine(Toradol) class
NSAID analgesic
Ketorolac Tromethamine(Toradol) Mechanism of action
Potent analgesic that does not possess any sedative or anxiolytic activities by inhibiting prostaglandin synthesis
Ketorolac Tromethamine(Toradol) Indications
Short term management of moderate to severe pain.
Ketorolac Tromethamine(Toradol) Contraindications
Allergy to salicylates or other NSAIDs. Patients with a history of asthma, bleeding disorders(especially GI related, such as peptic ulcer disease), renal failure.
Ketorolac Tromethamine(Toradol) Adverse reactions/ Side effects
Drowsiness, dizziness, headache, sedation, bronchospasm, dyspnea, edema, vasodilation, hypotension, hypertension, GI bleeding, diarrhea, dyspepsia, nausea.
Ketorolac Tromethamine(Toradol) Drug Interactions
May increase bleeding time in patients taking anticoagulants.
Ketorolac Tromethamine(Toradol) Adult Dosage and Administration
30 to 60 mg IM, 15 to 30mg IV
Ketorolac Tromethamine(Toradol) Pediatric Dosage and Administration
Not recommended
Ketorolac Tromethamine(Toradol) Duration of Action
onset: 10 min
peak: 1 to 2 hours
duration 2 to 6 hours.
Ketorolac Tromethamine(Toradol) pregnancy safety category
C
Ketorolac Tromethamine(Toradol) Special Considerations
Use with caution in older patients due to higher risk of renal and fatal GI adverse reactions. Because it is a salicylate derivative, it is important to use caution if pain is possibly from a traumatic source.
Morphine Sulfate (Roxanol, MS Contin) Class
Opiod analgesic; schedule II drug
Morphine Sulfate (Roxanol, MS Contin) Mechanism of Action
Alleviates pain through CNS action. Suppresses fear and anxiety centers in the brain. Suppresses fear and anxiety centers in the brain. Depresses brain stem respiratory centers. Increases peripheral venous capacitance and decreases preload and after load, which decreases mycardial oxygen demand.
Morphine Sulfate (Roxanol, MS Contin) Indications
Severe heart failure, acute cardiogenic pulmonary edema, chest pain associated with AMI, analgesia for moderate to severe acute and chronic pain.
Morphine Sulfate (Roxanol, MS Contin) Contraindications
Head injury, exacerbated COPD, depressed respiratory drive, hypotension, undiagnosed abdominal pain, decreased level of consciousness, suspected hypovolemia, patients who have taken MAOIs within 14 days.
Morphine Sulfate (Roxanol, MS Contin) Adverse reactions/ Side effects
Confusion, sedation, headache, CNS depression, respiratory depression, apnea, bronchospasm, dyspnea, hypotension, orthostatic hypotension, syncope, bradycardia, tachycardia, nausea, vomiting, dry mouth.
Morphine Sulfate (Roxanol, MS Contin) Drug Interactions
Potentiates sedative effects of phenothiazines. CNS depressants may potentiate effects of morphine. MAOIs may cause paradoxical excitation.
Morphine Sulfate (Roxanol, MS Contin) Adult Dosage and Administration
STEMI: Initial dose of 2 to 4 mg slow IV (over 1 to 5 mins). Repeat Dose: 2 to 8 mg at 5 to 15 min intervals.
NSTEMI/unstable angina: 1 to 5 mg IV push if symptoms not relieved by nitrates, use with caution.
Morphine Sulfate (Roxanol, MS Contin) Pediatric Dosage and administration
0.1 to 0.2 mg/kg per dose IV,IO,IM, subcutaneous. Max of 5mg