Analgesics & Opioids (Laprairie Lecture)

Question 1

Agonist binding to Opioid Receptors reduces ____, inhibits inwardly rectifying K+ channels, & __________ the cell.

Answer 1

cGMP; hyperpolarizes

Question 2

Examples of Endogenous Opioids?

Answer 2

Enkephalin
Dynorphin
Substance P
Endorphin

Question 3

Which country is the number one producer of Opium plants?

Answer 3

Tasmania

Question 4

Cleavage of a ______ functional group renders Codeine into Morphine.

Answer 4

methoxy

Question 5

Phase I metabolism of Codeine, Hydrocodone, Oxycodone & Tramadol are all mediated by what CYP enzyme?

Answer 5

CYP2D6

Question 6

Phase II conjugative reactions of Morphine, Hydromorphone & Oxymorphone are mediated by what enzyme?

Answer 6

UGT2B7

Question 7

Aside from proposed CNS-selective COX inhibition, how else does Tylenol elicit pain relief?

Answer 7

1) Anandamide Reuptake Inhibitor (which serves to boost Endocannabinoid levels)

2) TRPV1 Agonist

Question 8

What CYP enzymes metabolize Tylenol?

Answer 8

CYP2E1, CYP3A4

Question 9

Phase I metabolism of NSAIDs is conducted by what CYP enzymes?

Answer 9

CYP2C9, CYP2D6

Question 10

What distinguishes Endogenous Opioids from Exogenous Opioids?

Answer 10

Endogenous = Peptides

Question 11

Opioids & Cannabinoids both do what same thing to limit pain perception?

Answer 11

Inhibit NT release from Pre-Synaptic Neuron

Question 12

Of the following Opioid Receptors, which one DOES NOT induce respiratory depression when stimulated?

Mu
Kappa
Delta

Answer 12

Delta

Question 13

Of the following Opioid Receptors, which one elicits euphoria when stimulated?

Delta
Mu
Kappa

Answer 13

Mu

Question 14

T or F: There are currently no known Cannabinoid Receptor polymorphisms that affect drug efficacy.

Answer 14

True!

Question 15

An increasing number of this BP triplet can predict the likelihood of one using Cannabis, as well as the severity of Huntington’s Disease if they were to acquire it.

Answer 15

AAT