Analgesics

Question 1

e. g. Paroxetine, Citalopram
- Antidepressant analgesic
- Prevent recycling of neurotransmitters and enhance the signal
- Works well in diseased environment
- Drowsiness, nausea, dry mouth, insomnia, diarrhea, dizziness, reduced libido

Answer 1

Selective Serotonin re-uptake inhibitors

Question 2

e. g. Venlafaxine, Duloxetine
- Antidepressant analgesic
- Prevent recycling of neurotransmitters and enhance the signal
- Highly selective for neuropathic pain
- Prescribed for diabetic neuropathy
- Nausea, dizziness, headache, drowsiness

Answer 2

Serotonin and noradrenaline re-uptake inhibitors

Question 3

• Antiepilleptic analgesic
• Not very effective
• Used in neuralgia and diabetic neuropathies
• Blocks sodium, calcium, GABA and glycine receptors
• Dizziness, diplopia, drowsiness, fatigue, nausea, hepatoxicity

Answer 3

Carbamazepine

Question 4

• Antiepilleptic analgesic
• Works in various neuropathic pain
• Mechanism not fully known- may work the same as carbamazepine?
• Anorexia, dyspepsia, tremor

Answer 4

Gabapentin

Question 5

• Anaesthetics
• Inhibits voltage gated sodium channels or NMDA receptors
• Prevents nervous cell communication
• Used in increasing neuropathic pain and emergency medicine

Answer 5

Lidocaine and Ketamin

Question 6

Side effects of Lidocaine…

Answer 6

CNS effects, respiratory depression, convulsions, hypotension, bradycardia

Question 7

Side effects of Ketamine…

Answer 7

Hypertension, tachycardia, tremor, diplopia, myocardial depression