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FARMACOLOGÍA > Analgésicos > Flashcards

Analgésicos Flashcards

1
Q

Farmacos AINES

A

AAS, ibuprofeno, naproxeno, ketorolaco, diclofenaco, meloxicam, celecoxib

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2
Q

mecanismo de accion de los AINES

A

inhibicion de COX-1 y COX-2

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3
Q

indicaciones generales de los AINES

A

dolor agudo, inflamacion, fiebre y antiagregacion (AAS)
dolor nociceptivo, inflamatorio, mixto (tx multimodal)

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4
Q

donde se encuentra COX-1

A

en todas las celulas

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5
Q

donde se encuentra COX-2

A

tejido inflamado

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6
Q

AINES con selectividad COX-2

A

diclofenaco. meloxicam, celecoxib

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7
Q

efectos adversos de AINES

A

gastritis, ulceras, sangrado de tubo digestivo, insuficiencia renal, aumenta riesgo cardiovascular

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8
Q

que AINE se asocia con el Sx de Reye

A

aspirina

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9
Q

AINE con mayor riesgo cardiovascular

A

naproxeno

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10
Q

mecanismo de accion del paracetamol

A

inhibidor de COX -3 en SNC

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11
Q

indicaciones de paracetamol

A

dolor leve moderado, sin act inflamatoria

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12
Q

efectos adversos de paracetamol

A

antiagregante
produce hepatotoxicidad por agotamiento de glutation

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13
Q

mecanismo de accion de gabapentinoides

A

antagonista de canales Ca, relacionados con GABA

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14
Q

indicaciones generales da gabapentinoides

A

dolor neuropatico, fibromialgia, convulsiones parciales, trastorno de ansiedad generalizada

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15
Q

efectos secundarios a gabapentinoides

A

fatiga, nausea, mareo, nistagmo, edema

categoria C - evitar si es posible

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16
Q

farmacos opioides

A

Morfina, codeína, oxicodona, hidromorfona, buprenorfina, nalbufina, fentanilo, sufentanilo, remifentanilo, metadona, tapentadol, tramadol.

17
Q

mecanismo de accion de opioides

A

agonistas de receptores opioides, preferente mu y kappa

18
Q

indicaciones generales de opioides

A

dolor moderado-severo
dolor posquirurgico
dolor neuropatico y oncologico

opioide seleccionados - diarrea y tos

19
Q

efectos secundarios por opioides

A

fentanilo - rigidez muscular en torax

20
Q

mecanismo de accion de tramadol

A

agonista debil de receptores mu, inhibidor de recaptura de NE y 5HT

21
Q

indicaciones generales de tramadol

A

dolor moderado - severo

22
Q

efectos colaterales de tramadol

A

cefalea, somnolencia, sudoracion, nausas, fatiga

clasificacion D

FARMACOLOGÍA (9 decks)

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