Anaesthetics Flashcards
Examples of neuromuscular junction blocking agents
Suxamethonium
Atracurium
Recuronium
Vecuronium
NMJ Blocker mechanism
Compete with acetylcholine at the NMJ
NMJ blocker cautions
Hypersensitivity
Myasthenia gravis
Neuromuscular disorders
Fluid/electrolyte disturbance
Side effects of NMJ blockers
Histamine Release- flushing, hypotension, tachycardia, bronchospasm
Atracurium dose and route
IV 300-600 micrograms per kg
Then 100-200 micrograms per kg as required
Suxamethonium dose and route
1-1.5 mg/kg IV
How is a NMJ blockade reversed?
Acetycholinesterase inhibitors-neostigmine.
What is propofol used for?
Induction
Maintenance in total intravenous anaesthesia
Propofol side effects
Pain on injection Hypotension Tachycardia Apnoea Headache Convulsions Anaphylaxis
What is thiopental sodium?
Barbiturate
Used for induction
Thiopental sodium side effects
Cvs and respiratory depression
Sedation for up to 24 hours
What is etomidate?
I V agent
Sedative hypnotic agent
Safer cvs profile
Side effects of etomidate
Corticosteroid production suppression
What is ketamine?
Anaesthetic
Less suppression of breathing
Ketamine adverse effects
Hallucination