Anaesthesia - Injectable pharmacology

Question 1

Propofol

Answer 1

GABA effects - anxiolytic
Rapid onset
5-10 min duration
Liver metabolised
Inc. plasma protein and lipid soluble
Hypotension, myocardial depression and VD
Post induction apnoea common - muscles and ST in throat relax
Cats = heinz body anaemia

Question 2

Alfaxalone

Answer 2

Neutrogenic steroid
Clear solution
High TI, 20% plasma protein bound
Quick onset, elimination and metabolism (liver)
15-30 min duration
Resp depression, preserve BR tone -> HR inc in response to dec. BP

Question 3

Ketamine

Answer 3

Duration: 20-40 min
Dose dependent
Liber metabolised
Dissociative anaesthesia - NMDA antagonist, poor muscle relaxation not used alone
Reflex maintained
Symp stimulation
Slow onset
Mantains CV/ resp
Horses
TIVA

Question 4

Tiletamine/zolaxepam

Answer 4

IM/IV repeated dose (poor recovery), Dogs and Cats, X rabbits

Question 5

Thiopental

Answer 5

Barbiturate
Rapid onset
Powder made up to 2-2.5%
Alkaline
Perivascular tissue necrosis - make sure secure IV access
Moderate CR depression - ventricular (abnormal heart rhythm)
Redistribution metabolism
80% Plasma protein bound