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Leukemia of the myeloid Lineage > AML t/inv (16;16) > Flashcards

AML t/inv (16;16) Flashcards

1
Q

Whats another name for (16;16)

A

Acute monomyelocytic leukemia

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2
Q

What is the result of this translocation or inversion>

A

CBFB- MyH11 Inhibits myeloid differentiation so class II

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3
Q

Who is normally affected?

A

Kids and adults

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4
Q

What are the major phenotypic markers?

A

CD34- blasts
CD 13, CD 33- granulocyte
CD 14, CD 11b- monocyte

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5
Q

What is the morphology?

A

Mixed granulocyte/ monocyte features

Easionphillia

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6
Q

Prognosis?

A

Poor

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7
Q

Treat?

A

ARA-C, Daunorubicin, maybe thioguanine

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Leukemia of the myeloid Lineage (14 decks)

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