AML t(8;21) Flashcards
1
Q
What is the Gilliand Hypothesis?
A
That there are two ways a translocation can cause malignancy, Class 1) Unregulated proliferation, Class 2) Inhibit differentiation by binding to DNA as a co-repressor and inhibit transcription.
2
Q
What class of translocation is t(8;21)?
A
Class II- Inhibits differentiation
3
Q
What is the gene product of the t(8;21)
A
ETO-AML1
4
Q
What age group is mostly affected by the AML t(8;21)?
A
Young adults and kids
5
Q
What is the clinical presesntation of t(8;21)?
A
fatigue, bleeding, infection
6
Q
Prognosis?
A
Good response to Chemo
7
Q
What morphological feature should stand out?
A
AUER RODS
8
Q
Immunophenotypes present
A
CD34, CD33, CD13
