AML t(15;17)

Question 1

What is the result of the t(15;17)?

Answer 1

PML-RARA…Inhibits granulocyte differentiation (class II)

Question 2

What is another name for t(15;17)

Answer 2

Acute Promyelocytic Anemia

Question 3

What do t(15;17) patients present with?

Answer 3

DIC, thrombocytopenia, and Leukocytosis

Question 4

What is the prognosis?

Answer 4

If caught early, 90% reach complete remission

Question 5

DON”T MISS t(15;17)

Answer 5

SERIOUSLY, DONT FUCKING MISS IT.

Question 6

How do you treat adults?

Answer 6

ATRA and Arsenic

Question 7

How do you treat children?

Answer 7

ATRA, anthracycline, cytarabine

Question 8

Morphology of t(15;17)?

Answer 8

Auer rods, Heart shaped nuclei