Acute Myeloblastic Leukemia with Normal Cyto

Question 1

Name the 4 types of Acute Myeloblastic Leukemias that we need to know

Answer 1

AML with normal cytogenetics
AML t(8;21)
Acute Promyelocytic t(15;17)
Acute Myelomonocytic (t/inv (16;16)

Question 2

AML with Normal Cyto: Who does it usually affect?

Answer 2

Any age though pediatric pts are uncommon.

Question 3

What percent of AML cases do AML with Normal cyto make up?

Answer 3

40-50%

Question 4

What does AML with Normal prognosis depend on?

Answer 4

genetics

Question 5

AML with normal: What gene combination doesn’t react to bone marrow transplant?

Answer 5

NPMN1 or CEBPA+, FLT3-ITD-

Question 6

AML with normal: What gene combo lends itself well to bone marrow transplant

Answer 6

FLT3-ITD+ or NPMN1-, CEBPA-, FLT3-ITD-

Question 7

Markers for AML with Normal

Answer 7

CD34+ , Lineage specific markers

Question 8

AML with Normal: Treatment outline?

Answer 8

Treat if under 60 and no co-morbidity.

Drugs used: Daunorubicine, Cytarbine, maybe Thioguanine