aminosalicyclates Flashcards
1
Q
name two aminosalicylclates
A
mesalazine
sulfasalazine
2
Q
what are they used for
A
UC and RA respectively
3
Q
MOA
A
works by acting as a coat to gut lining in UC
releae 5ASA
anti inflammatory and immunosuppressive effects
4
Q
why is sulfasalazine not used in UC
A
side effects
5
Q
SE
A
gi upset- nausea, dypsepisa headache trhombycyptopenia and leucyctopena renal impairment olgiospermia fever, rash -hypersensitivity reaction
6
Q
who should not use this
A
those with aspirin hypersensitivity
7
Q
drug interactions
A
mes- with PPIs
latulose lowers stool PH so may prevent 5ASA release n colon
