Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Adv Pharm > Aminoglycosides > Flashcards

Aminoglycosides Flashcards

1
Q

examples

A

streptomycin

kanamycin

gentamycin

amikacin

neomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

mech of action

A

bactericidal by acting on intracellular protein synthesis

NO NOT ACT OF CELL WALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

use

A

aerobic gram neg. bacteria

gentamycin broader spectrum, toxic levels if > 9mcg/ml

neomycin adjunct therapy to hepatic coma (lowers NH3 with given PO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

met/elim

A

extensive renal excretion

T1/2 - 2-3 hr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

side effects

A

ototoxicity - dose dependent, irreversable

nephrotoxicity (tubular necrosis, reversable

skeletal muscle weakness (decreased release of ACh and decreased sensitivity post synaptically)

prolongs NMB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

anesthesia considerations

A

1st sign of nephro-toxicity is inability to concentrate urine

caution in myasthenia gravis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Adv Pharm (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions