Cephalosporins Flashcards
1
Q
examples
A
1st gen - cefazolin
2nd gen - cefoxitin
3rd gen - cefotaxime
2
Q
mech of action
A
bactericidal
inhibits cell wall synthesis
increased generation - broader spectrum
3
Q
use
A
broad spectrum
often used in ortho surgery
1st gen - gram - only, cheapest
4
Q
met/elim
A
renal excretion but 40% excreted in bile
5
Q
side effects
A
allergic reactions
rash, anaphylaxis
6
Q
anesthesia considerations
A
may give slow test dose if allergic to PCN
