Aminoacidos Flashcards

1
Q

clasificacion de los NT aminoácidos

A
  • Exitatorios
  • Inhibitorios
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2
Q

Aminoacidos excitatorios

A
  • Glutamato
  • Aspartato
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3
Q

Aminoacidos inhibitorios

A
  • GABA
  • Glicina
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4
Q

vias de síntesis del glutamato

A
  1. α-cetoglutarato
  2. Glutamina
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5
Q

como se forma glutamato a partir de la glutamina

A

enzima glutaminasa

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6
Q

como se forma glutamato a partir de la α-cetoglutarato

A

enzima GABA-transaminasa

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7
Q

tipos de receptores del glutamato

A
  • Ionotrópicos
  • Metabotrópicos
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8
Q

receptores ionotropicos del glutamato

A
  • AMPA
  • Kainato
  • NMDA
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9
Q

receptores metabotropicos del glutamato

A
  • mGluR 1-7
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10
Q

como se activan los receptores NMDA del glutamato

A
  1. Se une a él también la glicina para que se abra
  2. Esta bloqueado por Mg
  3. Se libera cuando la cell se despolariza un poco con ayuda de los otros receptores ionotrópicos del glutamato
  4. Deja pasar Ca+ y Na+
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11
Q

diferencia entre los receptores ionotrópicos del glutamato

A
  • PEPS del receptor NMDA es más lento que el de AMPA
  • Kainato pero puede ser excitotóxico porque deja pasar mucho Ca
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12
Q

Característica principal de GABA

A

Principal neurotransmisor inhibitorio del SNC

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13
Q

cómo se forma GABA

A
  • descarboxilación de glutamato por enzima glutamato descarboxilasa (GAD)
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14
Q

tipos de receptores de GABA

A
  • Ionotrópicos
  • Metabotrópicos
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15
Q

receptor ionotrópico de GABA

A

GABA (A)

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16
Q

receptor metabotrópico de GABA

A

GABA (B)