AM L6 Hepatitis Flashcards
Functions of the liver (5)
Synth bile salts Secrete bicarb Clotting factors Synth plasma proteins Metabolism (including chol)
Types of Hep (7)
Alcoholic Viral Drug induced Metabolic Obstructive Autoimmune Ischemic
Hep C is transmitted by
Blood
Hep V causes ….% of liver cancer
60%
60% of Hep C is transmitted via
IV drug use
Incubation period of Hep C
15-150days
….% of patients with chronic hep C get cirrhosis
80%
Hep C has few symtoms: (2)
malaise or fatigue
jaundice
HCV is composed of
single stranded RNA
in a nucleocapsid
in an envelope
How does HCV attach? (3)
Claudin 1
Scavenger B1
CB81
After HCV attachment what happens? (4)
Engulfment
Replication
Viral assembly
Budding
Viral gylcopeptides on the envelope that are essential for entry of HCV (2)
E1 and E2
2 Drugs used for HCV
Pegylated interferon
Ribavirin
Ribavirin is a ….
oral neucloside
Peginterferon works by
anti-viral
anti-proliferative
immune modualtion
How do NRRI work?
Forced stop nucleotide which ends RNA replication
First NRRI in clinical trials?
Valopicitabine
Can we use NRRI with
Pegylated interferon
OR Ribavirin
Peg-IFN -Yes
Ribavirin - No (antagonised the antiviral effects)
NNRRI interact with
NRRI catalytic sight (at a number or allosteric sites)
NNRRIs may be (3) types
RNA aptamers
Small molecule inhibitors
Peptidomimetic inhibitors
e.g. of NNRRI….
and can it be used with PEGinterferon and ribavirin?
Telaprevir
Yes
Hep A is transmitted by
contaminated food and water
Main ways to combat hep A (2)
better sanitation and vaccines
Hep E is transmitted
faecal-orally
waterborne disease