alzheimers drugs Flashcards
reversible ACh inhibitor
treat AD
irreversible ACh inhibitor
used in biochemical warfare
treatment for mild-moderate AD
acetylcholine esterase inhibitor
Ach dependent parasympathomimetic effects
Bradycardia
bronchoconstriction
gastric acid secretion
intestinal motility
benefits of donepezil
Once daily
rapidly enters brain
80-100% bioavailability
donepezil adverse effects
drug-drug interactions with muscarinic receptor blockers
transient diarrhea, nausea, vomiting
precautions with donepezil
precautions with respiratory conditions and cardiovascular conditions
peripheral effects of donepezil
gastric acid secretion
intestinal motility
emesis
diarrhea
why does donepezil cause vomiting
ACh muscarinic receptor activation in the area postrema
cardiac effects of donezepil
reduces rate, automaticity, contractility, refractory period and conduction velocity
vascular effect of donepezil
indirectly vasodilator
half-life of galantamine
7 hours
where is galantamine metabolized
liver
adverse effects of galantamine
drug-drug interactions with anti-cholinergic drugs
some nausea and vomiting
precautions with galantamine
precautions in those with cardiovascular problems and GI problems
benefits of rivastigmine
transdermal patch
useful in parkinsons
metabolism of rivastigmine
hepatic
which Alzheimers drug is effective in parkinsons disease
rivastigmine
adverse effects of rivastigmine
drug drug interactions with anticholinergics and beta blockers
precautions with rivastigmine
precaution in those with GI problems and those with allergic dermatitis
why is rivastigmine cautioned with beta blockers
both reduce the work of the heart
MOA of memantine
NMDA antagonist
