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Neuro/psych exam 2 > alzheimers drugs > Flashcards

alzheimers drugs Flashcards

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1
Q

reversible ACh inhibitor

A

treat AD

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2
Q

irreversible ACh inhibitor

A

used in biochemical warfare

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3
Q

treatment for mild-moderate AD

A

acetylcholine esterase inhibitor

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4
Q

Ach dependent parasympathomimetic effects

A

Bradycardia
bronchoconstriction
gastric acid secretion
intestinal motility

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5
Q

benefits of donepezil

A

Once daily
rapidly enters brain
80-100% bioavailability

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6
Q

donepezil adverse effects

A

drug-drug interactions with muscarinic receptor blockers
transient diarrhea, nausea, vomiting

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7
Q

precautions with donepezil

A

precautions with respiratory conditions and cardiovascular conditions

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8
Q

peripheral effects of donepezil

A

gastric acid secretion
intestinal motility
emesis
diarrhea

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9
Q

why does donepezil cause vomiting

A

ACh muscarinic receptor activation in the area postrema

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10
Q

cardiac effects of donezepil

A

reduces rate, automaticity, contractility, refractory period and conduction velocity

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11
Q

vascular effect of donepezil

A

indirectly vasodilator

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12
Q

half-life of galantamine

A

7 hours

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13
Q

where is galantamine metabolized

A

liver

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14
Q

adverse effects of galantamine

A

drug-drug interactions with anti-cholinergic drugs
some nausea and vomiting

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15
Q

precautions with galantamine

A

precautions in those with cardiovascular problems and GI problems

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16
Q

benefits of rivastigmine

A

transdermal patch
useful in parkinsons

17
Q

metabolism of rivastigmine

A

hepatic

18
Q

which Alzheimers drug is effective in parkinsons disease

A

rivastigmine

19
Q

adverse effects of rivastigmine

A

drug drug interactions with anticholinergics and beta blockers

20
Q

precautions with rivastigmine

A

precaution in those with GI problems and those with allergic dermatitis

21
Q

why is rivastigmine cautioned with beta blockers

A

both reduce the work of the heart

22
Q

MOA of memantine

A

NMDA antagonist

Neuro/psych exam 2 (11 decks)

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