alosetron Flashcards
what is the classification of alosetron
Selective 5-HT3 receptor antagonist (anti-IBS)
what is the trade name for alosetron
Lotronex
what is the pharmacotherapeutics for alosetron
treatment of IBSl used in severe cases only
how is alosetron administered
orally
what is the pharmacodynamics of alosetron
- blocks the 5-HT3 receptor
- alters visceral sensation, decreasing abdominal discomfort and pain
- lengthens transit time in bowel and decreases water and chloride secretions which help control diarrhea
what are the C/I and precautions of alosetron
Hx of chronic constipation, obstruction, GI megacolon, perforation, adhesions, Crohn’s Dx
what are the A/E of alosetron
constipation
what are the D/I of alosetron
no important drug interatctions w/alosetron have been identified
what health status would you assess with pts taking alosetron
- assess type of IBS
what life span and gender would you assess with pts taking alosetron
pregnancy category B
how would you maximize the therapeutic effects of alosetron
no specific actions are recommended
how would you minimize the A/E of alosetron
- confirm that the pt has received the medication guide from the prescriber before starting therapy and has read it and understand it
- answers questions about therapy
what are the patient and family education of alosetron
- educate the pts about the potential A/E
- instruct pts to report any constipation or signs of ischemic colitis
what are the ongoing assessment and evaluation of alosetron
assess the pt throughout alosetron therapy for constipation
