Allergy Flashcards
what causes type 1 hypersensitivity?
drugs
how soon does type 1 hypersensitivity occur?
after 2nd contact with an antigen
why isn’t there a rxn after the 1st exposure to antigen?
body has to mount some type of response first
what type of rxn is type 1 hypersensitivity?
igE mediated rxn
what happens in an igE-mediated rxn?
- release of chemical mediators
- release of histamine, leukotrienes, interleukins
- vascular dilation and endothelial leakage
syms of type hypersensitivity
- hay fever
- asthma
- urticaria
- angioedema
- anaphylaxis
signs and syms of TRUE allergic rxn
- urticaria
- swelling
- skin rash
- chest tightness
- dyspnea, SOB
- rhinorrhea
- conjuctivitis
are heart palpitations a sym of a true allergic rxn?
no
why do ppl think they’re allergic to hydrocodone?
says hydrocodone makes them feel sick to stomach but opioid receptors in stomach do that
urticaria
superficial skin lesion
txtment for urticaria
50 mg diphenhydramine 4x/day until swelling resolves
angioedema
- edema in deeper planes
- diffuse enlargement of lips, infraorbital tissues, larynx, tongue
txtment for angioedema
send to ER so they can get through their acute phase
anaphylaxis
acute rxn occurs within minutes of injection, ingestion, or application of drugs
is anaphylaxis fatal?
yes, can be fatal within minutes without immediate, aggressive txtment
