allergy

Question 1

indicationsBC treatments for specialized

Answer 1

irradiated: bone marrow transplant, acuired or congenital cellular immunodeficiency , blood components donated bt first or second degree relatives

leuoreduced: chronically transfused patients, CMV for high risk patients, potential transplant recipients, previous febrile nonhemolytic transfusion reaction

washed,; IGa def, complement dependent autoimmune hemolytic anemia, continued allergic reaction( hives) with red cell transfusion despite antihistamine treatment

Question 2

B cell disorders

Answer 2

age more than 6 monthes

encapsulated bacteria, entrovirus only ( x linked agammaglobulinemia)

low Ig and vaccine response,

common variable and X linked gama…

Question 3

t cll ( combined B and T )

Answer 3

early under 4-6 months,
viral , bacterial and fungal, ( candida and PCP) , failure to thrive
leuocyte is low and +- low Ig and vaccine response
digeorge (only T), severe combined immunodeficiency , wiskott- aldrich synd, ataxia telangectasis

Question 4

phagocyte

Answer 4

childhood

skin and soft tissueinf, funga, catalase positive, (s aureus, burkholderia, serratia, nocardia, aspergillus)
normal IG , impaired oxidative burst

DHR flowcutometry < NBT test ,

prophylaxis: cotri, itra, interferon gamma, cell transplant (curative)
chronic granulomatous disease(X linked), leukocyte adhesion defect

Question 5

complement disorder

Answer 5

variable,
nisseria and autoimmune,
CH50 low, and normal Ig and leukocyte,

C1 def and terminal complement def