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Pediatrics > Allergy > Flashcards

Allergy Flashcards

1
Q

content of an allergen which promote barrier dysfunction and increase allergen penetration

A

protease

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2
Q

Th2 cells secrete cytokine favoring IgE synthesis and eosinophilia such as

A

IL-4
IL-5
IL-13

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3
Q

IL-4 and IL-13 play a key role in?

A

immunoglobulin isotype switching to IgE

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4
Q

cytokines that are important in development and differentiation of eosinophils

A

IL-5

IL-9

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5
Q

contributes to mast cell activation

A

IL-3
IL-4
IL-9

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6
Q

cells that are typically involved in the eradication of intracellular organisms

A

Th1 cells

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7
Q

chronic lesions of allergic reactions are characterized by infiltration of

A

Th1 cells

Th17 cells

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8
Q

promotes tissue inflammation

A

Th1
Th2
Th17

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9
Q

subset of T cells that plays a critical role in expression of allergic and autoimmune diseases

A

T regulatory cells (Treg) cells

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10
Q

CD4*CD5 Treg cells expresses specifically

A

FOXP3

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11
Q

dendritic cells, langerhans cells, monocytes and macrophages

A

APC

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12
Q

dendritic cells and langerhans cells prime the näive T cells. what phase?

A

sensitization phase

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13
Q

monocytes and macrophages activate memory T cell responses. what pahse?

A

elicitation phase

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14
Q

myeloid DC or plasmacytoid DC

A

mature DCs

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15
Q

derived from CD34; travel to peripheral tissue and undergoes tissue-specific maturation

A

mast cells

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16
Q

widely distributed throughout the connective tissue, lie adjacent to blood vessels and beneath epithelial surface to automatically participate in allergic reactions

A

mast cells

17
Q

induce airway hyperresponsiveness

A

major basic protein

18
Q

common granule mediator for allergy

A

histamine

19
Q

bronchoconstriction and intestinal hypermotility is caused by what mediators of HSR

A

lipid mediators (PAF, PGD2 and LTC)

20
Q

the immediate response after allergen is introduced into target organs

A

early phase response

21
Q

rubbing the nose upward with the palm of their hand

A

allergic salute

22
Q

allergy that is more common in infant and young children

A

food allergies

23
Q

children receiving inhaled corticosteroids may experience?

A

growth suppression

24
Q

patients with acute asthma may experience a drop in systolic blood pressure during inspiration >10mmHg. this is called?

A

pulsus paradoxus

25
Q

most common skin abnormality of allergic children

A

xerosis

26
Q

found on facial cheeks and extensor surfaces of the upper arms and thighs, is a benign condition characterized by skin-colored or slightly pink papules caused by keratin plugs lodged in the openings of hair follicles

A

keratosis pilaris

27
Q

thickened skin in the palms or soles with exaggerated creases; seen in children with moderate to severe atopic dermatitis

A

palmar hyperlinearity

28
Q

licker’s dermatitis aka

A

cheilitis

29
Q

most common hematologic abnormality of allergic patients

A

eosinophilia (>500/uL)

30
Q

primary in vivo skin procedure for the diagnosis of allergy

A

allergen skin testing

31
Q

confirm the diagnosis of eosinophilic esophagitis

A

endoscopy

32
Q

major chronic respiratory disease of children (20-30%)

A

allergic rhinitis

33
Q

common target of allergic disorders because of its marked vascularity and direct contact with allergens in the environment

A

eye

34
Q

most immunologically active tissue of the external eye

A

conjunctiva

35
Q

most common hypersensitivity response of the eye

A

allergic conjunctivitis

36
Q

in ocular allergy, sensitization is necessary except

A

giant papillary conjunctivitis

37
Q

is a CHRONIC inflammatory ocular disorder most commonly involving the lower tarsal conjunctiva; it may threaten eyesight if there is corneal involvement

A

atopic keratoconjunctivits

Pediatrics (8 decks)

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