Allergy

Question 1

content of an allergen which promote barrier dysfunction and increase allergen penetration

Answer 1

protease

Question 2

Th2 cells secrete cytokine favoring IgE synthesis and eosinophilia such as

Answer 2

IL-4
IL-5
IL-13

Question 3

IL-4 and IL-13 play a key role in?

Answer 3

immunoglobulin isotype switching to IgE

Question 4

cytokines that are important in development and differentiation of eosinophils

Answer 4

IL-5

IL-9

Question 5

contributes to mast cell activation

Answer 5

IL-3
IL-4
IL-9

Question 6

cells that are typically involved in the eradication of intracellular organisms

Answer 6

Th1 cells

Question 7

chronic lesions of allergic reactions are characterized by infiltration of

Answer 7

Th1 cells

Th17 cells

Question 8

promotes tissue inflammation

Answer 8

Th1
Th2
Th17

Question 9

subset of T cells that plays a critical role in expression of allergic and autoimmune diseases

Answer 9

T regulatory cells (Treg) cells

Question 10

CD4*CD5 Treg cells expresses specifically

Answer 10

FOXP3

Question 11

dendritic cells, langerhans cells, monocytes and macrophages

Answer 11

APC

Question 12

dendritic cells and langerhans cells prime the näive T cells. what phase?

Answer 12

sensitization phase

Question 13

monocytes and macrophages activate memory T cell responses. what pahse?

Answer 13

elicitation phase

Question 14

myeloid DC or plasmacytoid DC

Answer 14

mature DCs

Question 15

derived from CD34; travel to peripheral tissue and undergoes tissue-specific maturation

Answer 15

mast cells

Question 16

widely distributed throughout the connective tissue, lie adjacent to blood vessels and beneath epithelial surface to automatically participate in allergic reactions

Answer 16

mast cells

Question 17

induce airway hyperresponsiveness

Answer 17

major basic protein

Question 18

common granule mediator for allergy

Answer 18

histamine

Question 19

bronchoconstriction and intestinal hypermotility is caused by what mediators of HSR

Answer 19

lipid mediators (PAF, PGD2 and LTC)

Question 20

the immediate response after allergen is introduced into target organs

Answer 20

early phase response

Question 21

rubbing the nose upward with the palm of their hand

Answer 21

allergic salute

Question 22

allergy that is more common in infant and young children

Answer 22

food allergies

Question 23

children receiving inhaled corticosteroids may experience?

Answer 23

growth suppression

Question 24

patients with acute asthma may experience a drop in systolic blood pressure during inspiration >10mmHg. this is called?

Answer 24

pulsus paradoxus

Question 25

most common skin abnormality of allergic children

Answer 25

xerosis

Question 26

found on facial cheeks and extensor surfaces of the upper arms and thighs, is a benign condition characterized by skin-colored or slightly pink papules caused by keratin plugs lodged in the openings of hair follicles

Answer 26

keratosis pilaris

Question 27

thickened skin in the palms or soles with exaggerated creases; seen in children with moderate to severe atopic dermatitis

Answer 27

palmar hyperlinearity

Question 28

licker's dermatitis aka

Answer 28

cheilitis

Question 29

most common hematologic abnormality of allergic patients

Answer 29

eosinophilia (>500/uL)

Question 30

primary in vivo skin procedure for the diagnosis of allergy

Answer 30

allergen skin testing

Question 31

confirm the diagnosis of eosinophilic esophagitis

Answer 31

endoscopy

Question 32

major chronic respiratory disease of children (20-30%)

Answer 32

allergic rhinitis

Question 33

common target of allergic disorders because of its marked vascularity and direct contact with allergens in the environment

Answer 33

eye

Question 34

most immunologically active tissue of the external eye

Answer 34

conjunctiva

Question 35

most common hypersensitivity response of the eye

Answer 35

allergic conjunctivitis

Question 36

in ocular allergy, sensitization is necessary except

Answer 36

giant papillary conjunctivitis

Question 37

is a CHRONIC inflammatory ocular disorder most commonly involving the lower tarsal conjunctiva; it may threaten eyesight if there is corneal involvement

Answer 37

atopic keratoconjunctivits