Allergies

Question 1

Whats a type I reaction in the Gells and Coombs classification?

Answer 1

-IgE, acute anaphylaxis (hypersensitity and parasite resistance)
-Immunological memory
eg hay fever asthama
-mast cell mediator - histamine
-diagnosis - SPTs, RAST

*treatment* 
avoid exposure
antihistamines
bronchodilators
steroids

Question 2

Whats a type II reaction in the Gells and Coombs classification?

Answer 2

-IgG or IgM bound against antigen on an individual’s own cells, or against foreign antibody, such as that acquired after blood transfusion.
eg good pasture’s syndrome (autoimmune disease)
after wrong blood transfusion

Question 3

Whats a type III reaction in the Gells and Coombs classification?

Answer 3

Immune complexes (antigen and usually IgG or IgM) are deposited in the tissue.

• causes local tissue damage and inflammation
  eg. farmers lung

Question 4

Whats a type IV reaction in the Gells and Coombs classification?

Answer 4

-Slow formation of granulomas, activates T cells
eg. Crohn’s disease
Leprosy
Tuberculosis

Question 5

What can cause chronic inflammation?

Answer 5

• structural abnormalities (eg bronchiectasis)
• inappropriate cellular response (Rh arthritis) (autoimmune)
• Initiating causes persists (eg gall stones)

Question 6

Name 3 types of antibodies and what they do

Answer 6

IgM - beginning of infection
IgG - highly specific targeting specific ‘epitopes’
IgE - made to things that we are allergic to