Allergic Eye Disease Flashcards
Name the 4 types of hypersensitivity reaction?
IgE mediated, cytotoxic, immune complex, delayed hypersensitivity
Which types of hypersensitivity reaction are most important when it comes to allergic eye disease?
IgE mediated, delayed hypersensitivity
Name the subtypes of ocular allergy?
Acute ocular allergy, seasonal/perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopid keratoconjunctivits and Contact lens Associated Papillary Conjunctivitis
Describe an acute ocular allergy reaction?
Sudden onset, watery discharge, itching, unilateral occasionally, sudden lid swelling
Describe season/perennial ocular allergy?
Intense itching and hyperaemia, excessive watering, lid swelling, associated rhinitis, papillae
Describe vernal keratoconjunctivitis?
Occurs in first decade, mucoid stringy discharge and watering, severe itch with asymmetrical symptoms, seasonal exacerbation.
Describe atopic keratoconjunctivitis?
Occurs between 20s and 50s, mucoid stringy white discharge, severe bilateral itching and burning, year round but does have seasonal exacerbations.
What is the drug action of mast cell stabilizers and name pros and cons?
They prevent mast cells from degranulating and releasing more histamine, they are very effective at does this, but they have a long delay and do nothing about histamine that is already released.
Name two mast cell stabilizers.
Sodium cromoglicate, lodoxamide.
Name the two classes of anti-histamine drugs?
Sedating and non-sedating.
Name one sedating anti-histamine.
Chlorphenamine.
Name one non-sedating anti-histamine.
Citirizine, acrivastine.
Name on benefit of lodoxamide over sodium cromoglicate, and one negative.
Lodoxamide has much better absorption but it also has many more possible side effects.
