All meds MoA

Question 1

Proton pump inhibitor

Answer 1

decrease acid secretions by binding to H+,K-ATPase enzyme

Question 2

h2 receptor antagonist

Answer 2

block h2 receptors in parietal cells to decrease acid production in daytime and nocturnal

Question 3

antacids

Answer 3

react with gastric acids to produce neutral salt, alter systemic pH, EXCEPT FOR BICARBONATE

Question 4

bismuth compounds

Answer 4

stimulate mucosal bicarbonate and prostaglandin production, inhibit h.pylori from adhering to tissue

Question 5

sucralfate

Answer 5

stimulate mucus, bicarbonate and prostaglandin secretion, coat stomach to form barrier

Question 6

1st gen receptor antagonist

Answer 6

block main histamine receptors

Question 7

2nd gen h1 receptor agonist

Answer 7

compete with histamine for h1 receptor in peripheral

Question 8

intranasal corticosteroid

Answer 8

inhibit mast cells, microphages and inflamm mediators, vasoconstriction

Question 9

pseudoephedrine

Answer 9

activate alpha-adrenergic receptors, cause vasoconstriction in nasal mucosa

Question 10

nonopioid antitussive

Answer 10

act on cough center in medulla

Question 11

guaifenesin

Answer 11

(expectorant) irritate respiratory tract, loosen and thin secretion

Question 12

acetylcystine

Answer 12

(mucolytic) breakdown proteins in mucus to make thinner

Question 13

beta2 adrenergic agonist

Answer 13

bind to beta2 adrenergic receptors in bronchial smooth muscle to cause bronchodilation

Question 14

anticholinergic

Answer 14

block cholinergic receptors in bronchial smooth muscle, decrease nasal hypersecretion

Question 15

corticosteroid

Answer 15

decrease inflammatory and immune response

Question 16

leukotrine modifier

Answer 16

block leukotrine receptors in airways to prevent airway edema and inflammation

Question 17

mucolytics

Answer 17

loosen bronchial secretions

Question 18

expectorants

Answer 18

aid in removal of mucus

Question 19

sulfonylureas

Answer 19

stimulate release of insulin from pancrease, increase cell sensivity to insulin

Question 20

buganide (metformin)

Answer 20

decrease hepatic production of glucose, decrease intestinal reabsorption of glucose, increase cell uptake of glucose

Question 21

meglitinides

Answer 21

stimulate release of insulin from pancrease, decrease post pradinal glucose levels and A1C (not fasting glucose)

Question 22

thiazolidinediones

Answer 22

increase cell sensitivity to insul, decrease hepatic production of glucose (lowering take 3-4mo)

Question 23

incretin

Answer 23

increase insulin secretion, decrease glucagon secretion, delayed gastric emptying (increase in satiety)

Question 24

alpha glucosidase inhibitor

Answer 24

block enzyme in SI that breakdown complex carbs

Question 25

sodium-glucose cotransporter

Answer 25

inhibit sodium-glucose cotransporters in kidney, glucose lost in urine

Question 26

cathartic laxitive

Answer 26

immediate relief

Question 27

prophylaxis

Answer 27

when don’t want straining

Question 28

psyllium

Answer 28

similar to dietary fiber, swell with water into firm gel

Question 29

laxitive salts

Answer 29

draw water into lumen of LI, fecal mass softens, swells, wall streches to stimulate peristalsis

Question 30

biscodyl

Answer 30

stimulate intestinal motility, increase amounts of water and electrolytes in intestinal lumen

Question 31

docusate

Answer 31

additional water and lipids penetrate stool

Question 32

diphenoxylate with atropine

Answer 32

acts on smooth muscle of SI to slow peristalsis

Question 33

loperamide

Answer 33

first line drug for chronic diarrhea maintenance

Question 34

bismuth subsalcylate

Answer 34

(pepto bismol) indigestion, heartburn, diarrhea

Question 35

anticholinergic and antihistamine (n/v)

Answer 35

simple nausea ex/motion sickness

Question 36

serotonin receptor antagonist

Answer 36

chemo n/v

Question 37

dopamine antagonist

Answer 37

normal n/v

Question 38

corticostroids (n/v)

Answer 38

chemo and post op n/v