Alcoholism Flashcards
Type I
gradual
Type II
early onset
Lab values for alcoholic
MCV
High GGT
High AST / ALT
High uric acid
High TG
EtG and Ets
Ethanol ____ GABA
stimulates
Ethanol ____ NMDA
inhibits
Ethanol ___ dopamine
increases
Ethanol ___ opioid peptide
activates
Alcohol is a ___
depressants
Chronic use of alcohol effects GABA receptor by __
down regulation
abruptly quitting means less inhibitory NT
Chronic use of alcohol effects NMDA receptor by __
up regulation
abruptly quitting means more stimulation
Alcohol messes with ____ parts of brain first
most complex
Chronic alcohol use can cause
Addiction
Wernicke-Korsakoff
Cortical atrophy / Dementia
Hepatic
Pancreatic
Wernicke-Korsakoff syndrome caused by
Wernicke’s encephalopathy
Signs of Korsakoff
anterograde amnesia, hallucinations
PK of ethanol
lipid and water soluble
non protein bound
first order absorption
zero order elimination
capacity limited metabolism
gastric emptying increases absorption
Delirium tremens
disordered consciousness
last 1-5 days
mortality risk
hallucinations, disorientation, tachy
Treatment for ethanol withdrawal
Thiamine 50-100mg daily
D5 and 1/2 NS
multivitamin
Standing clonidine and benzo
Types of regimens for alcohol withdrawal
symptom triggered - Diazepam/Lorazepam q1 hr
fixed schedule - diazepam/lorazepam q 6hrs
Therapy in abstinence
Disulfiram
Naltrexone
Acamprosate
Disulfiram MOA
blocks aldehyde dehydrogenase cause buildup of acetyl CoA when drink
Naltrexone MOA
competitive antag at opioid receptor
Acamprosate MOA
inc. activity of GABA and dec, glutamate (mimics alcohol effects)
