alcoholic ketoacidosis

Question 1

definition

Answer 1

metabolic complication of alcohol use and starvation characterised by ketonameia and a raised anion gap metabolic acidosis without significant hyperglycaemia

Question 2

pathophysiology

Answer 2

alcohol reduces gluconeogenesis and leads to reduced insulin secretion increased lipolysis impaired fatty acid oxidation and subsequent ketogenesis

Question 3

presentation

Answer 3

vomiting, abdominal pain, dehydration, reduced alertness or coma

Question 4

management

Answer 4

pabrinex and IV fluids

Question 5

pabrinex contains

Answer 5

vitamin C (ascorbic acid) 
vitamin B1 (thiamine)
Vitamin B2 (riboflavin)
vitamin B3 (nicotinamide)
vitamin B6 (pyridoxine)

Question 6

IV fluids used

Answer 6

dextrose