Alcohol Flashcards
Ethyl Alcohol structure is similar to?
CHO
Ethyl Alcohol metabolism is similar to?
Fat Metabolism
Ethyl Alcohol provides how many kcals/g?
7
Ethyl Alcohol’s absorption is ______ and transport is facilitated via what systemic pathway?
Fast Absorption
Transport > Circulatory System (water soluble)
What micronutrient can absorb alcohol?
Sodium
What are the two pathways for alcohol oxidation (metabolism)?
Alcohol Dehydrogenase Pathway (ADH)
Microsomal Ethanol Oxidizing System (MEOS)
The Alcohol Dehydrogenase Pathway (ADH) produces enzymes in the ______ & on a ______ basis?
Liver / Hourly Basis
The ADH pathway functions in the?
Cytoplasm
The ADH pathway requires?
NAD+
The ADH pathway has a _______ production capacity?
Fixed Hourly Production
The Microsomal Ethanol Oxidizing System (MEOS) produces more _____ as more _____ is absorbed?
Produces more enzymes the more ethanol is consumed
The MEOS pathway functions in the?
ER of the Mitochondria
The MEOS pathway requires what carriers?
FAD, FMN, Cytochrome P-450
(similar to ETS)
The MEOS oxidizes what concurrently?
NADPH
The MEOS is said to be a _____ system?
Trainable
When Alcohol is ingested it is treated as ____ and will do what to other glycolytic & oxidative pathways?
Treated as VIP > will shut down other metabolism pathways.
The initial product of ethanol oxidation is _____ & is _____ toxic than alcohol, therefore requiring fast conversion.
Acetaldehyde > more toxic than alcohol.
Too much acetaldehyde coming into contact with the liver will result in what?
Cirrhosis
Too much alcohol intake will result in _____ NADH : NAD+ ratios?
High Ratios
What mechanisms result in Fatty Liver from alcoholism?
Increased Fatty Acid Synthesis
Increased TG Synthesis
Alcoholism impairs what metabolic pathway?
GNG
Alcoholism results in vitamin A deficiency through what mechanism?
Retinol Dehydrogenase does not become activated
Alcohol Intake can increase what?
HDL-C
Alcohol Intake can decrease what?
Platelate Aggregation
