AKI Flashcards
What results from the kidneys not being able to filter blood normally?
Build up of waste, fluid and electrolyte imbalance
What occurs in the prerenal stage that results in reduced kidney function
Issue with perfusion of blood to the kidneys - reduced amount of blood going to the kidneys to be filtered so kidneys deprived of nutrients
What leads to reduce perfusion of blood to the kidneys?
-reduced cardiac output
- bleeding (internal/external)
- dehydration- hypovolemia
- burns
What are the intrarenal causes ?
Damage to the nephrons - reduced ability to filter blood, remove waste and ++ H2O and maintain electrolyte lvls
What can cause damage to the nephron?
-nephrotoxic drugs eg. NSAIDS
- infection
-injury
What occurs during the postrenal stage?
Blockage in urinary tract that prevents draining out of urinary system
What does a blockage in urinary tract result in ?
Increased pressure on the kidneys and build up of waste
What does a normal adult void per day
1-2l/day
What does urine consist of ?
Ions, urea, creatinine, H2O
What is creatinine ?
Waste product from muscle breakdown
How is creatinine filtered
Solely filtered from the blood via the glomerulus an is not re absorbed/secreted in the nephron
What does creatinine measurement tells us
Shows kidney filtering ability
What does an increased lvl of creatinine in the blood indicate ?
Reduced kidney function
What is the creatinine clearance lvl
Amount of blood kidneys make per min that is free of creatinine
Females- 85-123ml/min
Males- 95-140ml/min
What does GFR show?
How well the glomerulus is filtering