AKI Flashcards
1
Q
CKD
A
structural or functional kidney abnormalities that persist for >3months +/- decreased eGFR - most commonly manifests as persistent albuminuria
2
Q
AKI
A
abrupt decrease in kidney function which encompasses injury and impairment - mixed aetiology where sepsis, ischaemia and nephrotoxicity co-exist
3
Q
Quantifying AKI
A
- Increase in creatinine by >0.3 mg/dl within 48h OR
- Increase in creatinine to >1.5x baseline which has occurred within a week OR
- Urine volume <0.5ml/kg/hr for 6 hours
4
Q
Urea
A
Made in liver from protein breakdown
Removed by glomeruli filtration
5
Q
Creatinine
A
Produced from muscle - proportional to muscle mass
6
Q
Which amino acids are in creatinine
A
Glycine and arginine
7
Q
AKI risk factors
A
Age
Co-morbiditieis
Medications
8
Q
Post renal causes of AKI
A
ureteral obstruction (stones tumours etc) bladder outflow obstruction (neurogenic bladder, prostate cancer)
9
Q
Renal causes of AKI
A
Vasculitis
GN
ATN - ischaemic or nephrotoxic
10
Q
Pre-renal causes of AKI
A
Hypovolaemia Decreased CO Decreased plasma volume vascular occlusion. ACEi, NSAIDs
