AIDS, CANCER & ARTHRITIS Flashcards
Psychoneuroimmunology
The immune system is linked to our psychological systems
Immune System
Security system- if something gets in it gets identified and destroyed
- allergies
- infection
- cancer
- autoimmune disorders
Natural Immunity
- Fast and broad
- General attackers
Granulocytes: largest groups of cells. Includes neutrophils and macrophages. Which are the first to arrive on the site
-Macrophages: release cytokines that lead to inflammation, fever and promote wound healing
Natural Killer Cells
- Recognize cancer and viral infections
- Creating an alarm system
Specific Immunity
- Slow but specific
- Lymphocytes- specific receptor for specific pathogen/antigen
Hum moral Immunity
- Mediated by B (bacteria) lymphocytes
- protection against bacteria and neutralize toxins they produce
- prevent viral infections
Cell-Mediated Immunity
Cytotoxic TC cells response to specific antigens
- Helper T(TH) cells enhance functioning of the Tc, B cells and macrophages
- If your helper cells aren’t working thats really bad. If other cells aren’t working, not as big of a deal
Immunocompetence * know this
Immune functioning can be assessed by- count of lymphocytes in blood (also T,B,NK cells)
- Assessing the functioning of the cells
- Activation
- Proliferation
- Transformation
- Cytotoxicity of cells
Immunocompetence Summing it up
Viral/bacteria comes into our body to build their family
- Our body creates antibodies to fight and keep memory of them- why you only get chicken pox once
- dead virus/flu shot- if your body doesn’t response or you get sick this isnt good
- we want to see immune response and not get sick from dead virus
- wound repair also a sign if your immune system is working
Short vs Long Term Stressors
Short Term Stressors:
- fight/flight
- increase NK cells and granular lymphocytes
Long Term Stressors:
- cellular and humeral down regulation
- strong among elderly
Down Regulation
Intense –> Acute –> Chronic
- This is hard on your body
Stress and Immune Function
Pro inflammatory cytokine: lead to inflammation
- Decrease in TH helper cells with anticipatory stress- compromises immune functioning
- Effects of stress on immune system can be DELAYED. Exams
- Overal idea: stress lowers immune functioning and increases inflammation
- Depression- not good
- Social support: increases NK cell activity-good
AIDS
“acquired immune deficiency syndrome”
- spread through world travel
- low condom use
- non sterile techniques through drug users AND 3rd world countries
- Decrease in new infections among adults and children
HIV= the virus, you’re the carrier. Doesn’t mean you have AIDS but its dormant in your system
AIDS Mechanism
HIV (human immunodeficiency virus)
- Attacks helper T cells and macrophages
- time between HIV -AIDS is variable
- lack of symptoms but still contagious
AIDS symptoms
Early:
- swollen glands, mild flu
Progressive:
- skeletal bone pain, chronic diarrhea, blindness, wasting away
AIDS Therapy ** know this
HAART (highly active antiretroviral therapy)
- needs to be taken the same time every day religiously
- SES and housing can correlate with how well you do with this treatment