aging theories Flashcards
aging theories
combined
program
damage
Programmed theories
imply that aging follows a biological timetable
Damage or error theory
emphasize environmental assaults to living organisms
non programmed aging
theories based on evolutionary concepts where aging is
considered the result of an organism’s inability to better combat natural deteriorative processes
programmed aging
Result of biological mechanism or program that purposely causes or allows deterioration and death
The Theory of Aging and Oxidative Stress
*It refers to the functional loss that occurs due to the irreversible and progressive increase of molecular oxidative damage.
*Oxidative damage may be inadequately repaired or eliminated.
Factors Playing a Role in The Theory of Aging and Oxidative Stress
- Increase in the amount of oxidative stress with age
- Increase in the amount of free radical formation
- Decrease in antioxidant defenses
- Reduction in removal or repair of damaged molecules
The Mitochondrial Theory Of Aging
free radicals produced by mitochondrial activity damage cellular components, leading to aging.
Major chronic diseases in which free oxygen radicals play
a role in physiology and pathophysiology
*Cardiological diseases
*Neurological diseases
*Asthma
*Diabetes mellitus
*Rheumatoid arthritis
*Cancer
*Other diseases in old age
Somatic Mutation Theory
*It refers to the accumulation of mutation in the genetic material of somatic cells that occurs during cell division when the DNA nucleotides that carry their hereditary codes are mismatched or lost. results in a decrease in cellular function
genetic theory
It is the theory of aging that tries to explain the functioning of the aging process with the hereditary characteristics of the living thing.
*Longevity genes
are specific genes that help a person
live longer.
*Cell senescence
the process by which cells deteriorate over time.
Immune Mechanism Theory
It expresses the aging that occurs in parallel with the loss of performance and competence of the structures that make up the immune system with aging
antioxidants
*defense systems that detoxify free radicals in cells.
*It protects the organism against oxidative changes.
A high antioxidant defense system can slow down physiological damage and aging.