Ageing Process Flashcards
1
Q
Give some factors that affect human ageing
A
Random molecular damage during cell replication
Inactivity
Poor diet
Inflammation
2
Q
What is a telomere?
A
The end part of each chromosome arm
3
Q
What occurs to a telomere when cells replicate?
A
It shortens - leads to cell senescence
4
Q
What is the Hayflick limit?
A
The limit to the amount of times a cell can replicate
5
Q
What does telomerase do?
A
It re-extends shortened telomeres
6
Q
Give some causes of DNA mutation and damage
A
Ionising radiation
Reactive oxygen species
Extrinsic toxins
7
Q
What are the four main responses to cellular damage?
A
Repair
Apoptosis
Senescence
Malignancy
8
Q
What tools can measure frailty?
A
Deficit accumulation
Fried score
