Ageing Heart Flashcards
How does Calcium transients contribute to raise in mmHg?
allows for ca2+ influx
describe the journey of calcium within cardiac myocytes
- Ca enters the sarcolemma
- Ca binds to sarcoplasmic reticulum and becomes an inorganic ion
- the inorganic ca binds to troponin c on the myofilament
- the molecule becomes SERCa2+ phospholamban
which has faster Ca2+ accumulation, adult cells or SC?
adult cells
what needs to be produced in order for the ca2+ to be transported?
production of ATP form mitochondrion form lactate, fat, glucose
what does a cardiac mri show?
structure and function of the heart
how does a cardiac mri work? (three things)
- using 31P to calculate PCr/ ATP ratios
- high resolution
- non invasive MR tagging
what does MR tagging show within a cardiac mri? (3 things)
- left ventricular mass
- blood pool volume
- ejection fraction
how do you calculate cardiac output?
CO= stroke volume x HR
How do you calculate ejection fraction?
EJ = (stroke vol/ end diastolic vol) x 100
how do you work out stroke volume?
difference between end-diastolic and end-systolic volume
at what time is the lowest blood pool volume?
400ms
what happens with CO with age?
it decreases
what happens to systolic bp with age ?
it increases
what happens to systolic bp with age ?
it increases
what happens to diastolic bp with age?
it decreases
what happens to the heart during heart failure
there is a reduction in the hearts ability to relax and contract
how many people in the UK have HF?
900,000
what percentage does HF relate to A/E admissions in the UK?
5%
what expenditure does HF contribute to?
2%
what are 4 risk factors for HF - reduced ejection fraction?
MI, alcohol, chemo, hypertension
how fast do symptoms of HF- rEF occur?
fast
what 3 things are risk factors for HF- pEF?
- hypertension
- diabetes
- obesity
how fast do symptoms of HF- pEF present?
gradual onset
what do pEF and rEF have in common?
similar symptoms which leads to terminal decline and death
in rEF, what occurs within neurohormonal activation?
- activation of sympathetic NS
- initial maintenance of arterial bp due to fall in CO
- leads to water retention, progressive LV re-modelling
what is the function of renin- angiotensin- aldosterone system?
regulate blood pressure and fluids
what do ACEi do and what does it treat?
an inhibitor of renin to angiotensin II
treats hypertension and reduces HF mortality
what is the function of ARB?
prevents angiotensin II binding to its receptor
what do beta blockers do?
produce negative chronotropic and inotropic effects
what are chronotropic effects?
the increase of heart rate
what are inotropic effects?
the increase of contractability
what are the adverse affects of using drugs to control RAAS system?
mainly only reduce bp - not actually treating HF
highly complex - patient needs to be in full understanding
electrolytes and renal function needs close monitoring
specialist care required - mdt
what causes HF- pEF?
rise in hypertension
atrial fibrillation
diabetes
ischaemic heart disease
what is the most common type of HF?
left ventricular systolic dsyfunction
what is the basis of HF- REF?
unpaired contractions
what is the basis of HF- PEF?
muscle thickening
what 3 drug classes are the most optimal way to treat HF?
- ACE inhib
- beta blockers
- mineralocorticoid antagonists eg aldosterone
name three ACE inhib
- ramipril
- lisonopril
- enalpril
what are the side effects of using ACE inhib?
dry cough, hyperkalaemia, renal impairments