AEMCA ALSPCS PHARM Flashcards
what is the mechanism of action of Acetaminophen?
it inhibits prostaglandin synthesis in the CNS and activates cannabinoid and serotonin receptors resulting in analgesic and antipyretic properties without Neurological side effects
what is the mechanism of action for ASA?
- it inhibits that action of COX1 blocking the formation of TXA2 which is a vaso constrictor and causes the aggregation of platelets
why is ASA contraindicated for pts who are asthmatic with no prior use?
it can induce bronchoconstriction due to the inhibition of the COX enzymes in the respiratory system which play a role in maintaining bronchodilation.
what is the mechanism of action for Dexamethasone?
it binds to glucocorticoid receptors inhibiting pro-inflamatory signals and promotes anti-inflammatory signals
what is the mechanism of action for dimenhyrinate?
it antagonizes anti-muscarinic cholinergic receptors and H1 receptors
it suppresses N/V only associated with chemoreceptor trigger zone
what is the mechanism of diphenhydramine?
- antagonizes central and peripheral H1 receptors reducing histamine release
what is the mechanism of action to the alpha 1 and 2 receptors with regards to Epi
a1 - systemic vasoconstriction increasing preload
a2 - inhibits insulin release
what is the mechanism of action to the Beta 1 and 2 receptors with regards to Epi?
b1- positive intropic, chronotropic, and dromotropic effects on the heart increasing CO
b2 - bronchodilation
what is the mechanism of action for ibuprofen?
- decreased prostiglandins by inhibiting cyclooxygenase (COX1 and COX2)
why is ibuprophen contraindicated in pregnant patients?
it can close the ductus arteriosus in utero in the third trimester
what is the mechanism of action for odansetron
blocks serotonin at the 5-HT3 receptor found throughout the CNS and PNS which has effect in blocking N/V due to the stimulation of the vagus nerve
