AEDs

Question 1

What is main target of AEDs?
1.
2.
3.

Answer 1

1. interfere ion ch.
2. increase GABAergic system
3. Glutamatergic system

Question 2

What drug is only used in status epilepticus?

Answer 2

Diazepam(benzodiazepines group)

Question 3

What drug have bradyarrhythmias,hypotension,cardiac arrest side effect?

Answer 3

Phenytoin(PHT)

Question 4

What drug is associated with gene HLA-B*1502?

Answer 4

Carbamazipine(CBZ)

Question 5

Which AEDs is a broad spectrum?

Answer 5

Sodium valproate(VPA)

Question 6

What drug is used in neuropathic pain?

And what is specific with trigerminal neuralgia?

Answer 6

Gabapentin and Cabamazepine(specific with trigerminal neuralgia)

Question 7

Which AEDs is useful in absence seizure?

Answer 7

Sodium valproate,Ethosuximide

Question 8

Which AEDs is a first line for complex partial seizure?

Answer 8

Carbamazepine

Question 9

What is an AED cause gum hyperplasia?

Answer 9

Phenytoin

Question 10

What is an AED cause closed angle glaucoma?

Answer 10

Topiramate

Question 11

Which AEDs is an enzyme inhibitor?

Answer 11

Sodium valproate

Question 12

What AEDs can help prevent migraines?

Answer 12

Sodium valproate

Question 13

Which AEDs have an autoinnduction?

Answer 13

Carbamazepine

Question 14

Which AEDs have zero order kinetics?

Answer 14

Phenytoin

Question 15

Which AEDs should avoid in pregnancy?

Answer 15

Phenytoin->fetal hydantion syndrome
and 
Valproate->neural tube defect
(AEDs: 2.5-7 fold increased rate of 
malformations at birth)

Question 16

Which AEDs have megaloblastic anemia

Side effect?

Answer 16

Phenytoin,Valproate,Phenobarbital(ต้องให้folate supplement)

Question 17

Which AEDs have metabolic acidosis side effect?

Answer 17

Topiramate

Question 18

What is an AED cause SIADH

Answer 18

Carbamazepine