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*******Neuro clerkship > AEDS > Flashcards

AEDS Flashcards

1
Q

phenytoin

A

(dilantin)
Na+ channel
partial, generalized
SE: gingival hyperplasia, coarse facial features

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2
Q

carbamezapine

A

(tegretol)
Na+ channel
partial, generalized
SE: SIADH, agranulocytosis

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3
Q

valproic acid

A

(depakote)
Na+ channel, GABA receptor
partial, general, absence
SE: GI symp, tremor, weight gain, hair loss, hepatotoxicity, thrombocytopenia

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4
Q

phenobarbital

A

GABA receptor
partial, generalized
SE: sedation

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5
Q

ethosuximide

A

(zarontin)
T type Ca channel
absence
SE: GI upset

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6
Q

lamotrigine

A

(lamictal)
Na+ channel, glutamate receptor,
partial, generalized
SE: Rash, Stevens-Johnson

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7
Q

gabapentin

A

(neurontin)
unknown
partial
SE: sedation, ataxia

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8
Q

topiramate

A

(topamax)
unknown
partial, generalized
SE: word finding difficulty, weight loss, renal stones

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9
Q

Tiagabine

A

(gabitril)
GABA reuptake
partial
SE: sedation

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10
Q

What AED can cause SJS?

A

lamotrigine

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11
Q

Which AED causes weight gain?

A

valproic acid

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12
Q

Which AED causes weight loss?

A

topiramate

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13
Q

Which AEDs are NOT used for generalized seizures?

A

ethosuximide (absence)
gabapentin (partial)
tiagabine (partial)

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14
Q

Which AEDs act on Na+ channels?

A

phenytoin, carbamezapine, valproic acid (+ GABA), lamotrigine (+ glutamate)

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15
Q

Which AEDs have unknown mech?

A

gabapentin, topiramate

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16
Q

Which AEDs act on GABA receptors?

A

valproic acid (& Na+)
phenobarbital
tiagabine (reuptake)

17
Q

Which AED also acts on glutamate receptors?

A

lamotrigine

18
Q

Which acts on T type calcium channels?

A

ethosuximide

19
Q

Which can cause word finding difficulty?

A

topiramate

also weight loss, renal stones

20
Q

Which can cause gingival hyperplasia?

A

phenytoin

+ coarse facial features

21
Q

Which is known for being hepatotoxic?

A

valproic acid

also weight gain, hair loss, thrombocytopenic, GI symp

22
Q

Which is known for agranulocytosis?

A

carbamezapine (also SIADH)

23
Q

Which is assoc w/ neural tube defects?

A

valproic acid

*******Neuro clerkship (8 decks)

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