AEDS Flashcards
phenytoin
(dilantin)
Na+ channel
partial, generalized
SE: gingival hyperplasia, coarse facial features
carbamezapine
(tegretol)
Na+ channel
partial, generalized
SE: SIADH, agranulocytosis
valproic acid
(depakote)
Na+ channel, GABA receptor
partial, general, absence
SE: GI symp, tremor, weight gain, hair loss, hepatotoxicity, thrombocytopenia
phenobarbital
GABA receptor
partial, generalized
SE: sedation
ethosuximide
(zarontin)
T type Ca channel
absence
SE: GI upset
lamotrigine
(lamictal)
Na+ channel, glutamate receptor,
partial, generalized
SE: Rash, Stevens-Johnson
gabapentin
(neurontin)
unknown
partial
SE: sedation, ataxia
topiramate
(topamax)
unknown
partial, generalized
SE: word finding difficulty, weight loss, renal stones
Tiagabine
(gabitril)
GABA reuptake
partial
SE: sedation
What AED can cause SJS?
lamotrigine
Which AED causes weight gain?
valproic acid
Which AED causes weight loss?
topiramate
Which AEDs are NOT used for generalized seizures?
ethosuximide (absence)
gabapentin (partial)
tiagabine (partial)
Which AEDs act on Na+ channels?
phenytoin, carbamezapine, valproic acid (+ GABA), lamotrigine (+ glutamate)
Which AEDs have unknown mech?
gabapentin, topiramate
Which AEDs act on GABA receptors?
valproic acid (& Na+)
phenobarbital
tiagabine (reuptake)
Which AED also acts on glutamate receptors?
lamotrigine
Which acts on T type calcium channels?
ethosuximide
Which can cause word finding difficulty?
topiramate
also weight loss, renal stones
Which can cause gingival hyperplasia?
phenytoin
+ coarse facial features
Which is known for being hepatotoxic?
valproic acid
also weight gain, hair loss, thrombocytopenic, GI symp
Which is known for agranulocytosis?
carbamezapine (also SIADH)
Which is assoc w/ neural tube defects?
valproic acid
