Adverse Drug Reactions

Question 1

Red Man’s Syndrome with which antibiotic?

Answer 1

Vancomycin

Question 2

Describe clinical features of Red Man’s syndrome

Answer 2

Fever, Chills, Phlebitis at site of infusion

Question 3

How is Red Man’s syndrome prevented?

Answer 3

By administering Vancomycin as a dilute solution slowly over at least 60mins, as Red Man’s syndrome is due to too rapid administration of Vancomycin.

Question 4

Which medication is the most well know cause of Stevens-Johnson’s syndrome?

Answer 4

Iamotrigine

Question 5

What is the mild/moderate ADR for sulfonamide?

Answer 5

GI disturbances such as nausea and bloating

Question 6

If there is non-urticarial rash with penicillin, without angio-oedema or anaphylaxis, which beta-lactams can still be given with caution if needed?

Under which condition will ALL beta-lactams be contraindicated?

Answer 6

Cephalosporins, Carbapenems, and Monobactams could still be used with caution if appropriate.

However, all beta-lactams will be contraindicated if there is an anaphylatic reaction, angio-oedema or eruption of urticarial rash, after taking Penicillin.