Adverse Drug Reactions Flashcards
What is the major side effect of zidovudine?
Macrocytic anemia
What are the 2 major side effects of didanosine and stavudine?
Neuropathy and pancreatitis
What are the common side effects of Abacavir?
Hypersensitivity and Stevens-Johnson
What are the common side effects of protease inhibitors?
Hyperlipidemia, hyperglycemia
What is the most common side effects of indinavir?
Nephrolithiasis
What is the most common side effect of tenofovir?
Renal insufficiency
What are the common side effects of statins?
Elevated LFTs and myositis
What are the side effects of niacin?
Elevation in glucose and uric acid level, pruritis
What are the side effects of fibric acid derivatives?
Increased risk of myositis if combined with statins
What are the common side effects of cholestyramine
Flatus and abdominal cramping
What are the adverse effects of calcium channel blockers
Edema, constipation and heart block
Who can you not use metformin in? Why?
People with renal dysfunction, it causes metabolic acidosis
When can you not use thiazoladinediones (glitazones)
CHF patients, causes fluid overload
What are the most common adverse effects of inhaled steroids?
Dysphonia and oral candidiasis
What are the adverse effects of theophylline?
Cardio and neurotoxicity
What are the adverse effects of Zafirleukast?
Hepatotoxicity and Churg Strauss
What is the main SE of imipenem
Seizures
What is the toxicity of rifampin?
Red coloration
What is the SE of isoniazid?
Peripheral neuotoxitiy
How do you prevent the side effect of isoniazid?
give pyridoxine with it
What is the toxicity of pyrazinamide?
Hyperuricemia
What is the SE of ethambutol?
Optic neuritis/color vision disruption
What gout treatments can you not use with renal insufficiency?
Probenecid, NSAIDs and slfinpyrazone
What are the side effects of cochicine?
Diarrhea and bone marrow supression
What are the side effects of methotrexate?
Liver toxicity, bone marrow suppression and pulmonary toxicity
What is the major side effect of hydroxychloroquine?
Retinal toxicity (follow with dilated eye exams)
What are the common side effects of sulfasalazine?
Bone marrow toxicity, hemolysis in G6PD deficiency and rash
What is the common side effect of doxorubicin?
Cardiomyopathy
What is the common side effect of vincristine?
Neuropathy
What is the common side effect of Bleomycin?
Lung fibrosis
What is the common side effect of cyclophophamide?
Hemorrhagic cystitis (give Mesna to prevent)
What is the common side effect of cisplatin?
renal and ototoxicity
What are the most common side effects of interferon?
Arthragias, thrombocytopenia, depression and leukopenia
What is the common side effect of ribavirin?
anemia
What is the common side effect of adefovir?
Renal dysfunction
