Adverse Drug Reactions

Question 1

List 4 drugs with a narrow therapeutic index

Answer 1

Digoxin

Warfarin

Phenytoin

Theophylline

Question 2

List drugs that commonly INDUCE Cytochrome P450 - PC BRAS

Answer 2

Phenytoin

Carbamazepine

Barbiturates

Rifampicin

Alcohol (chronic excess)

Sulphonylureas

Question 3

List drugs that commonly INHIBIT Cytochrome P450 - AO DEVICES

Answer 3

Allopurinol

Omeprazole

Disulfiram

Erythromycin

Valoprate

Isoniazid

Ciprofloxacin

Ethanal (acute intoxification

Sulphonamides

Question 4

Beta blockers + Verapamil/Diltiazem can cause what?

Answer 4

Heart block

Question 5

Metronidazole + Alcohol can cause what?

Answer 5

Profuse vomiting

Question 6

Metronidazole + Disulfiram can cause what?

Answer 6

Sweating, Flushing, Nausea and Vomiting

Question 7

NSAIDs + SSRIs can cause what?

Answer 7

GI bleeding

Question 8

Metformin can cause what adverse effect?

Answer 8

Lactic acidosis

Question 9

MAOi and Cheese (tyramine) can cause what?

Answer 9

Hypertensive crisis

Question 10

Warfarin + Alcohol can cause what?

Answer 10

Chronic decreases effects of Warfarin

Acute increases effects of Warfarin

Question 11

Warfarin + Cranberry/Grapefruit/Pomegranite juice can cause what?

Answer 11

Increases effects of warfarin

Question 12

What drug is used to reverse the effects of Heparin/LMWH?

Answer 12

Protamine Sulfate

Question 13

What drug is used to reverse the effects of Dabigatran?

Answer 13

Idraucizumab (MAB)