adverse drug reactions Flashcards
1
Q
what is predictable adr
A
adr related to pharmacological actions of drugs
2
Q
what is unpredictable adr
A
rare effects not detectable at the time of clinical trial, will only surface after more widespread use
3
Q
what are the characteristics of an immunogenic response
A
prior exposure
delayed in onset
can occur with subsequent low doses
reactions conform to immunogenic response ( type 1-4 hypersensitivity)
4
Q
What does valproate do to diazepam
A
displaces diazepam leading to increase free drug concentration
