Adult Psychiatry 2.1 Flashcards
What types of ED are recognised in ICD 10?
Anorexia
Bulimia
EDNOS
What does Binge eating disorder fall under in ICD 10?
EDNOS
How many patients with bulimia have a hx of anorexia?
1/4 - 1/3
Which criteria for anorexia has been eliminated in DSM V?
Amenorrhoea
Diagnostic criterion for bulimia for DSM V?
Once-weekly frequency of binge eating and inappropriate compensatory behaviour
Which types of patients with ED engage with treatment better and why?
Bulimia, due to feelings of loss of control
Onset of anorexia?
Adolescence
Onset of bulimia?
Young adults
Class distribution of bulimia?
Even distribution
Prevalence of anorexia in teenage girls
0.5-1%
Prevalence of bulimia in 16-35?
1-2%
Prevalence of anorexia in females per year
19/100,000
Prevalence of bulimia in females per year
29/100,000
Comorbid psychiatric disorders in patients with anorexia?
65% have depression
34% have social phobia
26% have OCD
What personality traits are associated with bulimia?
Substance use in families
What personality traits are associated with anorexia?
Obsessional and perfectionist in families
MZ vs DZ rates of anorexia
55% MZ
5% DZ
MZ vs DZ rates of bulimia
33% MZ
30% DZ
Heritablility of ED?
Significant heritability for anorexia
Not for bulimia
Risk factors for ED
Female, adolescence and early adulthood
Western cultural adaptation
FHx of ED, depression, substance misuse (EtOH and obesity for bulimia)
Adverse parenting
Occupational and recreational pressure to be slim
Low self-esteem, perfectionism (in anorexia)
Hx of obesity (bulimia)
Early menarche (bulimia)
What type of parenting is related to ED?
Low contact, high expectations, parental discord
Childhood abuse
Critical comments re eating and weight
What characterises binge eating disorder?
Recurrent episodes of binge eating in absence of extreme weight control behaviour.
Background of tendency to overeat.
How many patients seeking treatment for binge eating disorder are obese?
5-10%
Typical characteristics of patients with Binge eating disorder?
Present in 40s
Male (25% male)
High degree of spontaneous remission
Stress associated overeating
Treatment for binge eating disorder?
Self-help
Behavioural weight loss programmes
CBT/IPT
Physical sx of ED
Increased sensitivity to cold
GI sx - constipation, bloating
Dizziness and syncope
Amenorrhoea, low sexual appetite, infertility
Poor sleep with early morning wakening
Physical signs of ED
Emaciation, stunted growth and failure of breast development if pre-pubertal
Lanugo on back, forearms and side of face
Russels sign
Swelling of parotid and submandibular glands in bulimia
Perimylolysis
Hypothermia
Bradycardia, orthostatic hypotension, cardiac arrhythmias
Dependent oedema
Week proximal muscles
When does orange discolouration of skin occur in ED?
In hypercarotenaemia
What is Perimylolysis?
Erosion of inner surface of teeth
Endocrinel abnormalities in ED
Low LH, FSH and oestradiol
Low T3, T4, Normal TSH
Increase in plasma cortisol
Raised GH
Hypoglycaemia
Low leptim
Cardiovascular abnormalities in ED
ECG abnormalities; conduction defects, prolonged QT
Myopathy and fatal cardiomypathy can be caused by ipecac (emetic substance) which contains emetine (an alkaloid)
GI signs of ED
Delayed gastric emptying
Decreased colonic motility secondary to laxative misuse
Acute gastric dilatation secondary to binge eating or excessive re-feeding
Haematological abnormalities in ED
Moderate normocytic normochomric anaemia
Mild leucopenia with relative lymphocytosis
Thrombocytopenia
Metabolic abnormalities in ED
Hypercholesterolaemia
Raised seum carotene
Low phosphate (refreeding)
Dehydration
Metabolic abnormalities due to vomiting
Metabolic alkalosis
Hypokalaemia
Metabolic abnormalities due to laxativ misuse
Metabolic acidosis
Hyponatraemia
Hypokalaemia
Other abnormalities of ED
Osteopenia and osteoporosis; increased fracture risk
Enlarged cerebral ventricles and external CSF spaces (pseudo-atrophy)
Effects of ED on preganncy
Decreased fertility
More abortions
Higher rates of hyperemesis gravidarum, anaemia, impaired weight gain
Compromised intrauterine fetal growth
Premature delivery
Post-partum depression
Low birth weight, microcephaly, low APGAR
Hypoglycaemic neonate
In which ED is there food evidence of antidepressants?
Bulimia
In which ED does cognitive analytic therapy (CAT) not work?
Bulimia
In which ED is there good evidence for CBT?
Bulimia
In which ED is there no evidence for family-based therapy for adolescence?
Bulimia
In which ED is there no evidence for interpersonal psychotherapy?
Anorexia
Most effective treatment for bulimia?
CBT
How long is CBT for bulimia?
20 individual sessions voer 5 months
Recovery rate for bulimia with CBT
33-50% make full recovery
How do antidepressants help in bulimia?
Rapid decline in frequency of binge eating and purging
Improvement in moood
Problem with antidepressant therapy in bulimia?
Effect not sustained
Therapeutic goals for anorexia?
Engagement
Weight restoration
Psychological therapy - cognitive restructuring
If needed, use of compulsion
When does OP therapy for anorexia have best chance?
Illness present for <6 months
No bingeing or vomiting
Having parents who cooperate and are willing to participate in family therapy
Guidance re medications for anorexia?
Should never be used as primary treatment
What therapies should be considered for anorexia?
CBT/CAT
Interpersonal psychotherapy
Focal dynamic therapy
Family interventions focused on ED
What is helpful for adolescents with ED?
Family interventions that directly address the ED
First line treatment for bulimia
Self-help programmes and/or antidepressants
First line SSRI for bulimia
Fluoxetine 60mg OD
Therapy for buimia
Specifically adapted CBT; 16-20 sessions over 4-5 months
or Interpersonal psychotherapy but can take 8-12 months for results
Which psychiatric disorders are most frequently treated by psychiatrists?
PD
Prevalence of PD?
5-13%
Most prevalent PD in psychiatric settings
BPD
In which group of psychiatric inpatients is prevalence of PD high?
Those with drug and alcohol misuse
ED
Prevalence of PD in those with ED, alcohol or drug misuse
> 70%
Most common PD in prison?
Dissocial
Prevalence of any PD in prison?
78% for male on remand
64% for male sentenced
50% for females
Prevalence of PD in prisons
53% of male remand
49% of sentenced
31% of female prisoners
Prevalence of antisocial PD in UK
0.6%
Male vs female prevalence of PD in UK
Males have 5x prevalence compared to women.
Males 1%
Females 0.2%
Prevalence of PD and geographical areas?
Higher rates in urban areas