Adrenoceptor Antagonists: Drug - Notes

Question 1

Phenoxybenzamine

Answer 1

a1
IRREVERSIBLE COVALENT BOND
SE: PHT, reflex increase in HR

Question 2

Phentolamine

Answer 2

alpha antagonist
competitive
low use
SE: PHT reflex tachycardia

Question 3

Prazosin

Answer 3

a1
competitive
NO reflex tachycardia
SE: 1st Pass Effect, PHT, Nausea, Drowsiness

Question 4

Tamsulosin

Answer 4

a1
competitive
NO reflex tachycardia
SE: 1st Pass Effect, PHT, Nausea, Drowsiness

Question 5

Propranolol

Answer 5

Non-selective BB
LA Action
no ISA
CI: HF, Asthma, Diabetes, Insomnia, Cardiac Depression, Raynaud

Question 6

Pindolol

Answer 6

B antagonist
LA Action
no ISA
Angina commonly

Question 7

Timolol

Answer 7

B antagonist
NO LA action
Glaucoma commonly

Question 8

Metoprolol

Answer 8

b1 selective
LA action
NO ISA
SVT arrhythmia

Question 9

Atenolol

Answer 9

b1
NO LA
No ISA
Low lipid solubility
CI: Preg

Question 10

Nebivolol

Answer 10

b1 selective (less than 10 mg)
vasodilator
Nitrous Oxide
NO LA/ISA
Good Lipid Solubility

Question 11

Esmolol

Answer 11

b1 selective
No LA/ISA
Very Short Acting (10 Mins)

Question 12

Labetalol

Answer 12

B and A blocker
Some B agonist action
PHT

Question 13

Carvedilol

Answer 13

B and A blocker
PHT
Commonly HF