Adrenoceptor Agonists: Drug-Notes

Question 1

NE

Answer 1

a/b1,b3,(b2)

I: MAOI, TCA

Question 2

Epi

Answer 2

a/b1,b2,(b3)

I: MAOI, TCA

Question 3

Dopamine

Answer 3

a1/b1/D
Precursor to NE
I: MAOI

Question 4

Pramiprexole

Answer 4

D-agonists
Prami means some D3 selectivity
SE: Drowsiness

Question 5

Fenoldopam

Answer 5

D1 agonist
SE: Increase HR
SE: Increase Ocular Pressure
SE: Decrease K+

Question 6

Isoproterenol

Answer 6

beta agonist
Synthetic (not endogenous)
BP decrease/stay the same
Increase HR

Question 7

Phenylephrine

Answer 7

Not commonly used for hypotension

SE: CV = Reflex Bradycardia

Question 8

Methoxamine

Answer 8

Not commonly used for hypotension

SE: CV = Reflex Bradycardia

Question 9

Clonodine

Answer 9

a2
Decrease CNS Sympathetic outflow
Inhibit NE release
SE: Dry mouth, Sedation, Impotence

Question 10

alpha-methyl-dopa

Answer 10

Metabolized to a-methyl-NE (a2 agonist)

positive combs test

Question 11

Dexmedetomidine

Answer 11

a2 agonist

no respiratory depression

Question 12

Tizanidine

Answer 12

a2 agonist

Short acting

Question 13

Dobutamine

Answer 13

b1
IV infusion
Increase CO
Tolerance and Desensitization

Question 14

Albuterol

Answer 14

b2 selective
Oral = 1-2 hr onset/4-6 duration
Inhale= 5-10 mins/3-4 duration
SE: CV, less with inhale

Question 15

Terbutaline

Answer 15

b2 selective

not FDA approved for premature labor but is cheaper and longer lasting than Ritodrine

Question 16

Salmeterol

Answer 16

b2 selective
12 hr duration
Increase risk of death