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Unit 2 Pharm Drugs > Adrenergic Receptor Antagonists > Flashcards

Adrenergic Receptor Antagonists Flashcards

1
Q

Phentolamine (Regitine) MOA

A

Alpha 1 and 2 receptor antagonist

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2
Q

Phentolamine (Regitine) Therapeutics

A
  1. Pheochromocytoma
  2. Raynaud’s
  3. Frostbite
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3
Q

Phentolamine (Regitine) SE

A
  1. Postural hypotension

2. Inhibit ejaculation

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4
Q

Prazosin (Minipress) MOA

A

Alpha 1 receptor antagonist

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5
Q

Prazosin (Minipress) Therapeutics

A
  1. Primary HTN

2. BPH

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6
Q

Prazosin (Minipress) SE

A
  1. Postural hypotension (usually first dose)
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7
Q

Terazosin (Hytrin) MOA

A

Alpha 1 antagonist

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8
Q

Terazosin (Hytrin) Therapeutics

A
  1. Primary HTN

2. BPH

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9
Q

Terazosin (Hytrin) SE

A
  1. Postural hypotension (usualy first dose)
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10
Q

Alpha receptor antagonist MOA

A

Reduces sympathetics tone of blood vessels leading to decrease peripheral resistance: decreases bp and reduces smooth muscle tone in bladder, neck, and prostate

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11
Q

Common suffix of alpha receptor antagonists

A

-zosin

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12
Q

Clinical indications of Alpha blockers

A
  1. HTN

2. BPH

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13
Q

First dose effect of alpha blockers

A

First dose may produce an exaggerated hypotensive response that results in syncope. May be minimized by slowly titrating dose or give dose at bedtime

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14
Q

Common suffix of beta receptor antagonists

A

-lol

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15
Q

Beta receptor antagonists MOA

A

Competitive inhibition

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16
Q

Clinical indications for use of beta blockers

A
  1. HTN
  2. Arrhythmias
  3. Angina
  4. Glaucoma
  5. Migraine prophylaxis
  6. Stage fright
  7. Chronic CHF (Use only 2nd or 3rd generation)
17
Q

Major SE of Beta blockers

A
  1. Cardiac depression

2. Bronchoconstriction

18
Q

Propanolol (Inderal) MOA

A

Beta 1 and 2 receptor antagonist. (Nonselective, first generation)

19
Q

Propanolol (Inderal) Therapeutics

A
  1. Angina
  2. HTN
  3. Arrhythmias
20
Q

Propanolol (Inderal) SE

A
  1. Bradycardia
  2. Bronchoconstriction
  3. Sexual dysfunction
21
Q

Metoprolol (Lopressor) MOA

A

Beta 1 receptor antagonist. Second generation antagonist

22
Q

Metoprolol (Lopressor) Therapeutics

A
  1. HTN
  2. Angina
  3. Arrhythmias
  4. CHF
23
Q

Metoprolol (Lopressor) SE

A
  1. Bradycardia
  2. Bronchoconstriction
  3. Sexual dysfunction
24
Q

Atenolol (Tenomin) MOA

A

Beta 1 receptor antagonist. Second generation

25
Q

Atenolol (Tenomin) Therapeutics

A
  1. HTN
  2. Angina
  3. Arrhythmias
  4. CHF
26
Q

Atenolol (Tenomin) SE

A
  1. Bradycardia
  2. Bronchoconstriction
  3. Sexual dysfunction
27
Q

Carvedilol (Coreg) MOA

A

Non-selective Beta 1 and Beta 2 receptor antagonists with alpha 1 antagonism. Third generation

28
Q

Carvedilol (Coreg) Therapeutics

A
  1. CHF

2. HTN

29
Q

Carvedilol (Coreg) SE

A
  1. Bradycardia

2. Fatigue

30
Q

“Workhorse” by which all other beta blockers are compared

A

Propanolol

Unit 2 Pharm Drugs (9 decks)

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