Adrenergic Receptor Antagonists Flashcards
Phentolamine (Regitine) MOA
Alpha 1 and 2 receptor antagonist
Phentolamine (Regitine) Therapeutics
- Pheochromocytoma
- Raynaud’s
- Frostbite
Phentolamine (Regitine) SE
- Postural hypotension
2. Inhibit ejaculation
Prazosin (Minipress) MOA
Alpha 1 receptor antagonist
Prazosin (Minipress) Therapeutics
- Primary HTN
2. BPH
Prazosin (Minipress) SE
- Postural hypotension (usually first dose)
Terazosin (Hytrin) MOA
Alpha 1 antagonist
Terazosin (Hytrin) Therapeutics
- Primary HTN
2. BPH
Terazosin (Hytrin) SE
- Postural hypotension (usualy first dose)
Alpha receptor antagonist MOA
Reduces sympathetics tone of blood vessels leading to decrease peripheral resistance: decreases bp and reduces smooth muscle tone in bladder, neck, and prostate
Common suffix of alpha receptor antagonists
-zosin
Clinical indications of Alpha blockers
- HTN
2. BPH
First dose effect of alpha blockers
First dose may produce an exaggerated hypotensive response that results in syncope. May be minimized by slowly titrating dose or give dose at bedtime
Common suffix of beta receptor antagonists
-lol
Beta receptor antagonists MOA
Competitive inhibition